The Prevalence of Celiac Disease Autoantibodies in Patients With Systemic Lupus Erythematosus

Rensch, Michael J.; Szyjkowski, Ronald; Shaffer, Richard T.; Fink, Sean; Kopecky, Craig; Grissmer, Linda; Enzenhauer, Raymond; Kadakia, Shailesh C.

doi:10.1111/j.1572-0241.2001.03753.x

Cited by 74 publications

(40 citation statements)

References 12 publications

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“…[23] SLE association to CD is likely rare as one study did not find hidden cases in 103 patients with SLE. [24] A more recent study from Northern Ireland did not reveal clinical evidence of SLE among a cohort of 60 celiac disease patients. [25] While gastrointestinal manifestations of SLE are common in both adults and children, [26][27][28] CD is relatively rare among this patient population but should be considered in the setting of malabsorption symptoms.…”

Section: Inflammatory Arthritismentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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Section: Inflammatory Arthritismentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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“…The increased presence of antigliadin antibodies in patients with SLE has been considered to represent false positivity, which is consistent with the presence of false positive autoantibodies for numerous other conditions in patients with SLE. 15 One study by Lerner et al 38 observed that in a group of patients with CD, 23% had anti-dsDNA and 14% had anticardiolipin antibodies. However, a study by Caglar et al 39 found no significant differences in the frequency of a number of anticytoplasmic and antinuclear antibodies between patients with CD and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…1 In children ages 2.5 to 15 years this prevalence has been reported as between 0.3% and 1.3%. [2][3][4] Studies have shown an association between CD and numerous autoimmune and rheumatic conditions including rheumatoid arthritis, 5,6 juvenile idiopathic arthritis (JIA), [7][8][9][10] autoimmune thyroiditis, [10][11][12] autoimmune thrombocytopenic purpura, hemolytic anemia, 6 vasculitis, 5,6 polymyositis and dermatomyositis, 13,14 systemic lupus erythematosus (SLE), 5,6,15,16 scleroderma, 5,6 mixed connective tissue disease, 5 diabetes mellitus, [17][18][19][20][21][22] Sjögren syndrome, 6,10,23,24 and dermatitis herpetiformis. 24 Among the connective tissue disorders, only Sjögren syndrome appears to share the HLA DQ2/DQ8 haplotype with CD.…”

Section: What This Study Addsmentioning

confidence: 99%

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

et al. 2015

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BACKGROUND AND OBJECTIVES: Current clinical guidelines do not consider patients with rheumatic conditions to be at high risk for celiac disease (CD) despite numerous reported associations between the two in adults and children. The objective of this study was to evaluate the prevalence of CD among patients presenting for pediatric rheumatology evaluation.METHODS: A total of 2125 patients presenting for initial evaluation by the Division of Pediatric Rheumatology at the Hospital for Special Surgery between June 2006 and December 2013 were screened for CD as a part of the standard initial serologic evaluation. The charts of these patients were evaluated retrospectively at the end of this period.RESULTS: 36 patients (30 girls, 6 boys, mean age 9.4 6 4.3 years, range 2-16 years) received a diagnosis of CD after serologic testing and evaluation by pediatric gastroenterology. Eight additional patients with known diagnoses of CD presented during this time period. The total prevalence of CD over this 6.5-year period was 2.0%. The most common presenting complaints among patients diagnosed with CD were myalgias, arthralgias, and rash. Less frequently, patients reported gastrointestinal complaints including abdominal pain, nausea, and diarrhea. All patients reported improvement or complete resolution of their musculoskeletal symptoms after initiation of a gluten-free diet.CONCLUSIONS: This study identified 36 new cases of CD among children presenting for rheumatology evaluation, for an overall prevalence rate of 2.0%. The majority of patients who ultimately received a diagnosis of CD presented with extraintestinal manifestations. These results underscore the importance of screening children presenting for rheumatology evaluation for CD. WHAT'S KNOWN ON THIS SUBJECT:Associations have been reported between celiac disease (CD) and numerous autoimmune conditions in adults and children. However, current screening guidelines do not consider patients with rheumatic diseases to be at high risk for CD. WHAT THIS STUDY ADDS:The prevalence of CD in children presenting for rheumatology evaluation was found to be 2% by routine serologic screening. The majority of screening-detected CD cases had no CD-associated symptoms. Gluten restriction was found to relieve some musculoskeletal complaints.

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“…3 Those with a lack of speci¢city for coeliac disease will result in an inappropriately high number of referrals for duodenal biopsy. 4,5 Similarly, any test with a low sensitivity will miss an unacceptably large number of cases.…”

Section: Introductionmentioning

confidence: 99%