The prevalence and severity of pain in cancer

Daut, Randall L.; Cleeland, Charles S.

doi:10.1002/1097-0142(19821101)50:9<1913::aid-cncr2820500944>3.0.co;2-r

Cited by 520 publications

(197 citation statements)

References 7 publications

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“…We assumed that the incidence of pain in cancer patients was at least 50% on the basis of previous results. 1,2,14 Considering that this estimation was performed to calculate the number of patients within a validity rate of AE1.5% at a statistical significance of 0.05 and confidence interval of 95%, the required number of patients was 4269. With a dropout rate of 20%, the corrected required number of patients was at least 5337.…”

Section: Participantsmentioning

confidence: 99%

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Change in Cancer Pain Management in Korea Between 2001 and 2006: Results of Two Nationwide Surveys

Hong

Roh

Kim

et al. 2011

Journal of Pain and Symptom Management

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Context. In Korea, many health care professionals have shown increased concern about the management of cancer pain. Five years after a pain management guideline was distributed to Korean physicians, the Korean Society of Hospice and Palliative Care evaluated the change in cancer pain management. The period evaluated was between 2001 and 2006.Methods. We did a prospective, cross-sectional cancer pain survey on the change of the pain prevalence and pain intensity, its impact on daily activities and the adequacy of pain management between 2001 and 2006.Results. Overall, 7565 patients were enrolled from 72 cancer hospitals in the 2001 cancer pain survey and 7245 patients were enrolled from 63 cancer hospitals in the 2006 cancer pain survey. The overall prevalence of cancer pain and the percentage of patients reporting a negative pain management index were significantly decreased in the 2006 cancer pain survey compared with the 2001 cancer pain survey (44.9% vs. 52.1%, P < 0.0001 and 41.6% vs. 45.0%, respectively, P ¼ 0.0005). However, in 2006, physicians did not prescribe analgesics to 25.8% of the patients with severe pain and they did not adjust the prescribed analgesics properly in 47.4% of the patients with severe pain.Conclusion. Some improvement in cancer pain management was noted during the five years between 2001 and 2006. However, all of the physicians who care for

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Section: Participantsmentioning

confidence: 99%

“…1,2 Pain management is an important component of cancer treatment. Untreated or undertreated pain impairs physical and psychological health, functional status, and quality of life, in addition to increasing the economic cost.…”

Section: Introductionmentioning

confidence: 99%

Change in Cancer Pain Management in Korea Between 2001 and 2006: Results of Two Nationwide Surveys

Hong

Roh

Kim

et al. 2011

Journal of Pain and Symptom Management

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“…Pain will often be the first symptom reported (Daut and Cleeland, 1982;Miser et al, 1987) and becomes more prevalent and more severe with progression of the disease until up to 85% of patients with terminal cancer report severe pain (Foley, 2000;Portenoy, 1989). Bone is a common site of tumor metastases, particularly in patients with lung, breast, and prostate cancer (Rubens, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Bone is a common site of tumor metastases, particularly in patients with lung, breast, and prostate cancer (Rubens, 1998). Patients with bone metastases report cancerrelated pain more often than patients with local and regional disease (Ahles et al, 1984;Daut and Cleeland, 1982). Frequently, the first indication of bone metastases is pain, and pain is the most frequent symptom for patients with bone cancer (Pecherstorfer and Vesely, 2000).…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia

Hamamoto

Giridharagopalan

Simone

2007

European Journal of Pharmacology

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Patients with cancer frequently report pain that can be difficult to manage. This study examined the antihyperalgesic effects of a cannabinoid receptor agonist, CP 55,940, in a murine model of cancer pain. Implantation of fibrosarcoma cells into and around the calcaneous bone in mice produced mechanical hyperalgesia (decreased paw withdrawal thresholds and increased frequency of paw withdrawals). On day 13 after implantation, mechanical hyperalgesia, nociception, and catalepsy were assessed. Mice were randomly assigned to receive CP 55,940 (0.01-3 mg/kg, i.p.) or vehicle and behavioral measures were redetermined. CP 55,940 dose-dependently attenuated tumor-evoked mechanical hyperalgesia. To examine the effect of catalepsy on the antihyperalgesic effect of CP 55,940, mice with tumor-evoked hyperalgesia were pretreated with the dopamine agonist apomorphine prior to administration of CP 55,940. Apomorphine attenuated the cataleptic effect of CP 55,940 but did not attenuate its antihyperalgesic effect. In a separate group of mice with tumorevoked hyperalgesia, administration of the dopamine antagonist spiperone produced catalepsy that was ~2.5 fold greater than that produced by CP 55,490. Whereas this dose of CP 55,940 completely reversed tumor-evoked mechanical hyperalgesia, spiperone only attenuated mechanical hyperalgesia by ~35%. Thus, the cataleptic effects of CP 55,940 did not fully account for its antihyperalgesic effect. The antihyperalgesic effect of CP 55,940 was mediated via the cannabinoid CB 1 but not CB 2 receptor. Finally, repeated administration of CP 55,940 produced a short-term and a longer term attenuation of tumor-evoked hyperalgesia. These results suggest that cannabinoids may be a useful alternative or adjunct therapy for treating cancer pain.

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“…1,2 Pain is the most frequent complication of cancer 3 and can lead to reduced quality of life 4 and increased utilisation of medical services. 5 Cancer pain management is frequently suboptimal despite effective treatments being available.…”

Section: Introductionmentioning

confidence: 99%

Utilising out-of-hours primary care for assistance with cancer pain: a semi-structured interview study of patient and caregiver experiences

et al. 2015

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BackgroundPain is the most frequent complication of cancer and an important reason for out-ofhours (OOH) primary care contacts by patients with established cancer. Existing quantitative data give little insight into the reason for these contacts. Exploring such encounters of care could highlight ways to improve anticipatory cancer care and communication between daytime and OOH primary care services. AimTo explore the experiences, views, and opinions of patients and their caregivers who have used OOH primary care for help with managing cancer pain. Design and settingA semi-structured interview study with patients and caregivers who have utilised an OOH primary care service in Grampian, Scotland, because of pain related to cancer. MethodSemi-structured interviews with 11 patients and four caregivers (n = 15), transcribed verbatim and analysed using framework analysis and, to a lesser extent, inductive thematic analysis. ResultsSix key themes emerged: making sense of pain and predicting its likely course; beliefs about analgesics; priority daytime access; the importance of continuity of care and communication between all involved; barriers and facilitators to seeking help in the OOH period; and satisfaction/dissatisfaction with OOH care. Three prominent sub-themes were: patient knowledge; the influence of a caregiver on decision-making; and the benefits of having a palliative care summary. ConclusionEffective daytime and anticipatory care can positively influence OOH care. Interventions that aid patients in understanding cancer pain, communicating about pain, utilising analgesics effectively, and seeking appropriate and timely help may improve cancer pain management.

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The prevalence and severity of pain in cancer

Cited by 520 publications

References 7 publications

Change in Cancer Pain Management in Korea Between 2001 and 2006: Results of Two Nationwide Surveys

Change in Cancer Pain Management in Korea Between 2001 and 2006: Results of Two Nationwide Surveys

Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia

Utilising out-of-hours primary care for assistance with cancer pain: a semi-structured interview study of patient and caregiver experiences

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