The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome

Korkut, Esin; Bektaş, Mehmet; Öztaş, Erkin; Kurt, Mevlüt; Çetinkaya, Hülya; Özden, Ali

doi:10.1016/j.ejim.2010.06.004

Cited by 40 publications

(26 citation statements)

References 33 publications

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“…Celiac disease and IBS have overlapping clinical presentations, resulting in some patients with celiac disease being mistakenly diagnosed as having IBS [90,91]. The number of patients with celiac disease among those with IBS is reported to vary between 0.04% and 4.7% [92][93][94][95][96][97][98][99][100][101][102].…”

Section: Food Allergy or Intolerancementioning

confidence: 96%

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

Gundersen¹,

Hatlebakk

Hausken

2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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Section: Food Allergy or Intolerancementioning

confidence: 96%

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

Gundersen¹,

Hatlebakk

Hausken

2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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“…These studies were performed on a small patient sample, and therefore definite conclusions could not be drawn. The reported prevalence of cd in iBS patients varies among different studies, in the range of 0.7-4.7% (18,(25)(26)(27)(28). in the present study, the prevalence of cd among iBS patients was found to be 0.04%.…”

Section: A B Discussionmentioning

confidence: 99%

The prevalence of celiac disease in patients with irritable bowel syndrome

El‐Salhy

Lomholt-Beck

Gundersen³

2011

Mol Med Rep

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Abstract. The diagnosis of irritable bowel syndrome (iBS) is based on symptom assessment such as the rome iii criteria. It is sometimes difficult to clinically distinguish IBS from adult-onset celiac disease (cd). individuals with cd presenting with relatively vague abdominal symptoms are at risk of been dismissed as having iBS. This study aimed to investigate the prevalence of patients with CD among those that fulfill the rome iii criteria for iBS from among patients referred to the gastroenterology section of our hospital over the last 5 years. The study included a total of 968 patients with an average age of 32 years (range 18-59 years). Females constituted 95% of all patients. duodenal biopsies were obtained during standard gastroscopy. Sections from these biopsies were stained with haematoxylin and eosin and immunostained for human leucocytes cd45 using the avidin-biotin complex (aBc) method. The sections were then histopathologically examined. Four patients had cd: one with Marsh type 3b, and 3 with Marsh type 1. all four of these patients were positive for tissue transglutminase antibodies (anti-t-TG) iga and were females aged 24, 20, 36 and 38 years. These 4 patients fulfilled the Rome III criteria for the sub-type iBS-diarrhea. This amounts to a prevalence of 0.4% of CD in IBS patients. The present findings support the notion that iBS patients should be routinely examined for cd. This applies to all subtypes of iBS.

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“…In CD patients, this is due to gluten allergy, while in IBS, the effect is attributed to the long sugar polymer fructan in the wheat (29). The prevalence of CD in IBS varies in different studies and varies between 0.04 to 4.7% (71)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)(82). Regardless of the number of CD patients among patients diagnosed with IBS, we believe that IBS patients should be routinely screened for CD.…”

Section: The Role Of Diet In the Pathogenesis Of Ibsmentioning

confidence: 99%

The role of diet in the pathogenesis and management of irritable bowel syndrome (Review)

El‐Salhy

Østgaard

Gundersen³

et al. 2012

Int J Mol Med

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Abstract. Most patients with irritable bowel syndrome (IBS) believe that diet plays a significant role in inducing IBS symptoms and desire to know what foods to avoid. It has been found that the intake of calories, carbohydrates, proteins and fat by IBS patients does not differ from that of the background population. IBS patients were found to avoid certain food items that are rich in fermentable oligo-, di-and monosacharides and polyols (FODMAPs), but they did have a high consumption of many other FODMAP-rich food items. The diet of IBS patients was found to consist of a low calcium, magnesium, phosphorus, vitamin B2 and vitamin A content. There is no consistent evidence that IBS patients suffer from food allergy, nor is there documented evidence that food intolerance plays a role in IBS symptoms. Abnormalities in gut hormones have been reported in IBS patients. As gut hormones control and regulate gastrointestinal motility and sensation, this may explain the abnormal gastrointestinal motility and visceral hypersensitivity reported in these patients. Guidance concerning food management which includes individually based restrictions of FODMAP-rich food items and individual evaluation of the effects of protein-, fat-and carbohydrate-rich/poor diets may reduce IBS symptoms.

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The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome

Cited by 40 publications

References 33 publications

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

Diet and Irritable Bowel Syndrome, with a Focus on Appetite-Regulating Gut Hormones

The prevalence of celiac disease in patients with irritable bowel syndrome

The role of diet in the pathogenesis and management of irritable bowel syndrome (Review)

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