The Prevalence and Severity of Obstructive Sleep Apnea in Severe Obesity: The Impact of Ethnicity

Leong, Wen B.; Arora, Teresa; Jenkinson, D; Thomas, Ajit; Punamiya, Vikas; Banerjee, Dev; Taheri, Shahrad

doi:10.5664/jcsm.2978

Cited by 58 publications

(47 citation statements)

References 28 publications

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“…[9][10][11][12][13][14][15][16][17][18][19][20][21] Two other studies compared the prevalence of OSA in South Asians and White Europeans in the context of the metabolic syndrome and/or obesity rather than diabetes, and the results were conflicting. 35,36 In one, the prevalence of OSA was 28.3% and there was no difference between South Asians and White Europeans. This study was conducted in a primary care population, however, and utilized the Berlin Sleep questionnaire, 36 whereas our study utilized home-based sleep studies offering more in-depth assessment of OSA.…”

Section: Discussionmentioning

confidence: 91%

“…Another study reported a higher prevalence of OSA in South Asians compared to White Europeans (85% versus 66%), despite using the same methodology as ours in diagnosing OSA. 35 There are several factors that may explain this discrepancy. The patients in this study were recruited from a weight management/bariatric clinic rather than a diabetes clinic.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Amin

Ali

Altaf

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives:To assess and compare obstructive sleep apnea (OSA) prevalence in South Asians and White Europeans with type 2 diabetes mellitus (T2DM). Secondary aims included exploring possible causes for observed ethnic differences. Methods: A cross-sectional study of patients with T2DM recruited from secondary care diabetes clinics. OSA was defined as an apnea-hypopnea index (AHI) ≥ 5 events/h using home-based, multi-channel respiratory monitoring. Results: Two hundred thirty-four patients (105 South Asian and 129 White Europeans) were studied. The prevalence of mild, moderate, and severe OSA in South Asians was 36.2% (n = 38/105), 9.5% (n = 10/105), and 5.7% (n = 6/105) respectively. After adjustment, OSA was associated with a higher body mass index in South Asians. OSA was significantly less common in South Asians compared to White Europeans Conclusions: South Asians with T2DM are at considerable risk of OSA. OSA in South Asians was associated with obesity. However, OSA prevalence was lower in South Asians than in White Europeans. Obesity measures accounted for the observed ethnic differences. Examining factors contributing to ethnic differences will be important to inform screening and treatment strategies. Keywords: ethnicity, obesity, sleep apnea, type 2 diabetes Citation: Amin A, Ali A, Altaf QA, Piya MK, Barnett AH, Raymond NT, Tahrani AA. Prevalence and associations of obstructive sleep apnea in South Asians and White Europeans with type 2 diabetes: a cross-sectional study.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Amin

Ali

Altaf

et al. 2017

Journal of Clinical Sleep Medicine

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“…Previous studies have linked BMI with OSA, although most of the participants in these reports were obese 1,34,35) . It has also been shown that subjects with OSA have a high prevalence of CVD [3][4][5][6] .…”

Section: Discussionmentioning

confidence: 67%

Relationships between Nocturnal Intermittent Hypoxia, Arterial Stiffness and Cardiovascular Risk Factors in a Community-based Population: The Toon Health Study

Alberto

Tanigawa

Maruyama

et al. 2014

JAT

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Aim: Nocturnal intermittent hypoxia (NIH), a primary marker of obstructive sleep apnea, has increasingly been linked with cardiovascular morbidity and mortality. The purpose of this study was to investigate the association between NIH and arterial stiffness as measured according to the cardio-ankle vascular index (CAVI) based on cardiovascular risk factors in a Japanese community-dwelling population. Methods: We conducted a cross-sectional study in Toon city among 684 men and 1,241 women 30-79 years of age. The severity of NIH was defined as mild or moderate-to-severe according to five or 15 events/hour on the 3% oxygen desaturation index (ODI), respectively. Increased arterial stiffness was diagnosed according to a CAVI of ≥ 9. Results: The number of subjects with no, mild and moderate-to-severe NIH was 1,348 (70%), 451 (23%) and 126 (7%), respectively. Increased arterial stiffness was detected in 21.9% of the participants. The multivariable-adjusted odds ratio (95% CI) of severe NIH related to an increased CAVI in comparison with a 3% ODI of ＜5 was 1.36 (0.82-2.23). The stratified logistic regression analysis showed that the multivariable-adjusted OR of severe NIH for an increased CAVI was remarkably increased in the individuals with a BMI of ≥ 25 (OR = 2.53, 1.08-5.96; p = 0.03). An interaction test showed a trend for an overweight status to be a modifier of the association between OSA and increased arterial stiffness (p = 0.05). Conclusions: NIH has a tendency to promote increased arterial stiffness as measured according to the CAVI, especially in overweight subjects.

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“…Studies point out that Asian subjects who have Obstructive sleep apnea have a greater severity of the condition compared to age and gender controlled groups of whites [17] . Ethnicity and further racial variations of craniofacial anatomical features have been found to determine the rates of occurrence and severity of obstructive sleep apnea between groups.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Obstructive Sleep Apnea and the Nasofacial Anthropometry of Sikkimese Subjects

Mukherjee¹

2018

jmscr

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The Prevalence and Severity of Obstructive Sleep Apnea in Severe Obesity: The Impact of Ethnicity

Cited by 58 publications

References 28 publications

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Relationships between Nocturnal Intermittent Hypoxia, Arterial Stiffness and Cardiovascular Risk Factors in a Community-based Population: The Toon Health Study

The Relationship between Obstructive Sleep Apnea and the Nasofacial Anthropometry of Sikkimese Subjects

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