The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant<i>Staphylococcus aureus</i>

Park, Se Young; Kim, Shin Moo; Park, Seok Don

doi:10.5021/ad.2012.24.1.32

Cited by 36 publications

(31 citation statements)

References 23 publications

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“…Mupirocin resistance may be helpful in the spread of multidrug resistance through co-selection with other resistance genes. Previous reports found that mupirocin-resistant S. aureus isolates were multi-resistant to other antimicrobial agents, such as ciprofloxacin, clindamycin, and tetracycline (21,22). Similarly, in present study, mupirocinresistant S. epidermidis were also multi-drug resistant to other antimicrobial agents.…”

Section: Discussionsupporting

confidence: 62%

Emergence of Staphylococcus epidermidis Clinical Isolates with Resistance to Both Mupirocin and Fusidic Acid

Lin

Chen

Jin

et al. 2018

Jundishapur J Microbiol

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Section: Discussionsupporting

confidence: 62%

Emergence of Staphylococcus epidermidis Clinical Isolates with Resistance to Both Mupirocin and Fusidic Acid

Lin

Chen

Jin

et al. 2018

Jundishapur J Microbiol

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“…Cadilla et al found an association between strains of mupirocin-resistant MRSA and resistance to three or more non-beta-lactam antimicrobial classes (21). Mupirocin-resistant MRSA strains isolated from several hospitals in Korea were also resistant to ciprofloxacin, clindamycin, and tetracycline (22).…”

mentioning

confidence: 99%

High Prevalence of Mupirocin Resistance in Staphylococcus aureus Isolates from a Pediatric Population

Antonov

Garzon

Morel

et al. 2015

Antimicrob Agents Chemother

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Topical mupirocin is used widely to treat skin and soft tissue infections and to eradicate nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). Few studies to date have characterized the rates of S. aureus mupirocin resistance in pediatric populations. We retrospectively studied 358 unique S. aureus isolates obtained from 249 children seen in a predominantly outpatient setting by the Division of Pediatric Dermatology at a major academic center in New York City between 1 May 2012 and 17 September 2013. Mupirocin resistance rates and the associated risk factors were determined using a logistic regression analysis. In our patient population, 19.3% of patients had mupirocin-resistant S. aureus isolates at the time of their first culture, and 22.1% of patients with S. aureus infection had a mupirocin-resistant isolate at some time during the study period. Overall, 31.3% of all S. aureus isolates collected during the study period were resistant to mupirocin. Prior mupirocin use was strongly correlated (odds ratio [OR] ‫؍‬ 26.5; P ‫؍‬ <0.001) with mupirocin resistance. Additional risk factors for mupirocin resistance included methicillin resistance, atopic dermatitis (AD), epidermolysis bullosa (EB), immunosuppression, and residence in northern Manhattan and the Bronx. Resistance to mupirocin is widespread in children with dermatologic complaints in the New York City area, and given the strong association with mupirocin exposure, it is likely that mupirocin use contributes to the increased resistance. Routine mupirocin testing may be important for MRSA decolonization strategies or the treatment of minor skin infections in children.

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“…This confirms the effectiveness of O. glandulosum oil treatment. In addition, there is an urgent need to look for other substances to replace mupirocin because of the spread of S. aureus resistant strains to this molecule (Park et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of the essential oil of Origanum glandulosum Desf against skin infections With PVL-producing Staphylococcus aureus strains in mice

Khadir¹,

Bendahou²,

Benbelaïd³

et al. 2013

Afr. J. Microbiol. Res.

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Skin and soft tissue infections (SSTI) caused by staphylococcal toxins including Panton-Valentine leukocidin (PVL) have increased these last years. Treatment of these complicated infections is often difficult. The search for new methods and new antimicrobial substances is necessary. Natural products such as essential oils appear among the possible solutions. The objective of our work was to prove the effectiveness of treatment of these infections with essential oils in vivo on Wistar rats; we have chosen the oil of Origanum glandulosum from Algeria to perform this treatment because of its antiseptic properties. The treatment was done on infections induced in Wistar rats using PVL producing Staphylococcus aureus strain isolated from Tlemcen University Hospital. The results of our experiment have shown a significant decrease in the number of colonies collected from rats treated by the concentrations of 1 and 5% of O. glandulosum essential oil. The treatment of skin infections especially wounds caused by PVL positive S. aureus is possible with the essential oil of O. glandulosum which seems to be effective in eradicating the germ from infected wounds.

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The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-ResistantStaphylococcus aureus

Cited by 36 publications

References 23 publications

Emergence of Staphylococcus epidermidis Clinical Isolates with Resistance to Both Mupirocin and Fusidic Acid

Emergence of Staphylococcus epidermidis Clinical Isolates with Resistance to Both Mupirocin and Fusidic Acid

High Prevalence of Mupirocin Resistance in Staphylococcus aureus Isolates from a Pediatric Population

Efficacy of the essential oil of Origanum glandulosum Desf against skin infections With PVL-producing Staphylococcus aureus strains in mice

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