The prevalence of chlamydia trachomatis among patients with acute conjunctivitis in kasr alainy ophthalmology clinic

Mowafy, Maha A.; Saad, Nagwa Eid Sobhy; El-Mofty, Hala Mohamed; Elanany, Mervat; Mohamed, Marwa

doi:10.11604/pamj.2014.17.151.3818

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…This group suggested that IgG levels to CPAF may serve as a biomarker for patients at risk of inflammatory trachoma. More recently Mowafy et al [ 129 ] utilised tear ELISA assays to detect IgG and IgM of patients with trachoma.…”

Section: Tear Fluid Analysis In Ocular Diseasementioning

confidence: 99%

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

2016

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In the field of predictive, preventive and personalised medicine, researchers are keen to identify novel and reliable ways to predict and diagnose disease, as well as to monitor patient response to therapeutic agents. In the last decade alone, the sensitivity of profiling technologies has undergone huge improvements in detection sensitivity, thus allowing quantification of minute samples, for example body fluids that were previously difficult to assay. As a consequence, there has been a huge increase in tear fluid investigation, predominantly in the field of ocular surface disease. As tears are a more accessible and less complex body fluid (than serum or plasma) and sampling is much less invasive, research is starting to focus on how disease processes affect the proteomic, lipidomic and metabolomic composition of the tear film. By determining compositional changes to tear profiles, crucial pathways in disease progression may be identified, allowing for more predictive and personalised therapy of the individual.This article will provide an overview of the various putative tear fluid biomarkers that have been identified to date, ranging from ocular surface disease and retinopathies to cancer and multiple sclerosis. Putative tear fluid biomarkers of ocular disorders, as well as the more recent field of systemic disease biomarkers, will be shown.

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Section: Tear Fluid Analysis In Ocular Diseasementioning

confidence: 99%

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

2016

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“…In this sense, we consider maternal or prenatal infections of C. trachomatis, which is a member of Chlamydiaceae family, and the chlamydial non-gonococcic urethritis factor, as non-excludable from schizophrenia aetiopathogenesis [88]. It is well known that C. trachomatis is associated with manifestations such as conjunctivitis [89], nasopharyngitis [90], pneumonia [91] and rarely myocarditis [92], encephalitis [93]. An American study conducted in 2001 assessed the contribution of maternal infections during pregnancy to schizophrenia (or the other psychoses) development in adulthood and reported that neonatal HSV-2 seropositivity increased risk.…”

Section: Coherencementioning

confidence: 99%

Assessment of Association between Schizophrenia and Chlamydiaceae Using Hill Criteria

Kocazeybek

Kalaycı²

2015

J Psychiatry

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Schizophrenia is a complex chronic neuropsychiatric disorder of the central nervous system with worldwide prevalence. The disease is thought to have multiple etiologies, including infections, genetic predisposition, and other environmental factors. There is increasing evidence pointing to a close association between chlamydial infections and schizophrenia. Here, we review the data available in the literature on the detection of bacterial species in the family Chlamydiaceae in schizophrenia and critically analyze the association and causal relationship between Chlamydiaceae and schizophrenia following the established criteria of Hill. This analysis demonstrates a probable causal relationship between Chlamydiaceae and schizophrenia. The identification of microbial agents associated with the etiopathogenesis of schizophrenia may provide new insight into the diagnosis, treatment and prevention of the disorder.

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Etiological characteristics of chlamydia trachoma conjunctivitis of Primary Boarding School students in the Qinghai Tibetan area

Wang

et al. 2016

Sci. China Life Sci.

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The aim of this study was to investigate the etiological characteristics of Chlamydia trachomatis conjunctivitis among resident students at primary schools in the Qinghai Tibetan area in order to understand the distribution of C. trachomatis and other pathogenic microorganisms, to detect the isolation rate of infectious pathogens, and to provide an evidence for further targeted efforts in the prevent of sporadic trachoma efforts. From two primary schools in Qinghai Province, ocular samples from 35 students who were clinically diagnosed as trachoma cases and 60 normal controls were obtained by swabbing their upper eyelids and lower conjunctival sacs. Samples were preserved at 4°C and airlifted to Beijing Tongren Hospital within 24 h. Real- time polymerase chain reaction (RT-PCR) was used to screen for C. trachomatis, and nested PCR was used to amplify a fragment of the ompA gene for serotype confirmation. Bacterial cultivation and sensitivity tests were conducted based on the 2015 version of the Clinical and Laboratory Standards Institute. Adenovirus, herpes simplex virus, cytomegalovirus, and Epstein-Barr virus were screened by RT-PCR. Among the 35 students with trachoma, 8 came from the Jianshetang Primary School and 27 came from the Central Primary School. Two novel C. trachomatis B serotypes (GenBank accession numbers KU737520 and KU737521) were detected based on a sequence analysis of the ompA gene. Single C. trachomatis infections accounted for 42.86% (9/21) of the cases, and infections with multiple bacteria, particularly Haemophilus influenzae, Staphylococcus aureus, Moraxella catarrhalis, and Streptococcus pneumoniae, accounted for the remaining 57.14% (12/21). Of the 14 C. trachomatis-negative samples, one was positive for adenoviral infection (serotype D) and 13 were positive for bacterial infections (H. influenzae, M. catarrhalis, S. pneumoniae, S. aureus, streptococci other than S. pneumoniae, Staphylococcus epidermidis, Corynebacterium, and Arthrobacterium). In addition to C. trachomatis, the other bacteria and virus that were detected in the boarding students of primary schools in the Qinghai Tibetan area should be emphasized in trachoma prevention and control.

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The prevalence of chlamydia trachomatis among patients with acute conjunctivitis in kasr alainy ophthalmology clinic

Cited by 4 publications

References 10 publications

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

Assessment of Association between Schizophrenia and Chlamydiaceae Using Hill Criteria

Etiological characteristics of chlamydia trachoma conjunctivitis of Primary Boarding School students in the Qinghai Tibetan area

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