The prevalence and progression of mild cognitive impairment among clinic and community populations: a systematic review and meta-analysis

Hu, Chengping; Yu, Dunxi; Sun, Xiaoying; Zhang, Ming; Lin, Weihong; Qin, Hongyun

doi:10.1017/s1041610217000473

Cited by 144 publications

(130 citation statements)

References 74 publications

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“…For instance, Xia et al reported that HOTAIR can promote metastasis in renal cell carcinoma by upregulating the histone demethylase JMJD3 [30]. In addition, a meta-analysis highlighted that HOTAIR was overexpressed in cancer tissues and actively participated in cancer occurrence and development [31]. Consistent with these findings, our study also found that HOTAIR expression was significantly enhanced in ovarian cancer and that its depletion suppressed ovarian cancer cell aggressiveness; this result was also in agreement with recent evidence that highly expressed HOTAIR was connected with Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry …”

Section: Discussionmentioning

confidence: 99%

LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer

Chang¹,

Guo²,

Zhang³

et al. 2018

Cell Physiol Biochem

100

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Background/Aims: The long noncoding RNA homeobox (HOX) transcript antisense intergenic RNA (HOTAIR) has been demonstrated to be a vital modulator in the proliferation and metastasis of ovarian cancer cells, but its potential molecular mechanism remains to be elucidated. In the current study, we aimed to uncover the biological role of lncRNA HOTAIR and its underlying regulatory mechanism in the progression and metastasis of ovarian cancer. Methods: HOTAIR expression was detected by quantitative RT-PCR (qRT-PCR) and northern blotting. The SKOV3 ovarian cancer cell line was chosen for the subsequent assays. In addition, the molecular mRNA and protein expression levels were examined by qRT-PCR and western blotting. The competitive endogenous RNA (ceRNA) mechanism was validated by bioinformatics analysis and a dual luciferase reporter gene assay. Results: HOTAIR expression was significantly higher in ovarian carcinoma tissues and cell lines than in the control counterparts. Both CCND1 and CCND2 were downstream targets of miR-206. The inhibition of HOTAIR elevated the expression of miR-206 and inhibited the expression of CCND1 and CCND2. Moreover, CCND1 and CCND2 were highly expressed in ovarian cancer tissues, and their expression was positively correlated with HOTAIR expression. Finally, the functional assays indicated that the anticancer effects of miR-206 could be rescued by the simultaneous overexpression of either CCND1 or CCND2 in ovarian cancer. Conclusion: HOTAIR enhanced CCND1 and CCND2 expression by negatively modulating miR-206 expression and stimulating the proliferation, cell cycle progression, migration and invasion of ovarian cancer cells.

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Section: Discussionmentioning

confidence: 99%

LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer

Chang¹,

Guo²,

Zhang³

et al. 2018

Cell Physiol Biochem

100

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“…cell lung cancer by interacting with cell cycle-related genes independent of glycolysis [17]. Aside from this, Na et al conducted multivariate analysis that revealed ALDOA as an independent and significant prognostic factor in clear cell renal cell carcinoma [18,19].…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

miR-122-5p Inhibits the Proliferation, Invasion and Growth of Bile Duct Carcinoma Cells by Targeting ALDOA

Liu

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Bile duct cancer, although not among the most common tumors, still accounts for more and more worldwide deaths each year. By attempting to verify an overexpression of ALDOA in cholangiocarcinoma tissues and cells and explore the underlying molecular mechanism regulated by miR-122-5p, this study was designed to provide a potential molecular target in bile duct cancer treatment. Methods: Western blot and immunohistochemistry were performed to detect the ALDOA protein level in duct carcinoma tissues. The transfection efficiency was confirmed by western blot and/or RT-qPCR assay. The proliferation of bile duct carcinoma cells was determined by MTT and colony formation assay. The invasion ability of bile duct carcinoma cells was evaluated with Transwell invasion assay. Flow cytometry detected cell apoptosis of bile duct carcinoma cells. The miRNAs which modulate ALDOA were filtrated from bioinformatics software and clinical specimens. The target relationship was confirmed by dual luciferase reporter assay. Furthermore, a xenograft model was completed to verify the impact of miRNA on inhibition growth of bile duct carcinoma cells. Results: ALDOA was found up-regulated in bile duct carcinoma tissues and cells. Knockdown of ALDOA promoted the apoptosis of cells and inhibited the proliferation and invasion of bile duct carcinoma cells. Bioinformatics and clinical specimens indicated the negative correlation and targeted regulation between miR-122-5p and ALDOA. By down-regulating ALDOA, overexpression of miR-122-5p appeared to promote cell apoptosis and significantly inhibit cell proliferation, invasion in vitro and suppress the tumor growth in vivo. Conclusion: miR-122-5p inhibited proliferation and invasion of bile duct carcinoma cells and promoted cell apoptosis by targeting ALDOA expression.

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“…The characteristic pathological changes of AD (senile plaques and neurofibrillary tangles) are already present in MCI . The prevalence of MCI among the older people in China is 14.7–20.8%, and approximately one ‐third of people with MCI will progress into AD . In spite of the increasing number of people with AD and MCI among the older people in China, less than 20% of these people have ever sought medical attention and most of them still exist in the communities.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 The prevalence of MCI among the older people in China is 14.7-20.8%, 10,11 and approximately one -third of people with MCI will progress into AD. 12 In spite of the increasing number of people with AD and MCI among the older people in China, less than 20% of these people have ever sought medical attention 13 and most of them still exist in the communities. Therefore, brief and sensitive questionnaires are required to screen in communities for timely interventions.…”

mentioning

confidence: 99%

Validation study of the Alzheimer's Disease Assessment Scale‐Cognitive Subscale for people with mild cognitive impairment and Alzheimer's disease in Chinese communities

Yang

Zhang

et al. 2019

Int J Geriat Psychiatry

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Objective Our study aimed to verify the validity of the Chinese version of Alzheimer's Disease Assessment Scale‐Cognitive Subscale (ADAS‐Cog) for the community‐dwelling older people in China. Methods A total of 1276 individuals composed by 628 normal controls (NCs), 572 people living with mild cognitive impairment (MCI), and 76 people living with Alzheimer's disease (AD) were recruited for the current study. All of the participants underwent ADAS‐Cog, clinical interview and examination, Quick Cognitive Screening Scale for the Elderly, and Activities of Daily Living Scale. The sensitivity and specificity of ADAS‐Cog were calculated, and a receiver operating characteristic curve (ROC curve) was drawn to decide the optimal cutoff points of ADAS‐Cog for screening MCI and AD. Results Statistically significant differences were observed among the three groups (P <. 001, NC < MCI

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The prevalence and progression of mild cognitive impairment among clinic and community populations: a systematic review and meta-analysis

Abstract: Age and gender were observed to be associated with MCI, in which age was considered as an impact factor for DR. The strong heterogeneity may result from variations in study design and baselines. Standardized MCI criteria were suggested to systematically evaluate MCI in the future.

Cited by 144 publications

References 74 publications

LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer

LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer

miR-122-5p Inhibits the Proliferation, Invasion and Growth of Bile Duct Carcinoma Cells by Targeting ALDOA

Validation study of the Alzheimer's Disease Assessment Scale‐Cognitive Subscale for people with mild cognitive impairment and Alzheimer's disease in Chinese communities

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