The prevalence and risk factors of overactive bladder symptoms and its relation to pelvic organ prolapse symptoms in a general female population

Boer, T.A. de; Burger, Curt W.; Vierhout, Mark E.

doi:10.1007/s00192-010-1323-x

Cited by 75 publications

(55 citation statements)

References 30 publications

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“…A large, cross‐sectional study using multiple linear regression (MLR) and artificial neural networks (ANNs) reported the weak correlation between the symptom of urgency and anatomical findings . These findings confirmed previous reports suggesting that bladder and bowel dysfunction may coexist but not be causally related to prolapse . The mechanism behind the development of urinary and bowel symptoms is multifactorial, including intrinsic and extrinsic factors.…”

Section: Discussionsupporting

confidence: 73%

Relationship between pelvic floor symptoms and POP‐Q measurements

Manonai

Wattanayingcharoenchai

2015

Neurourology and Urodynamics

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Section: Discussionsupporting

confidence: 73%

Relationship between pelvic floor symptoms and POP‐Q measurements

Manonai

Wattanayingcharoenchai

2015

Neurourology and Urodynamics

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“…Fifteen studies made a specific reference to OAB . The others categorised urinary symptoms in a variety of ways including LUTS, UUI, SUI and MUI.…”

Section: Resultsmentioning

confidence: 99%

Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies

et al. 2014

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Objectives: To conduct a systematic review to determine whether there is an association between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) or overactive bladder (OAB) in women. Methods: We systematically reviewed English language observational studies on the effect of MetS (or component factors) on the presence of OAB or LUTS in women. We searched PubMed, Web of Science and The Cochrane Library with no date restrictions, checked reference lists and undertook citation searches in PubMed and Google Scholar. Studies were assessed for risk of bias. Because of heterogeneity, results were not pooled, but are reported narratively. Results: Of 27 included studies, only three looked at the link between MetS and OAB. The rest looked at links between OAB and components of MetS such as obesity or insulin resistance (n = 10), between MetS and urinary symptoms (n = 3) and between urinary symptoms and components of MetS, such as obesity (n = 14). Evidence is currently limited, but it does suggest that there may be important links between MetS and OAB and components of MetS such as obesity. Conclusions: The literature on MetS and OAB or LUTS in women is limited, and poor quality. However, the evidence available on obesity appears to support MetS as a contributor and predictor of LUTS in women. Many of the women with LUTS will be overweight and will have features of the MetS, if looked for. This provides not only an opportunity to encourage weight loss as an adjunct to therapy for the OAB symptoms but also a window of opportunity to address cardiovascular risk factors and prevent future cardiovascular morbidity and mortality. Review criteriaObservational studies examining the link between metabolic syndrome (MetS) (or components of MetS) and the presence of OAB or LUTS were identified through database and lateral searches. Message for the clinicBoth obesity and MetS have been shown to have complex links with LUTS. It is not known whether reducing insulin resistance and central obesity-related chronic inflammation and oxidative stress might prevent the onset of OAB or improve the outcome of current treatment. However, identifying women with MetS who harbour a portfolio of cardiovascular risk factors does provide an opportunity to address future cardiovascular risk, and prevent premature morbidity and mortality; although whether this will have an effect on the storage component of LUTS is unclear. The key variables to address are diet and lifestyle, especially exercise. The investigations should include a blood pressure recording, BMI and waist circumference measurement together with a lipid profile and HbA1c. These results should be transmitted to the GP for action.

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“…A possible explanation for the late occurrence of OAB symptoms might be formation of fibrosis around the tape or mesh erosion . Obviously, these symptoms could also be the result of physiological changes associated with ageing, since the prevalence of OAB increases with age …”

Section: Methodsmentioning

confidence: 99%