The prevalence of abdominal aortic aneurysms in the rural/urban population in central Poland — Gniewkowo Aortic Study

Dereziński, Tadeusz; Fórmankiewicz, Bartosz; Migdalski, Arkadiusz; Brazis, Paweł; Jakubowski, Grzegorz; Woda, Łukasz; Jawień, Arkadiusz

doi:10.5603/kp.a2017.0071

Cited by 14 publications

(27 citation statements)

References 14 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In both the patient cohort used for the micro-array RNA expression (Table 2) and the patient cohort population study we show a gender and age difference between AAA and occlusive disease patients with an overrepresentation of males in the AAA group as compared to the occlusive disease group (85.5% versus 66.9%, p < 0.001) [20]. This observation has also been described earlier as it is known that the incidence of AAA rises rapidly after the age of 55 years in men [10,13,15]. Therefore, our data reflect the actual AAA and occlusive disease patient population.…”

Section: Discussionsupporting

confidence: 81%

“…It is unclear if genetic factors affected in TAA also play a role in AAA, though a recent study identified overlapping genetic defects between AAA and familial TAA [12]. The prevalence of AAA is~6-9% among men older than 65 years of age [13][14][15] and is usually higher than for TAA with variations between populations globally [16]. Yet, in contrast to TAA, AAA causative genes have not been identified yet [17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease

IJpma

Riet

Luijtgaarden

et al. 2019

JCDD

View full text Add to dashboard Cite

Abdominal aortic aneurysms (AAA), are usually asymptomatic until rupture causes fatal bleeding, posing a major vascular health problem. AAAs are associated with advanced age, male gender, and cardiovascular risk factors (e.g. hypertension and smoking). Strikingly, AAA and AOD (arterial occlusive disease) patients have a similar atherosclerotic burden, yet develop either arterial dilatation or occlusion, respectively. The molecular mechanisms underlying this diversion are yet unknown. As this knowledge could improve AAA treatment strategies, we aimed to identify genes and signaling pathways involved. We compared RNA expression profiles of abdominal aortic AAA and AOD patient samples. Based on differential gene expression profiles, we selected a gene set that could serve as blood biomarker or as pharmacological intervention target for AAA. In this AAA gene list we identified previously AAA-associated genes COL11A1, ADIPOQ, and LPL, thus validating our approach as well as novel genes; CXCL13, SLC7A5, FDC-SP not previously linked to aneurysmal disease. Pathway analysis revealed overrepresentation of significantly altered immune-related pathways between AAA and AOD. Additionally, we found bone morphogenetic protein (BMP) signaling inhibition simultaneous with activation of transforming growth factor β (TGF-β) signaling associated with AAA. Concluding our gene expression profiling approach identifies novel genes and an interplay between BMP and TGF-β signaling regulation specifically for AAA.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease

IJpma

Riet

Luijtgaarden

et al. 2019

JCDD

View full text Add to dashboard Cite

show abstract

“…We set to study these two parameters starting as a study of 1000 individuals presenting to have abdominal ultrasonography at radiology department (elective). The introduction of population-based screening reduced mortality associated with AAA by 45% [8].…”

Section: Discussionmentioning

confidence: 99%

Frequency of abdominal aortic aneurysm in persons who have been examined with ultrasound at Kasr Al-Ainy Hospitals: a single center pilot study

et al. 2019

View full text Add to dashboard Cite

Introduction: To know frequency of abdominal aortic aneurysm (AAA) using ultrasound and clarify associated risk factors in 1000 Egyptians. Material and methods: Prospective study. 1000 patients aged 50 years or more (mean: 57.97 ± [7.68]) were examined by B-mode ultrasound at our radiology department to measure suprarenal maximum diameter of the abdominal aorta (wall to wall measurement) and to identify the occurrence of AAA (aneurysms were defined as 1.5 times the mean diameter). Demographic data and risk factors were also noted. Results: Mean aortic diameter in study population was 18.9 ± (3.2) mm. AAA diameter was 28.3 mm. Frequency of AAA was 1.5%. AAA prevalence: 2.35% in males versus 0.75% in females. Prevalence of AAA in different age groups: < 60 years (n = 653), 60-70 (n = 282), > 70 years (n = 65) was 6 (0.9%), 6 (2.1%), 3 (4.6%) respectively. Patients with AAA were older (P < 0.001), more often male (P < 0.001), smokers (P < 0.001). Conclusion: Study showed that mean aortic diameter was 18.9 mm and AAA is present in 1.5% of the study population which was less than that seen in previously conducted studies in other countries.

show abstract

“…We excluded 82 records because they were case reports/case series, 12 were comments, 10 were editorials, 9 clinical guidelines, 80 were systematic reviews, 13 were meta-analysis, 573 were about other topics. 40 papers were considered for systematic review (Figure 1) 14 papers were considered in Meta-Analysis: 13 prevalence studies and 1 case-control hospitalbased study [4,[11][12][13]15,18,34,35,44,47,50,52,54,56].…”

Section: Systematic Review Of the Literature And Meta-analysismentioning

confidence: 99%

“…Other more frequent risk factors associated with AAA are: age, gender, hypertension, family history and coronary artery disease [8]. Although the role of the hypertension is still controversial [9][10][11][12], while, in some studies hypertension is a risk factor [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Abdominal Aortic Aneurysm in Population-Based Studies: A Systematic Review and Meta-Analysis

Altobelli¹,

Rapacchietta²,

Profeta³

et al. 2018

Preprint

View full text Add to dashboard Cite

Abdominal aortic aneurysm (AAA) represents an important public health problem with a prevalence between 1.3% and 12.5%. Several population-based randomized trials have evaluated ultrasound screening for AAA providing evidence of a reduction in aneurysm-related mortality in the screened population. The aim of our study was to perform a systematic review and meta-analysis of the risk factors for AAA. We conducted a systematic review of observational studies and we performed a meta-analysis that evaluated the following risk factors: gender, smoking habits, hypertension, diabetes mellitus, Coronary Artery Disease and family history of AAA. Abdominal aortic aneurysm prevalence is higher in smokers and in males. It is important to underline that all countries, where AAA screening was set up, had high income level and the majority belong to Western Europe (United Kingdom, Sweden, Italy, Poland, Spain and Belgium). Abdominal aortic aneurysm screening is fundamental for public health. It would avoid deaths, ruptures, and emergency surgical interventions if abdominal aortic aneurysm was diagnosed early in the population target for screening.

show abstract

The prevalence of abdominal aortic aneurysms in the rural/urban population in central Poland — Gniewkowo Aortic Study

Abstract: The prevalence of AAA in men aged 65 years and older is seemingly larger than in previously conducted studies, while among men 60-64 years of age and women aged ≥ 65 it is similar. Older age, smoking, and a history of MI/ACS were the most important risk factors of AAA occurrence.

Cited by 14 publications

References 14 publications

Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease

Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease

Frequency of abdominal aortic aneurysm in persons who have been examined with ultrasound at Kasr Al-Ainy Hospitals: a single center pilot study

Risk Factors for Abdominal Aortic Aneurysm in Population-Based Studies: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About