The Prevalence of Allergic Sensitization to Triatoma Protracta (Heteroptera: Reduviidae) in a Southern California, USA, Community1

Marshall, Neil A.; Liebhaber, Myron; Dyer, Zeb; Saxon, Andrew

doi:10.1093/jmedent/23.2.117

Cited by 27 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One-milliliter fractions were collected from a flow rate of 1 ml/min. Three immunologically active fractions were identified by ELISA, using banked serum samples from patients with confirmed allergy to T. protracta (7), and a goat anti-human IgG-HRP conjugate (Boehringer Mannheim, Mannheim, Germany). Sera were obtained from four patients all of whom had at least three life-threatening episodes of anaphylaxis.…”

Section: Ag Purification and Amino-terminal Sequence Analysismentioning

confidence: 99%

“…In the U.S., allergic reactions have been associated with T. protracta, T. rubida, T. recurva, T. sanguisuga, T. gerstaekeri, and Paratriatoma hirsuta (6,7). Allergic sensitization, demonstrated by anti-Triatoma IgE Ab, may develop in as many as 7% of individuals residing within the range of these insects (7).…”

mentioning

confidence: 99%

“…Allergic sensitization, demonstrated by anti-Triatoma IgE Ab, may develop in as many as 7% of individuals residing within the range of these insects (7). The expansion in both seasonal and perennial human incursions into chaparral or woodland habitats of T. protracta in the western U.S. has increased the number of persons at risk for Triatoma hypersensitivity; it is estimated that as many as 30,000 persons in California are at risk for anaphylaxis from this insect (7).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Identification, Cloning, and Recombinant Expression of Procalin, a Major Triatomine Allergen

Paddock

McKerrow

Hansell³

et al. 2001

The Journal of Immunology

View full text Add to dashboard Cite

Among the most frequent anaphylactic reactions to insects are those attributed to reduviid bugs. We report the purification and identification of the major salivary allergen of these insects. This 20-kDa protein (procalin) is a member of the lipocalin family, which includes salivary allergens from other invertebrates and mammals. An expression system capable of producing reagent quantities of recombinant allergen was developed in Saccharomyces cerevisiae. Antisera produced against recombinant protein cross-reacts with ELISA with salivary allergen. Recombinant Ag is also shown to react with sera from an allergic patient but not with control sera. By immunolocalization, the source of the salivary Ag is the salivary gland epithelium and its secretions.

show abstract

Section: Ag Purification and Amino-terminal Sequence Analysismentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Identification, Cloning, and Recombinant Expression of Procalin, a Major Triatomine Allergen

Paddock

McKerrow

Hansell³

et al. 2001

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Persons typically are attacked by T. protracta while sleeping indoors, and those bitten repetitively may develop severe and sometimes life-threatening allergic reactions. 53 At the CHR, 9 (10.6%) of the 85 study subjects reported exposure to this bug (Lane RS, unpublished data), and therefore the 20% prevalence of AASA to T. protracta appears reasonable because many people bitten nocturnally would be unaware of their exposure unless they subsequently developed an allergic reaction. Similarly, 6.7% of residents inhabiting a community in a coastal chaparral-oak woodland area in southern California were found to be at risk for developing serious immediate hypersensitivity reactions to the bites of T. protracta.…”

Section: 51mentioning

confidence: 99%

“…Similarly, 6.7% of residents inhabiting a community in a coastal chaparral-oak woodland area in southern California were found to be at risk for developing serious immediate hypersensitivity reactions to the bites of T. protracta. 53 The anthropophilic feeding habits of T. protracta and its close association with the dusky-footed woodrat, a proven reservoir host of B. burgdorferi, 25,26 prompted us to evaluate the possible association of antibodies to T. protracta with Lyme disease. The fact that elevated levels of antibodies to this bug were not correlated or associated with either Lyme disease seropositivity or probable Lyme disease suggests that it does not transmit B. burgdorferi to humans.…”

Section: 51mentioning

confidence: 99%

Anti-arthropod saliva antibodies among residents of a community at high risk for Lyme disease in California.

Lane¹,

Moss²,

Hsu³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. The role of the western black-legged tick (Ixodes pacificus) versus that of other potential arthropod vectors in the epidemiology of Lyme disease was evaluated by determining the prevalence of anti-arthropod saliva antibodies (AASA) among residents (n ϭ 104) of a community at high-risk (CHR). Salivary gland extracts prepared from I. pacificus, the Pacific Coast tick (Dermacentor occidentalis), the western cone-nose bug (Triatoma protracta), and the western tree-hole mosquito (Aedes sierrensis) were used as antigens in an ELISA. Sera from 50 residents of the San Francisco Bay region in northern California and 51 residents of Imperial County in southern California served as comparison groups. The prevalence of AASA ranged from 2% for A. sierrensis to 79% for I. pacificus in study subjects, 0% for D. occidentalis to 36% for I. pacificus among residents of the San Francisco Bay region, and 6% for I. pacificus to 24% for A. sierrensis in residents of Imperial County. The associations between AASA and demographic factors, potential risk factors, probable Lyme disease, and seropositivity for Borrelia burgdorferi were assessed for 85 members of the CHR. Seropositivity for I. pacificus and B. burgdorferi were significantly correlated, the relative risk of seropositivity to B. burgdorferi was about 5 (31% versus 6%) for subjects who were seroreactive to I. pacificus, nearly every individual who was seropositive for B. burgdorferi had elevated levels of antibodies to I. pacificus, and the mean titer for antibodies to I. pacificus was significantly higher for subjects seropositive versus those seronegative for B. burgdorferi. Together, these findings support the widely held belief that I. pacificus is the primary vector of B. burgdorferi for humans in northern California, and they demonstrate the utility of the AASA method as an epidemiologic tool for studying emerging tick-borne infections.Anti-tick saliva antibody has been used as a biologic marker of tick exposure that is a risk factor for seropositivity to the Lyme disease spirochete Borrelia burgdorferi.

show abstract

Advances in Triatomine Bug Ecology in Relation to Chagas’ Disease

Barrett

1991

Advances in Disease Vector Research

View full text Add to dashboard Cite

The Prevalence of Allergic Sensitization to Triatoma Protracta (Heteroptera: Reduviidae) in a Southern California, USA, Community1

Cited by 27 publications

References 0 publications

Identification, Cloning, and Recombinant Expression of Procalin, a Major Triatomine Allergen

Identification, Cloning, and Recombinant Expression of Procalin, a Major Triatomine Allergen

Anti-arthropod saliva antibodies among residents of a community at high risk for Lyme disease in California.

Advances in Triatomine Bug Ecology in Relation to Chagas’ Disease

Contact Info

Product

Resources

About