The prevalence of constipation and its relation to sweet taste preference among patients receiving methadone maintenance treatment

Sason, Anat; Adelson, Miriam; Schreiber, Shaul; Peles, Einat

doi:10.1016/j.drugalcdep.2021.108836

Cited by 1 publication

(2 citation statements)

References 37 publications

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“…The responses are scored on a Likert scale ranging from 0 to 5. Higher score indicates increase of severity of the negative effects of the intervention in question on QOL (Sason et al, 2021).…”

Section: Patient Assessment Of Constipation -Quality Of Life (Pac-qol)mentioning

confidence: 99%

“…However, given their opioid nature, they may cause serious side effects that negatively affect the therapeutic process by inducing responses, potentially leading patients towards craving and not rehabilitation (Noble and Marie, 2019). Research evidence indicates that they act detrimentally on the cognitive level of the patients, they deteriorate constipation, and they cause serious sleep disturbances (Dunn et al, 2018;Pujol et al, 2018;Sason et al, 2021). Buprenorphine and methadone have also been associated with impairment of blood antioxidant defense probably through enhancement of the levels of reactive oxygen species (ROS), whereas they have been related to inflammation and boost of craving and drug-seeking behavior (Chen et al, 2012;Leventelis et al, 2019;Lu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Pomegranate juice consumption by patients under medication for addiction treatment as regulator of craving and blood redox status: The study protocol of a randomized control trial (the NUTRIDOPE study)

Leventelis

Tasoulis

Kouretas

et al. 2023

Preprint

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Background Buprenorphine and methadone are considered the “gold standard” medication for addiction treatment (MAT) for patients with opioid use disorders (OUDs). However, they may cause side effects promoting craving. Pomegranate is a natural substance that contains antioxidant polyphenolic compounds, which have been associated with craving reduction. Aim: The NUTRIDOPE (NUTRItion-driven Detoxification of OPioid addicted patiEnts) study aims to investigate the role of pomegranate juice consumption by opioid patients under buprenorphine and methadone on craving, as the primary outcome, and biopsychosocial parameters. Methods NUTRIDOPE is a randomized control trial with repeated measures. The participants, who will be patients with OUDs attending rehab programs in the Greek Organization Against Drugs, will be randomly divided into the experimental and the control groups and both groups will be further stratified into two subgroups, i.e., methadone and buprenorphine, according to the maintenance treatment program they attend. Pomegranate juice will be administered to the participants of the experimental group, whereas their counterparts in the control group will not consume any similar beverage. The administration regimen will be 250 ml, seven days/week, four months. Results Craving, as well as physiological (sleep, constipation, fatigue), psychosocial (depression, mood state, quality of life) and biochemical (i.e., blood redox status and inflammation) parameters will be evaluated. Conclusions NUTRIDOPE is a hypothesis-driven, evidence-based, multifactorial project that proposes a nutrition-based solution towards craving reduction for opioid patients under MAT, potentially assisting towards their successful rehab and societal reintegration. ClinicalTrials.gov Identifier: NCT05861544

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Section: Patient Assessment Of Constipation -Quality Of Life (Pac-qol)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pomegranate juice consumption by patients under medication for addiction treatment as regulator of craving and blood redox status: The study protocol of a randomized control trial (the NUTRIDOPE study)

Leventelis

Tasoulis

Kouretas

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

The prevalence of constipation and its relation to sweet taste preference among patients receiving methadone maintenance treatment

Cited by 1 publication

References 37 publications

Pomegranate juice consumption by patients under medication for addiction treatment as regulator of craving and blood redox status: The study protocol of a randomized control trial (the NUTRIDOPE study)

Pomegranate juice consumption by patients under medication for addiction treatment as regulator of craving and blood redox status: The study protocol of a randomized control trial (the NUTRIDOPE study)

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