The Prevalence and Symptoms Characteristic of Functional Constipation Using Rome III Diagnostic Criteria among Tertiary Education Students

Lim, Ying Jye; Jamaluddin, Rosita; Chieng, Jin Yu; Hazizi, Abu Saad

doi:10.1371/journal.pone.0167243

Cited by 19 publications

(23 citation statements)

References 44 publications

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“…Female predominance was also shown in a recent epidemiological study in FC patients based on Rome III Criteria, with a higher prevalence in female (17.4%) compared to male students (12.5%) . In univariate logistic regression analysis, FC was significantly associated with sex (odds ratio [OR] 1.48, 95% confidence interval [CI] 1.06‐2.06).…”

Section: Resultsmentioning

confidence: 59%

European society of neurogastroenterology and motility guidelines on functional constipation in adults

Serra

Pohl

Azpiroz

et al. 2019

Neurogastroenterology Motil

134

127

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Introduction: Chronic constipation is a common disorder with a reported prevalence ranging from 3% to 27% in the general population. Several management strategies, including diagnostic tests, empiric treatments, and specific treatments, have been developed. Our aim was to develop European guidelines for the clinical management of constipation.Design: After a thorough review of the literature by experts in relevant fields, including gastroenterologists, surgeons, general practitioners, radiologists, and experts in gastrointestinal motility testing from various European countries, a Delphi consensus process was used to produce statements and practical algorithms for the management of chronic constipation. 2 of 33 | SERRA Et Al. | INTRODUC TI ONChronic constipation is a common disorder with a reported prevalence ranging from 3% to 27% in the general population. 1,2 Its prevalence increases with age 3,4 and consequently is expected to rise over the next few years, 5 in parallel with the predicted increase in longevity of the European population. Constipation is a symptom that may have diverse etiologies, and for this reason, several diagnostic approaches and treatment options are available, ranging from simple lifestyle changes and general measures to sophisticated pharmacological treatments and surgical interventions. 6 In an attempt to unify the health care received by the population across Europe, the European Society of Neurogastroenterology and Motility (ESNM) decided to develop European guidelines to help physicians to take the best decisions to improve the quality of health in patients suffering from common functional and motor disorders. In this document, we present the ESNM guidelines for chronic constipation, which are intended to be a useful tool for the management of this condition in the general population in Europe. In order to produce comprehensive guidelines addressing the different aspects related with constipation, experts from European countries working in related fields developed relevant statements after a thorough review of the available literature, and final recommendations and management algorithms were produced following a Delphi consensus process. | ME THODS | ParticipantsA chair (Jordi Serra) and co-chair (Daniel Pohl) were commissioned by the ESNM Steering Committee to develop the guidelines. A panel of 12 experts from different European countries, constituted by gastroenterologists, surgeons, general practitioners, radiologists, and experts in gastrointestinal (GI) motility testing, was invited by the chairs to participate in the development of the guidelines. Each expert was assigned to develop a specific area of the document (see below) and to establish a team with one or two co-workers to complete the assigned task. The final ESNM guidelines working group was composed of 13 experts and 9 co-authors. | The Delphi consensusEach expert and co-worker conducted a thorough review of the literature in their specific field of expertise. The following areas were covered by the different subgrou...

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Section: Resultsmentioning

confidence: 59%

European society of neurogastroenterology and motility guidelines on functional constipation in adults

Serra

Pohl

Azpiroz

et al. 2019

Neurogastroenterology Motil

134

127

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“…Female patients with IBS also showed alterations in intrinsic oscillation in the INS and its functional connectivity . Like IBS and many other FGID, FC is more prevalence in women with a mean female to male ratio of 2.1:1 . To the best of our knowledge, only one resting‐state fMRI (RS‐fMRI) study from our group has been performed in patients with FC and revealing brain abnormalities in regions implicated in emotional process modulation, somatic and sensory processing, and motor control .…”

Section: Introductionmentioning

confidence: 95%

“…16,17 Like IBS and many other FGID, FC is more prevalence in women with a mean female to male ratio of 2.1:1. 18,19 To the best of our knowledge, only one resting-state fMRI (RS-fMRI) study from our group has been performed in patients with FC and revealing brain abnormalities in regions implicated in emotional process modulation, somatic and sensory processing, and motor control. 10 No sex-related differences in patients with FC have been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Sex‐related differences in resting‐state brain activity and connectivity in the orbital frontal cortex and insula in patients with functional constipation

Jin

Duan

et al. 2019

Neurogastroenterology Motil

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Functional magnetic resonance imaging (fMRI) has been used to investigate sex‐related differences in brain abnormalities in patients with irritable bowel syndrome (IBS). Like IBS, women with functional constipation (FC) are 2.1 times as many as men. No study has been performed yet to examine sex‐related differences in brain activity and connectivity in patients with FC. Here, we employed resting‐state fMRI with amplitude of low‐frequency fluctuation (ALFF) to investigate brain functional differences in 51 patients with FC (34 females) and 52 healthy controls (34 females). Results showed abdominal pain and abdominal distension correlated with trait (TAI) and state (SAI) anxiety ratings in the female FC group, and abdominal distension correlated with sensation of incomplete evacuation in the male FC group. Two‐way ANOVA revealed sex effects on ALFF in precentral gyrus, thalamus, insula (INS), and orbital frontal cortex (OFC, PFWE < 0.05). Post hoc test showed that the female FC group had lower ALFF than males in these brain regions (P < 0.01), and ALFF in INS and OFC was correlated with abdominal pain and difficulty of defecation, respectively. Seed voxel correlation analysis showed that the female FC group had weaker connectivity than males between INS and lateral OFC (lOFC). INS‐lOFC connectivity was negatively correlated with the anxiety score in the female FC group and was negatively correlated with abdominal distension in the male FC group. These findings provide the first insight into sex‐related differences in patients with FC and highlight that INS and OFC play an important role in modulating the intrinsic functional connectivity of the resting brain network showing that this role is influenced by sex.

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“…Prior to the intervention study, a cross-sectional study has been carried out as part of this project to identify the eligible participants. As part of the study, the prevalence of functional constipation among respondents from tertiary education institution in Malaysia was revealed as 16.2% [ 59 ]. In the present study, a 12-week treatment period with a combination of LP01, BB12, and inulin-oligofructose which formed synergistic effects was found to significantly improve the functional constipation symptoms within the synbiotics group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Synbiotics among Constipated Adults in Serdang, Selangor, Malaysia—A Randomised, Double-Blind, Placebo-Controlled Trial

et al. 2018

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Synbiotics approach complementarily and synergistically toward the balance of gastrointestinal microbiota and improvement in bowel functions. A randomised, double-blind, placebo-controlled study was conducted to examine the effects of a synbiotics supplement among constipated adults. A total of 85 constipated adults, diagnosed by Rome III criteria for functional constipation were randomised to receive either synbiotics (n = 43) or placebo (n = 42) once daily (2.5 g) in the morning for 12 weeks. Eight times of follow-up was conducted every fortnightly with treatment response based on a questionnaire that included a record of evacuation (stool frequency, stool type according to Bristol Stool Form Scale), Patients Assessment on Constipation Symptoms (PAC-SYM), and Patients Assessment on Constipation Quality of Life (PAC-QOL). There were no significant differences in stool evacuation, but defecation frequency and stool type in treatment group were improved tremendously than in placebo group. While the treatment group was reported to have higher reduction in severity of functional constipation symptoms, the differences were not statistically significant. Dietary supplementation of synbiotics in this study suggested that the combination of probiotics and prebiotics improved the functional constipation symptoms and quality of life although not significant. This was due to the high placebo effect which synbiotics failed to demonstrate benefit over the controls.

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The Prevalence and Symptoms Characteristic of Functional Constipation Using Rome III Diagnostic Criteria among Tertiary Education Students

Cited by 19 publications

References 44 publications

European society of neurogastroenterology and motility guidelines on functional constipation in adults

European society of neurogastroenterology and motility guidelines on functional constipation in adults

Sex‐related differences in resting‐state brain activity and connectivity in the orbital frontal cortex and insula in patients with functional constipation

Effects of Synbiotics among Constipated Adults in Serdang, Selangor, Malaysia—A Randomised, Double-Blind, Placebo-Controlled Trial

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