The prevalence of bacterial infection in acute rhinosinusitis: A Systematic review and meta‐analysis

Smith, Stephanie Shintani; Ference, Elisabeth H.; Evans, Charlesnika T.; Tan, Bruce K.; Kern, Robert C.; Chandra, Rakesh K.

doi:10.1002/lary.24709

Cited by 51 publications

(39 citation statements)

References 74 publications

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“…The study had some major limitations. It did not include some important and relevant risk factors [18][19][20]. Occupation could have given valuable information as well as zoonotic link to ENT diseases [17].…”

Section: Discussionmentioning

confidence: 99%

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

et al. 2018

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Background and objectives: The magnitude of health problems related to ear, nose and throat (ENT) in Bangladesh has not been estimated in a larger scale and very little is known about the prevalence and types of ENT diseases. Some studies, however, addressed the prevalence of otitis among school children and very few of them reported hearing defect. This study aims to assess the overall types of ENT diseases encountered by the otolaryngologists at a referral or tertiary hospital.

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Section: Discussionmentioning

confidence: 99%

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

et al. 2018

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“…In different studies, the patients' purulent discharge, nasal obstruction and fullness, and pressure and pain in face have been considered as main criteria for diagnosing acute sinusitis (Lemiengre, van Driel, Merenstein, Young, & De Sutter, 2012;Riechelmann, Giotakis, & Kral, 2013;Nematian-Samani, & Mosges, 2014;Smith, Ference, Evans, Tan, Kern, & Chandra, 2015). In a study the efficacy and side effects of 500 mg azithromycin taken daily for 3 and 6 days were compared with those of co-amoxiclav 500/125 mg taken 3 times a day for 10 days with regard to treatment of acute sinusitis in adults .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy and Side Effects of Azithromycin and Co-Amoxiclav in the Treatment of Acute Sinusitis in Adults: A Randomized Clinical Trial

Amani¹,

Mohammadi-Najafabadi²,

Ahmadi³

2016

GJHS

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Background: Regarding high prevalence of common cold and sinusitis in Chaharmahal and Bakhtiari Province and the lack of studies on patients referring hospitals in this province, this study was conducted to determine and compare the efficacy and side effects of azithromycin and co-amoxiclav. Methods:This study was a double-blinded randomized clinical trial. The study population of this clinical trial was consisted of 90 patients with acute sinusitis aged 12-65 years. At least two major criteria or one major criterion and two minor criteria with duration of at least 7 days and at most 28 days, were some of the sinusitis diagnostic criteria for inclusion of the patients into the study. The patients were examined for symptoms prior to and twice after the treatment. The treatment was administration with 500 mg azithromycin tablet per day for three days in group 1 (G1) and 625 mg co-amoxiclav tablet every 8 h for 10 days in group 2 (G2). The data were analyzed by repeated measures analysis of variance, independent t-test, and chi-square in Stata software and P < 0.05 was considered significant. Results:Mean±Standard deviation age of all patients was 32.14±9.91 years. Out of 90 participants in the study, 50 (55.56%) were male and the rest were female. The patients' symptoms were quantitatively similar in the two groups (22.3±2 and 22.2±1.9 in G1 and G2, respectively) prior to the intervention. The score at second examination decreased to 3.7±2.1 in G1 and to 9.4±2.7 in G2, significantly different from that prior to intervention and between the two groups (P<0.001). Although the score decreased in the two groups at third examination, it was not significant in the two groups (P=0.652). The cure rate in azithromycin group was derived 87.5% and 88%, and in co-amoxiclav group 32.4% and 83.3% at the days 5 and 10 of treatment, respectively. The most prevalent side effects in the two groups were diarrhea and nausea. The prevalence of diarrhea was obtained 21% and 33% in G1 and G2, respectively. Conclusion:No significant difference in side effects was seen between the two groups. Although the cure was faster in the patients treated with azithromycin than those treated with co-amoxiclav, co-amoxiclav is still considered as adequately working against acute sinusitis bacterial pathogens. In view of this efficacy, co-amoxiclav seems to lead to no drug resistance and could be used to treat the patients.

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“…However, a number of cases, particularly those that are severe, recurrent, or chronic, have a bacterial etiology and need appropriate antimicrobial treatment to avoid complications or frequent exacerbations. (3)(4)(5) Typically, antibiotics are given by mouth or intravenously. However, the systemic use of these drugs is frequently accompanied by the development of related adverse events that can significantly worsen a patient's clinical condition, increase disease duration, require further therapies, and increase costs.…”

Section: Introductionmentioning

confidence: 99%

Inhaled Antibiotic Therapy for the Treatment of Upper Respiratory Tract Infections

Esposito

Rosazza

Sciarrabba

et al. 2017

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a significant impact on the quality of life of patients and their families, and have placed an escalating financial burden on the global healthcare system. Most URTIs are caused by viruses and require only symptomatic treatment. However, a number of cases, particularly those that are severe, recurrent, or chronic, have a bacterial etiology and need appropriate antimicrobial treatment to avoid complications or frequent exacerbations. To ensure therapeutic antibiotic concentration without any significant systemic drug exposure, the direct delivery of antibiotics to the upper respiratory tract by inhalation is a potential solution. The main aim of this review is to determine if and when aerosolized antibiotics can be effectively used to treat URTIs in noncystic fibrosis (non-CF) patients. There is a lack of strong evidence for the use of nebulized antibiotics to treat URTIs in non-CF patients. The only disease for which positive results have been reported is chronic RS in adults. However, conflicting conclusions have been drawn, and many problems related to the drug of choice, dosages, duration of treatment, and the best device for administration remain unsolved. Further studies are needed to better determine when and through which treatment modalities inhaled antibiotics can positively modify the course of chronic RS.

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The prevalence of bacterial infection in acute rhinosinusitis: A Systematic review and meta‐analysis

Cited by 51 publications

References 74 publications

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

Comparison of Efficacy and Side Effects of Azithromycin and Co-Amoxiclav in the Treatment of Acute Sinusitis in Adults: A Randomized Clinical Trial

Inhaled Antibiotic Therapy for the Treatment of Upper Respiratory Tract Infections

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