The Prevalence of Asymptomatic and Symptomatic Peripheral Arterial Disease and Peripheral Arterial Disease Risk Factors in the US Population

Aponte, Judith

doi:10.1097/hnp.0b013e3182157c4a

Cited by 18 publications

(9 citation statements)

References 45 publications

(37 reference statements)

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“…Traditional lipid parameters, such as abnormal rates of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), are common risk factors for PAD [ 5 ]. Notably, an increasing number of studies have indicated the development and progression of atherosclerosis under conditions of abnormal nontraditional lipid profiles.…”

Section: Introductionmentioning

confidence: 99%

Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

et al. 2020

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Background Data on the relationship between nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] and the risk of peripheral artery disease (PAD) are limited. The present study investigated the relationship of nontraditional lipid indices with PAD in hypertensive patients. Methods This cross-sectional study was performed among 10,900 adults with hypertension. Participants were diagnosed with PAD when their ankle-brachial index (ABI) was < 0.9. The association between nontraditional lipid profiles and PAD was examined using multivariate logistic regression analysis and the restricted cubic spline. Results All nontraditional lipid indices were independently and positively associated with PAD in a dose-response fashion. After multivariable adjustment, the per SD increments of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C were all significantly associated with 37, 14, 40, and 24% higher risk for PAD, respectively. The adjusted ORs (95% CI) for PAD were 1.77 (1.31, 2.40), 1.71 (1.25, 2.34), 2.03 (1.50, 2.74), and 1.70 (1.25, 2.31) when comparing the highest tertile to the lowest tertile of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, respectively. Conclusions Among Chinese hypertensive adults, all nontraditional lipid indices were positively associated with PAD, and the LDL-C/HDL-C and TC/HDL-C ratios were better than the other nontraditional lipid indices for predicting PAD. These findings may improve the risk stratification of cardiovascular disease and dyslipidemia management. Trial registration CHiCTR, ChiCTR1800017274. Registered 20 July 2018.

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Section: Introductionmentioning

confidence: 99%

Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

et al. 2020

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“…Epidemiological studies of the prevalence of PAD in the general population indicate that many cases of PAD will not exhibit overt symptoms of PAD such as intermittent claudication [36,37]. In people with heart failure, it could be expected that due to functional limitations, many people may not ambulate to the extent to which symptoms of PAD occur, thereby precluding identification of PAD in this patient group.…”

Section: Discussionmentioning

confidence: 98%

Peripheral arterial disease and chronic heart failure: a dangerous mix

et al. 2012

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Chronic heart failure (CHF) is associated with a high comorbidity burden, adverse impact on quality of life and high health care utilisation. Peripheral arterial disease (PAD) and CHF share many risk, pathophysiological and prognostic features, and each has been associated with increased morbidity and mortality. PAD often goes undetected, and yet in spite of the availability of screening tools, this is not commonly considered in CHF care. A review of the electronic databases Medline, CINAHL and Cochrane CENTRAL was undertaken using the MeSH terms peripheral arterial disease, peripheral vascular disease, intermittent claudication and heart failure to identify studies examining the prevalence and clinical outcomes of coexisting PAD in patients with CHF. Five studies were identified. There are limited data describing the impact of PAD on CHF outcomes. As PAD may contribute to decreased capacity to exercise and other self-care behaviours, identifying those at risk and providing appropriate therapy are important. Based on this review, patients who are smokers and those with diagnosed coronary heart disease and diabetes should be targeted for the screening of PAD.

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“…The prevalence of PAD is increasing worldwide, and DM is an important risk factor for PAD [22,23]. Most patients with PAD are asymptomatic, but they have elevated risk for mortality [22][23][24]. In Taiwan, annual screening for foot complications is recommended in the clinical guidelines and in the P4P program for patients with DM [13,25].…”

Section: Discussionmentioning

confidence: 99%

Use of the Combination of Ankle-brachial Index and Percentage of Mean Arterial Pressure at Ankle for Improving Prediction of All-cause Mortality in type 2 Diabetes Mellitus

Sheu

Lee

2020

Preprint

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Background: Peripheral artery disease (PAD) in lower extremities is a common complication in type 2 diabetes and has shown to be associated with mortality. The ankle-brachial index (ABI) is a simple noninvasive method to screen PAD, but has limited sensitivity. We hypothesized that using the percentage of mean arterial pressure (%MAP) and the ABI in combination would improve prediction of mortality.Methods: We retrospectively collected the data of patients with type 2 diabetes who had undergone measurement of ABI and %MAP at our hospital. We separated the cohort into four groups according to the ABI and %MAP values, and examined these indices were associated with mortality.Results: A total of 5101 patients (mean age, 65 ± 11 years) were enrolled. During the follow-up period (median, 22.9 months), 266 (4.8%) of enrolled patients died. The combination of ABI and %MAP was significantly better at predicting mortality than ABI alone. (C index: 0.62 [95% CI: 0.57, 0.65] vs. 0.57 [95% CI: 0.53, 0.62], P = 0.038). In multivariate analysis (with ABI >0.90 and %MAP ≤45% as the reference group), the highest risk of mortality was seen in patients with ABI ≤0.90 and %MAP >45% (hazard ratio = 1.983 [95% CI: 1.380, 2.848], P < 0.001).Conclusions: Adding %MAP to ABI appears to significantly improve the predictive ability for all-cause mortality in patients with type 2 diabetes.

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The Prevalence of Asymptomatic and Symptomatic Peripheral Arterial Disease and Peripheral Arterial Disease Risk Factors in the US Population

Cited by 18 publications

References 45 publications

Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

Peripheral arterial disease and chronic heart failure: a dangerous mix

Use of the Combination of Ankle-brachial Index and Percentage of Mean Arterial Pressure at Ankle for Improving Prediction of All-cause Mortality in type 2 Diabetes Mellitus

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