The Prevalence of CYP2C8, 2C9, 2J2, and Soluble Epoxide Hydrolase Polymorphisms in African Americans With Hypertension

Dreisbach, Albert W.; Japa, Shanker; Sigel, A; Parenti, M; Hess, Aaron; Srinouanprachanh, Sengkeo; Rettie, Allan E.; KIM, H; Farin, Frederico M.; Hamm, L. Lee

doi:10.1016/j.amjhyper.2005.04.019

Cited by 90 publications

(65 citation statements)

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“…In a Chinese population, plasma levels of 14,15-dihydroxyeicosatrienoic acid were found significantly lower in CYP2J2*7 T allele carriers than the in GG subjects (table 1) [67]. In a case-control study in African American, several SNPs in CYP genes, including the CYP2J2*7, were studied and no association was found with hypertension [57].…”

Section: Cyp2j2 Hypertension and Cardiovascular Diseasesmentioning

confidence: 99%

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Fava

Ricci

Melander

et al. 2012

Prostaglandins & Other Lipid Mediators

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Section: Cyp2j2 Hypertension and Cardiovascular Diseasesmentioning

confidence: 99%

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Fava

Ricci

Melander

et al. 2012

Prostaglandins & Other Lipid Mediators

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“…[19][20][21][22] This is contradicting with the present study and the study done in African American population. 4 This probably may be due to differences in ethnicity, 12 which is an important factor attributed to clinical outcomes. Pharmacogentic variations in genes encoding CYP enzymes are increasingly important as it elucidates interand intra-ethnic differences owing to the therapeutic response, adverse events, prognosis, and disease susceptibility.…”

Section: Resultsmentioning

confidence: 99%

“…This is in accordance with previous studies. 4,19 However, similar studies in larger and different populations must be carried out to conclude the role of CYP genes in association with hypertension. …”

Section: Resultsmentioning

confidence: 99%

“…3 The epoxygenases of cytochrome CYP2J2 and CYP2C subfamilies catalyze oxidative metabolism of arachidonic acid into metabolites, which may have an infl uential role in hypertension. 4,5 Endothelial CYP enzymes are shown to play a prime role in regulation of blood pressure by acting as endothelium derived hyperpolarizing factor (EDHF) synthase. 5 The metabolites of arachidonic acid such as epoxyeicosatrienoic acid (EETs) and 20 hydroxyeicosatetraenoic acid are referred as EDHF, which also contributes to endothelium dependent vasodilation in addition to NO and prostacyclins (prostaglandin 12).…”

Section: Introductionmentioning

confidence: 99%

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Cytochrome P450 genetic variants and hypertension risk in South Indian population

Kumar¹,

Kumar²,

Umamaheswaran³

et al. 2014

J Young Pharm.

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Hypertension is a result of interaction between complex environmental and genetic factors. The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smooth muscle relaxation. Aim: The study is aimed to analyze the association of CYP2C8, CYP2C9, and CYP2J2 gene polymorphisms with the risk of hypertension in the South Indian population. Methods and Results: The case-control study consisted of 279 hypertensive patients and 321 healthy controls aged ranges between 30 and 60 years. The deoxyribonucleic acid was extracted using standard phenol-chloroform method. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. Multiple-logistic regression analysis was used to analyze the association between polymorphisms and the risk of hypertension. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 with hypertension. Conclusion: Our results suggest that CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 are not associated with hypertension in South Indian population.

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“…By contrast, a decreased risk of EH was reported by Lorraine M. King in Caucasian males carrying CYP2J2 variant alleles (rs890293) [12]. There was a study suggesting no significant association between the polymorphism of CYP2J2 (rs890293) and EH [17]. Based on the above study background, we aimed to assess the association between the polymorphism of CYP2J2 and EH in a Han and Uygur Population of China.…”

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphism of the CYP2J2 Gene is Associated with Essential Hypertension in Uygur Population in China

Amjad¹

2014

Biochem Anal Biochem

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Background: Human Cytochrome P450 2J2 (CYP2J2) is the major arachidonic acid epoxygenase, which can metabolizes arachidonic acid (AA) to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. Recently, many evidence from models and human studies suggests that variability of CYP2J2 gene plays a mechanistic role in the development of hypertension. The aim of the present study was to assess the association between the human CYP2J2 gene polymorphism and Essential Hypertension (EH) in a Han and Uygur population in China. Methods:We used two independent case-control studies: a Han population (302 EH patients and 300 control subjects) and a Uygur population (567 EH patients and 215 control subjects). All EH patients and controls were genotyped for the same three single nucleotide polymorphisms (SNPs) (rs890293, rs11572223 and rs2280275) of CYP2J2 gene by a Real-time PCR instrument. Results:In the Uygur population, the distribution of SNP3 (rs2280275) genotypes, alleles and the dominant model (CC vs CT + TT) showed a significant difference between EH and control participants (for genotype: P=0.007; for allele: P=0.001; for dominant model: P=0.002). The significant difference in dominant model was retained after adjustment for covariates (OR: 3.500, 95% confidence interval [CI]: 1.680-7.300, P=0.001). However, all the above differences were not shown in the Han population. Conclusions:The CC genotype of rs2280275 in CYP2J2 gene could be a risk genetic marker of EH and T allele may be a protective genetic marker of EH in Uygur population in China.

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The Prevalence of CYP2C8, 2C9, 2J2, and Soluble Epoxide Hydrolase Polymorphisms in African Americans With Hypertension

Abstract: These results suggest that these epoxygenase-related SNP are not associated with increased risk of hypertension in the African American population. There was significant linkage disequilibrium between CYP2C83 and CYP2C92 alleles that was not associated with hypertension.

Cited by 90 publications

References 27 publications

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Cytochrome P450 genetic variants and hypertension risk in South Indian population

Single Nucleotide Polymorphism of the CYP2J2 Gene is Associated with Essential Hypertension in Uygur Population in China

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The Prevalence of CYP2C8, 2C9, 2J2, and Soluble Epoxide Hydrolase Polymorphisms in African Americans With Hypertension

Abstract: These results suggest that these epoxygenase-related SNP are not associated with increased risk of hypertension in the African American population. There was significant linkage disequilibrium between CYP2C8*3 and CYP2C9*2 alleles that was not associated with hypertension.

Cited by 90 publications

References 27 publications

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Cytochrome P450 genetic variants and hypertension risk in South Indian population

Single Nucleotide Polymorphism of the CYP2J2 Gene is Associated with Essential Hypertension in Uygur Population in China

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Abstract: These results suggest that these epoxygenase-related SNP are not associated with increased risk of hypertension in the African American population. There was significant linkage disequilibrium between CYP2C83 and CYP2C92 alleles that was not associated with hypertension.