Abstract:The prevalence of rhinoconjunctivitis was high in adolescence. Children with rhinoconjunctivitis with and without comorbidities were frequently sensitized. Children with asthma without concomitant allergic rhinoconjunctivitis were rarely sensitized.
“…The same prevalence was reported in the BAMSE study at 12 years of age, and it was 18% at 11 years of age in the Avon Longitudinal Study of Parents and Children . On the other hand, some studies, like the UK Manchester Asthma and Allergy Study and the Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis, reported a higher prevalence of above 30% . Different definitions of current allergic rhinitis can partly account for these differences.…”
“…The same prevalence was reported in the BAMSE study at 12 years of age, and it was 18% at 11 years of age in the Avon Longitudinal Study of Parents and Children . On the other hand, some studies, like the UK Manchester Asthma and Allergy Study and the Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis, reported a higher prevalence of above 30% . Different definitions of current allergic rhinitis can partly account for these differences.…”
“…Skin sensitization to cow's milk, hen's egg, and peanut at 12 months of age was associated with increased risk of adolescent sensitization and probable FA at 12 and 18 years among subjects from an Australian birth cohort . A collective body of evidence suggests a progression from AD and FA to wheezing, asthma, and sensitization to inhalant allergens at school age . Dietary intake in early life combined with atopy history may have an impact on the risk of developing asthma.…”
The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depend on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution, and infections. Preventive strategies may include avoidance measures, diet supplements, and early complementary food introduction. Overall, the management of allergic diseases has been improving to date toward a patient's tailored approach. This review will cover the current understanding of risk factors, prediction, and management of food allergy and atopic dermatitis in childhood and discuss how these may contribute to the modification of the natural history of food allergy and atopic dermatitis.
“…Of the 190 not participating in the 14-years follow-up investigation significant less were in social class 1–2 and significantly more had mothers who smoked during pregnancy and at birth. A detailed description of the 14 years follow-up investigation was reported earlier [21]. Fig.…”
BackgroundRhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have investigated rhinoconjunctivitis, but only few studies have evaluated the risk factors for non-allergic rhinoconjunctivitis in children finding family history of atopic diseases and gender to be of importance. The aim of this study was to investigate possible risk factors in early life for rhinoconjunctivitis, allergic as well as non-allergic, in adolescence.MethodsThe children in the Danish Allergy Research Center cohort were examined eight times from birth to 14 years of age. Visits included questionnaire-based interview, clinical examination, skin prick test and specific IgE. We used univariate and multivariate logistic regression to investigate the relationship between early-life risk factors and the development of rhinoconjunctivitis, allergic as well as non-allergic, in adolescence.ResultsFollow-up rate at 14-years was 66.2%. The prevalence of rhinoconjunctivitis was 32.8%. Family history of atopic diseases (aOR 2.25), atopic dermatitis (aOR 3.24), food allergy (aOR 3.89), early sensitization to inhalant and food allergens (aOR 2.92 and aOR 3.13) and male gender (aOR 1.90) were associated with allergic rhinoconjunctivitis but not with non-allergic rhinoconjunctivitis. Early environmental tobacco exposure was inversely associated with rhinoconjunctivitis (aOR 0.42), allergic (aOR 0.47) as well as non-allergic (aOR 0.43).ConclusionDifferent patterns of associations were revealed when stratifying rhinoconjunctivitis in allergic and non-allergic suggesting that allergic rhinoconjunctivitis and non-allergic-rhinoconjunctivitis are different phenotypes.
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