The prevalence of bacteraemia-related retinal lesions in seriously ill patients

Çelik, İ̇lhami; Cihangiroğlu, Mustafa; Yılmaz, Turgut; Köhle, Ülkü; Akbulut, Ayhan

doi:10.1016/j.jinf.2005.04.006

Cited by 8 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the incidence of chorioretinitis may be overestimated in our study. Celik et al noted that 14% of patients in a septic nonbacteremic group had retinal lesions similar to those included as chorioretinitis here (26). However, differentiating between infectious chorioretinitis and retinal lesions of noninfectious cause is difficult.…”

Section: Discussionmentioning

confidence: 96%

Incidence and Risk Factors of Ocular Infection Caused by Staphylococcus aureus Bacteremia

Jung

Lee

et al. 2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Staphylococcus aureus bacteremia (SAB) often leads to ocular infections, including endophthalmitis and chorioretinitis. However, the incidence, risk factors, and outcomes of ocular infections complicated by SAB are largely unknown. We retrospectively analyzed the incidence and risk factors of ocular involvement in a prospective cohort of patients with SAB at a tertiary-care hospital. Ophthalmologists reviewed the fundoscopic findings and classified the ocular infections as endophthalmitis or chorioretinitis. During the 5-year study period, 1,109 patients had SAB, and data for 612 (55%) who underwent ophthalmic examinations within 14 days after SAB onset were analyzed. were independent risk factors for ocular involvement. Of the 47 patients with ocular involvement who could communicate, only 17 (36%) had visual disturbances. Two-thirds of the patients with endophthalmitis (10/15 patients) were treated with intravitreal antibiotics combined with parenteral antibiotics, whereas all of the patients with chorioretinitis were treated only with systemic antibiotics. No patients became blind. Among 42 patients for whom follow-up assessments were available, the ocular lesions improved in 29 (69%) but remained the same in the others. Ocular involvement was independently associated with death within 30 days after SAB onset. Ocular involvement is not uncommon among patients with SAB. Routine ophthalmic examinations should be considered for patients with infective endocarditis or metastatic infections caused by SAB. Staphylococcus aureus bacteremia (SAB) is associated with significant morbidity and mortality rates. It often leads to metastatic infections that result in clinically significant complications. Bones, joints, the kidneys, and the lungs are common sites of metastatic infections (1), and SAB occasionally involves the eyes (2). Previous studies showed that the incidences of metastatic infections due to SAB range between 13% and 39% (3-10). Searching for metastatic infections in SAB is crucial, because such infections determine the duration of antibiotic therapy required and often necessitate adjuvant therapy such as drainage or surgery (11).Ocular involvement in SAB is a critical condition because it may cause vision loss. A few case series have described ocular involvement in SAB. Ness and Schneider reported on 3 patients with endogenous methicillin-resistant S. aureus (MRSA) endophthalmitis with poor prognoses (12), whereas another more recent report on 7 patients described better outcomes after treatment (13). To the best of our knowledge, however, there has been no study of the incidence, risk factors, and outcomes of ocular involvement in SAB. In addition, it has not yet been clearly determined whether clinicians should perform ophthalmic examinations for all patients with SAB. Therefore, we aimed to investigate the incidence and risk factors for ocular involvement in patients with SAB.(This study was presented in part at ICAAC/ICC 2015, San Diego, CA, 17 to 21 September 2015.) MATERIALS AND METHODSStudy design...

show abstract

Section: Discussionmentioning

confidence: 96%

Incidence and Risk Factors of Ocular Infection Caused by Staphylococcus aureus Bacteremia

Jung

Lee

et al. 2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Results of a survey 30 of human pediatric patients hospitalized for systemic disease in a tertiary referral center revealed no cases of uveitis or septic endophthalmitis in patients with sepsis or other systemic infection. [31][32][33][34]36,37 One of the limitations of the study reported here was the relatively small population and the high proportion of foals that had multiple systemic and ophthalmic diagnoses, which made meaningful data analysis challenging. [31][32][33] In adult humans, sepsis is also associated with conjunctival hemorrhages, retinitis, panuveitis, and endophthalmitis.…”

Section: Discussionmentioning

confidence: 98%

Ophthalmic lesions in neonatal foals evaluated for nonophthalmic disease at referral hospitals

Labelle¹,

Hamor²,

Townsend³

et al. 2011

javma

View full text Add to dashboard Cite

show abstract

“…Uveitis has been commonly associated with human sepsis and it has been considered as an indirect predictor for survival in neonatal medicine 19–22 . In foals, although it is generally accepted that uveitis may be a frequent finding in septic neonates, there are no studies establishing its real incidence and clinical relevance.…”

Section: Discussionmentioning

confidence: 99%

“…It is a common practice to perform a complete ocular examination in all septic human patients 19,21 . Unfortunately, ophthalmologic examinations in horses are not routinely performed, what might underdiagnose many ocular disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Uveitis has been commonly associated with human sepsis and it has been considered as an indirect predictor for survival in neonatal medicine. [19][20][21][22] In foals, although it is generally accepted that uveitis may be a frequent finding in septic neonates, there are no studies establishing its real incidence and clinical relevance. The present study shows that the incidence of uveitis in septic foals is high, and that uveitis is related with poor prognosis in newborn foals.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Uveal Inflammation in Septic Newborn Foals

Leiva

Peña

Armengou

et al. 2010

Journal of Veterinary Internal Medicine

View full text Add to dashboard Cite

Background: Septicemia in humans is described as a leading cause of uveitis, which eventually can induce blindness. Hypothesis/Objectives: Uveal inflammatory findings could be related to sepsis severity in newborn foals and might be used as an indirect indicator for survival.Animals: Seventy-four septic foals, 54 nonseptic foals, and 42 healthy foals. Methods: Prospective observational clinical study. A detailed blinded, ophthalmic examination was performed by boarded ophthalmologists on all admitted newborn foals. Foals were grouped as septic (when blood culture resulted positive or the sepsis score was 14), nonseptic, and controls. Based on blood culture results, the septic group was subdivided into bacteremic and nonbacteremic foals.Results: Blood culture was performed in 62/74 septic foals, from which 35 (56%) were bacteremic and 27 (44%) were nonbacteremic. Anterior uveitis was diagnosed in a significantly (P o .005) higher number of septic/bacteremic foals (14/35, 40%) than in septic/nonbacteremic foals (5/27, 19%), nonseptic foals (4/54, 7%), and control foals (0%). Anterior chamber fibrin was only observed in 4/14 (29%) septic/bacteremic foals with anterior uveitis. Anterior uveitis was also associated with posterior uveitis in 6/35 (19%) septic/bacteremic foals. The diagnosis of uveitis was related to nonsurvival (P 5 .001, odds ratio 5 6.2, 95% confidence interval 5 2.1-18.2).Conclusions and Clinical Importance: Anterior uveitis is highly prevalent in septic newborn foals, especially in those with a positive blood culture, and it should be considered as a survival prognostic factor.

show abstract

The prevalence of bacteraemia-related retinal lesions in seriously ill patients

Cited by 8 publications

References 15 publications

Incidence and Risk Factors of Ocular Infection Caused by Staphylococcus aureus Bacteremia

Incidence and Risk Factors of Ocular Infection Caused by Staphylococcus aureus Bacteremia

Ophthalmic lesions in neonatal foals evaluated for nonophthalmic disease at referral hospitals

Uveal Inflammation in Septic Newborn Foals

Contact Info

Product

Resources

About