The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review

Chan, Y.; Jayaprakasan, Kanna; Zamora, Javier; Thornton, Jim; Raine‐Fenning, Nick; Coomarasamy, Arri

doi:10.1093/humupd/dmr028

Cited by 596 publications

(413 citation statements)

References 111 publications

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“…Potentially relevant congenital Mullerian tract anomalies include unicornuate, didelphic, bicornuate, septate or arcuate uteri. The presence of a uterine septum was not only the most prevalent congenital defect, but also the only congenital defect to be more common in patients with primary RM, occurring in this group at more than double the rate of septal defects among the women in the general population [5,13,21,29,36,67].…”

Section: Anatomymentioning

confidence: 94%

Recurrent Miscarriage: A Review

Barrenetxea¹

2017

RMGO

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pregnancy events [2]. Clinical miscarriages may be subdivided into early clinical pregnancy losses (before gestational week 12) and late clinical pregnancy losses (gestational weeks 12 to 21). The term miscarriage is preferred rather than abortion both by patients and physicians, although "spontaneous abortion" is still used in scientific literature [3,4].For more than 30 years, controversy has existed on the number of miscarriages required to define RM and when diagnostic testing is warranted [5] EpidemiologyEarly pregnancy loss is perhaps the most common obstetric complication, occurring in over two-thirds of human conceptions. Approximately 15 -20% of all clinically recognized pregnancies will end in a miscarriage [4,9,10]. However, prospective cohort studies using sensitive and specific daily urinary hCG assays in women trying to conceive have demonstrated that only around one-third of conceptions progress to a live birth. Most of the losses occur before the clinical recognition of pregnancy as implantation failures. An estimated 30% of human conceptions are lost prior to implantation and a further 30% following implantation but before the missed menstrual period, that is in the third or fourth week of gestation. These are often termed preclinical losses [11].The risk of sporadic miscarriage between 6 and 12 weeks of gestation in women less than 35 years of age is 9% to 12%. The risk increases with age. In women older than 40 years of age, the sporadic miscarriage rate approaches 50%. Late losses between 12 and 22 weeks occur less frequently and constitute around 4% of pregnancy outcomes [4,9].Compared to sporadic miscarriage the prevalence of RM is considerably lower irrespective of whether biochemical losses are included or not. Approximately 1% of all women trying to conceive have recurrent miscarriage, defined as three previous miscarriages; when recurrent miscarriage is defined as two previous miscarriages, the proportion rises to 3% [12,13]. EtiologyMultiple potential etiologies for RM have been described (Table 1). As a consequence, several recommendations have been published regarding the evaluation and management of RM [3].The potential etiologies of RM can be divided into embryologically driven causes (mainly due to an abnormal embryonic karyotype) and maternally driven causes which affect the endometrium and/or placental development [14,15]. Thus, studies that focus on RM have Barrenetxea G, et al., J Reprod Med Gynecol Obstet 2017 AbstractHuman reproduction is characterized by its inefficiency. The loss of pregnancy at any stage can be a devastating experience and particular sensitivity is required in assessing and counseling couples with Recurrent Miscarriage (RM). Recurrent Miscarriage (RM) represents a clinical challenge for physicians not only because there are multiple possible etiologies, but also because the diagnostic testing is costly and time consuming. Despite several well-known etiologic factors, the cause of RM cannot be determined in almost 50% of cases. Multiple potential etiolo...

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Section: Anatomymentioning

confidence: 94%

Recurrent Miscarriage: A Review

Barrenetxea¹

2017

RMGO

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“…In a Finnish study conducted in 165 nulliparous women the mean width of the uterine cavity, measured by ultrasonography, was 24.4 mm, ranging from 13.8 to 35.0 mm. In 2/3 of these young women the transverse width was less than this distance [31]. Without the aid of ultrasonic measurements physicians may be routinely, unknowingly inserting devices of sizes approaching 32 mm in uteri much too small to accommodate them.…”

Section: How To Avoid Iud Malposition and Displacementmentioning

confidence: 96%

“…Bicornuate uteri are uncommon (0.4%) and 0.1% of cases present with a unicornuate uterus. The prevalence of uterus didelphys is approximately 0.3% in an unselected population [31,32].…”

Section: How To Avoid Iud Malposition and Displacementmentioning

confidence: 99%

Malposition and displacement of intrauterine devices–diagnosis, management and prevention

Wildemeersch¹,

Hasskamp²,

Goldstuck³

2016

Clin Obstet Gynecol Reprod Med

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“…Congenital uterine anomalies (CUA), a rather common benign condition with a prevalence of 4-7% [1], result from the abnormal formation, fusion or resorption of Mullerian ducts during fetal life [2]. Depending on the type and degree of anatomical alteration, CUA are associated with relatively serious complications affecting the reproductive life.…”

Section: Introductionmentioning

confidence: 99%

Early Diagnosis of Congenital Uterine Anomalies: Is the Three Dimensional Ultrasound Approach the Suitable Choice? 3D in Uterine Anomalies

Riganelli¹,

Savone²

2016

J Clin Case Rep

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Purposes: Congenital uterine anomalies (CUA) are benign conditions associated with relatively serious complications affecting the reproductive life. Due to their infrequency CUA are often misdiagnosed, exposing the patient to possible future complications. Case description:We report the cases of three women affected by an unknown CUA, which underwent three different diagnostic and surgical approaches. Conclusions:A correct and early diagnosis of CUA is mandatory to allow a correct clinical and therapeutic management. In our opinion we might avoid the use of MRI considered as the second line technique after 2D-US, keeping in mind that in CUA the diagnostic value of 3D-US has the same accuracy as MRI.

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The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review

Cited by 596 publications

References 111 publications

Recurrent Miscarriage: A Review

Recurrent Miscarriage: A Review

Malposition and displacement of intrauterine devices–diagnosis, management and prevention

Early Diagnosis of Congenital Uterine Anomalies: Is the Three Dimensional Ultrasound Approach the Suitable Choice? 3D in Uterine Anomalies

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