The prevalence of coeliac disease in patients fulfilling Rome III criteria for irritable bowel syndrome

Shalaby, Sayed; Sayed, Moataz M.; Ibrahim, Wesam A.; Abdelhakam, Sara M.; Rushdy, Marwa

doi:10.1016/j.ajg.2016.05.003

Cited by 5 publications

(9 citation statements)

References 24 publications

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“…It was found that IBS-M subtype was common among MUHAS staff and students (56.3%) largely affecting females (59.9%). Similar findings have been reported in studies in Pakistan, Japan and China (2,14,20). While in Iranian medical students IBS-C was the predominant subtype (81.6%) (21).In African studies findings were similar to Pakistan, Japan and China where IBS-M was predominant (19.6% and 60.7%) (15,17).…”

Section: Discussionsupporting

confidence: 80%

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Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

Gembe

2020

Preprint

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Background: Global prevalence of irritable bowel syndrome is high among medical students and health care professionals with significant morbidity. Similarly, the prevalence of celiac disease in irritable bowel syndrome is higher than the general population. These conditions impair quality of life and contribute to social-economic burden. In Tanzania, little is known about irritable bowel syndrome and celiac disease among medical students and health care professionals. Methods: A cross sectional study was conducted to MUHAS and Mloganzila Academic Medical Center (MAMC) staff and students who fulfilled the online shared Rome IV criteria of irritable bowel syndrome from August to November 2018. A structured questionnaire was used to collect socio-demographic data, anthropometric measurements and clinical manifestations. Blood samples for full blood picture, liver enzymes and Erythrocyte Sedimentation Rate were taken. Celiac disease was tested using anti-tissue transglutaminase antibody test. Qualitative and quantitative data were summarized using frequency distribution tables. Chi-square and fishers exact test were used to study comparison between groups. Logistic regression was used to study associations. Data was analyzed using SPSS version 20.0 and a P value of ≤0.05 was considered significant.Results: Out of 1,321 participants, 192 (14.5%) had irritable bowel syndrome in which 77 (40.1%) were males and 115 (59.9%) were females. Among the 192 participants with irritable bowel syndrome, 3 (1.6%) were positive for celiac disease, 2 (66.7%) were females and 1 (33.3%) was a male. Of the 3 patients with CD, 2 had elevated ALAT and 1 had anaemia. Age (AOR 2.53, 95% C.I 1.57-4.09), sex (AOR 1.67, 95% C.I 1.16-2.41), marital status (AOR 4.95 C.I 2.07-11.82), alcohol intake (AOR 2.47, 95% C.I 1.16-5.23), year of study (AOR 8.49, 95% C.I 5.71-12.64) and sleep duration (AOR 2.24, 95% C.I 1.23-4.06) were found to be independently associated with IBS. Conclusion: Prevalence of IBS and its associated factors in our study population was similar to findings from studies done elsewhere. Also, our study revealed a low prevalence of celiac disease among IBS participants.

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Section: Discussionsupporting

confidence: 80%

“…genetically predisposed persons (1). Irritable bowel syndrome is a functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits in the absence of a specific bowel pathology (2). CD shares several symptoms that are present in the Rome IV criterion used in the diagnosis of IBS (3).…”

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confidence: 99%

Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

Gembe

2020

Preprint

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“…Eight patients required constipation medication such as osmotic laxatives, despite strict adherence to the diet. testing for CD in some FGID patients (2,11,13,16,17). In the current study, biopsy-proven CD was detected in 3.25% of children with functional constipation, which is common in childhood, particularly among toddlers and school children.…”

Section: Resultsmentioning

confidence: 85%

“…The manifestation of CD has also changed over the years; instead of classical symptoms such as diarrhea, growth retardation, and abdominal distention, atypical symptoms such as chronic constipation may be the only signs of CD. Abdominal pain, constipation, and meteorism are very common complaints during admission in pediatric gastroenterology clinics and are generally accepted as functional gastrointestinal disease (FGID) if there is a lack of alarm symptoms such as abdominal distention, bilious vomiting, bloody stools in the absence of anal fissures, sacral dimple, perianal fistula, and abnormal position of anus; these symptoms are also shared by CD (10)(11)(12). Despite the definition of functional diseases, CD is not routinely excluded in patients with chronic constipation, and there is no general recommendation to routinely test them (13,14).…”

Section: Introductionmentioning

confidence: 99%

Is celiac disease misdiagnosed in children with functional constipation?

Akman¹,

Şahaloğlu²,

Bahceciler³

et al. 2018

Turk J Gastroenterol

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“…Its clinical manifestations are characterized by diarrhea and abdominal pain or discomfort in the absence of a demonstrable pathology. The diagnosis of D-IBS is based on symptom assessment and the Rome III Diagnostic Criteria[1,2]. According to an epidemiological study, D-IBS mainly affects young adults of 20-40 years old, and the quality of their lives is seriously affected[3].…”

Section: Introductionmentioning

confidence: 99%

Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl^- and HCO₃^- channel

Yang

Xiong

Zhang

et al. 2016

WJG

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AIMTo investigate the pharmacological effect of TongXie-YaoFang (TXYF) formula, a Chinese herbal formula, on Diarrhea-predominant irritable bowel syndrome (D-IBS) rats.METHODSIn a neonatal maternal separation plus restraint stress (NMS + RS) model of D-IBS, male Sprague Dawley rats were randomly divided into two groups (NMS + RS group and TXYF-formula group) with no handlings were used as controls (NH group). Starting from postnatal day 60, rats in TXYF-formula group were administered TXYF-formula (4.92 g/100 g bodyweight) orally twice a day for 14 consecutive days while NH group and NMS + RS group were given distilled water. Using short-circuit current technology, we observed 5-HT-induced changes of current across ion channels, such as cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, epithelial Na+ channel (ENaC), Ca2+-dependent Cl- channel (CACC), Na+-K+-2Cl- co-transporter (NKCC), and Na+-HCO3- co-transporter (NBC), in the colonic epithelium of three groups after exposure to drugs and specific blockers with a Power Lab System (AD Instruments International).RESULTSUnder basal conditions, the changes of short-circuit current (∆Isc, µA/cm2) induced by 5-HT were similar in NH group and TXYF-formula group, and both higher than NMS + RS group (70.86 µA/cm2 ± 12.32 µA/cm2, 67.67 µA/cm2 ± 11.68 µA/cm2 vs 38.8 µA/cm2 ± 7.25 µA/cm2, P < 0.01, respectively). When CACC was blocked by 4,4′-diisothiocyanato-stilbene-2,2′-disulfonic acid, 5-HT-induced ∆Isc was smaller in NMS + RS group than in NH group and TXYF-formula group, respectively (48.41 µA/cm2 ± 13.15 µA/cm2 vs 74.62 µA/cm2 ± 10.73 µA/cm2, 69.22 µA/cm2 ± 11.7 µA/cm2, P < 0.05, respectively). The similar result could be obtained when ENaC was blocked by Amiloride (44.69 µA/cm2 ± 12.58 µA/cm2 vs 62.05 µA/cm2 ± 11.26 µA/cm2, 62.11 µA/cm2 ± 12.01 µA/cm2, P < 0.05, respectively). However, when CFTR Cl- channel was blocked by 1,1-dimethyl piperidinium chloride (DPC), 5-HT-induced ∆Isc did not significantly differ in three groups (42.28 µA/cm2 ± 10.61 µA/cm2 vs 51.48 µA/cm2 ± 6.56 µA/cm2 vs 47.75 µA/cm2 ± 7.99 µA/cm2, P > 0.05, respectively). The similar results could also be obtained in three groups when NBC and NKCC were respectively blocked by their blockers.CONCLUSIONTXYF-formula can regulate the Cl- and HCO3- secretion of colonic mucosa via CFTR Cl- channel, Cl-/HCO3- exchanger, NBC and NKCC co-transporters.

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The prevalence of coeliac disease in patients fulfilling Rome III criteria for irritable bowel syndrome

Cited by 5 publications

References 24 publications

Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

Is celiac disease misdiagnosed in children with functional constipation?

Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl^- and HCO₃^- channel

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The prevalence of coeliac disease in patients fulfilling Rome III criteria for irritable bowel syndrome

Cited by 5 publications

References 24 publications

Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

Is celiac disease misdiagnosed in children with functional constipation?

Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl- and HCO3- channel

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Product

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Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl^- and HCO₃^- channel