The Prevalence and Prognostic Role of Vitamin D Deficiency in Patients with Acute Coronary Syndrome: A Single Centre Study in South-West of Iran

Mahdavi, Kamran; Amirajam, Zahra; Yazdankhah, Saeed; Majidi, Shahla; Adel, Mohammad Hassan; Omidvar, Bita; Alasti, Mohammad

doi:10.1016/j.hlc.2012.11.006

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…Our study could not correlate with Mahdavi K et al 14 in which they concluded that Significant (p<0.01) correlation between the vitamin D deficiency and ACS in comparison to healthy controls was recorded. As in our study the p=0.188.…”

Section: Discussioncontrasting

confidence: 96%

Study of Serum Vitamin D Level in Ischaemic Heart Disease - A Cross-Sectional Study

Patil¹,

M²,

Biradar³

et al. 2017

jemds

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BACKGROUND Vitamin D deficiency is highly prevalent worldwide, and is also noted to be high in India. Low levels of 25(OH) D, the principle circulating storage form of vitamin D, is present in as many as one third to one half of otherwise healthy middle aged to elderly population. Endothelial dysfunction plays an important role in pathogenesis of CAD and vitamin D deficiency is postulated to promote endothelial dysfunction. Because hypovitaminosis D is prevalent and easily correctable, establishing the relationship between vitamin D and risk of acute coronary Syndrome is important. Objectives-1. To estimate vitamin D levels in IHD patients, 2) To correlate vitamin D levels with complications of IHD. MATERIALS AND METHODS A Cross Sectional study of 80 patients admitted to BLDEU's Shri B. M. Patil Medical College Hospital and Research Centre, Vijayapura between December 2014 to March 2016 with diagnosis of IHD. Patients aged more than 18 years were included in studies. The Vitamin D levels were analysed in all the patients and correlated with different parameters for statistical significance. RESULTS During our study period 80 patients were assessed as mentioned above. The mean age of our study group was 58.5 ±9.6 years. Of the study population, there were 57 male patients and 23 were females accounting to 71.2 % and 28.8 % respectively. Out of 80 patients 66 had Vitamin D deficiency in 45 were males and 21 were females. In that 34 patients had heart failure with hypotension and 1 had ventricular tachycardia, I had Left Ventricular Apical clot. CONCLUSION There is a high prevalence of Vitamin D deficiency (82.5%) among acute coronary syndrome patients. The mean age group is 58.5±9.6 years. Vitamin D deficiency is associated with increased risk of complications (75.75%) in acute coronary syndromes. Vitamin D deficiency is one of the independent risk factor for acute coronary syndrome. Vitamin D deficiency is noticed more in STEMI. Vitamin D deficiency in females was more common than compared to males.

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Section: Discussioncontrasting

confidence: 96%

Study of Serum Vitamin D Level in Ischaemic Heart Disease - A Cross-Sectional Study

Patil¹,

M²,

Biradar³

et al. 2017

jemds

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“…In our study there was significant relation between the deficiency of vitamin D and the severity of CAD, as the mean serum vitamin D level in the first group "positive for CAD" was 20.1 ng/mL, which was significantly lower than its value (29.7 ng/mL) in the second group "negative for CAD" (P<0.001). Mahdavi et al also found a considerably high prevalence of vitamin D deficiency in patients with acute coronary syndrome [19]. This was in agreement with Moradi and Foroutanfar who found that the serum vitamin D level in the "positive for CAD" group was 20.98 ng/mL, a value that was significantly lower than that (30.47 ng/mL) in the "negative for CAD" group (P<0.001) [19].…”

Section: Discussionsupporting

confidence: 61%

“…Mahdavi et al also found a considerably high prevalence of vitamin D deficiency in patients with acute coronary syndrome [19]. This was in agreement with Moradi and Foroutanfar who found that the serum vitamin D level in the "positive for CAD" group was 20.98 ng/mL, a value that was significantly lower than that (30.47 ng/mL) in the "negative for CAD" group (P<0.001) [19]. This relation can be explained by the relation of CACS and plaque burden of the coronary arteries.…”

Section: Discussionmentioning

confidence: 94%

Vitamin D Levels Assessment in Relation to Coronary MDCT Angiographic Findings

Tantawy¹,

Hasanin

Farid

2019

Zagazig University Medical Journal

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Background: Although vitamin D has a major role at the skeletal mineralization, it has been implicated at cardio vascular system, owing to abundance of its receptor there. Atherosclerosis is the most presenting symptom of the cardio-vascular system that warrants the urge to detect the effect of vitamin D serum level changes in progression of the atherosclerosis. Objective is to assess the correlation between vitamin D level and coronary artery findings using MDCT. Methods: Two hundred and Fifty patients were included in our study, all of them underwent MDCT for coronary artery angiography, and then the findings were compared with vitamin D serum levels. Results: 4 % of all examined patients (n=10) had vitamin D deficiency, 44 % (n=110) had insufficient levels of vitamin D, 52 % have sufficient vitamin D level (n=130). There is significant positive correlation between Lab. vitamin D levels and coronary artery calcium score (CACS) with P<0.005. Conclusions: Vitamin D levels play significant role in modifying the risk of coronary artery involvement.

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“…Furthermore, the relatively small sample in the present study was also a contributing factor. Other studies that have focused on this issue in Iran29,30 have consistently found a relationship between coronary artery-related disorders and vitamin D deficiency, but they have not focused directly on detailed angiographic data. However, the present study showed a significant relationship between increased CACS and the severity of vitamin D abnormalities (deficiency or insufficiency).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Moradi¹,

Foroutanfar²

2017

VHRM

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BackgroundVitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD.Materials and methodsUsing a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques).ResultsThe mean age of the participants was 60.5±10.6 years and the mean serum vitamin D level was 26.2±15.9 ng/dL (range, 3.5–83.2 ng/dL). Overall, 6.1% of the participants (n=11) had vitamin D deficiency, 56.1% (n=101) had insufficient levels of vitamin D, and 37.8% (n=68) had sufficient levels of vitamin D. The mean serum vitamin D level was significantly lower in patients with severe CAD (P=0.004). The serum vitamin D level in the “positive for CAD” group was 20.98 ng/mL, significantly lower than the level in the “negative for CAD” group (30.47 ng/mL; P<0.001). The mean calcium score among participants was 533.5±87.9. Based on the Spearman test, a significant negative correlation (−0.21) was detected between the serum vitamin D level and coronary artery calcium score (CACS) (P=0.005). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and sufficient vitamin D groups (P<0.001 for both comparisons).ConclusionVitamin D deficiency was associated with coronary artery calcification and severity of coronary artery stenosis in Iranian patients.

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The Prevalence and Prognostic Role of Vitamin D Deficiency in Patients with Acute Coronary Syndrome: A Single Centre Study in South-West of Iran

Cited by 15 publications

References 17 publications

Study of Serum Vitamin D Level in Ischaemic Heart Disease - A Cross-Sectional Study

Study of Serum Vitamin D Level in Ischaemic Heart Disease - A Cross-Sectional Study

Vitamin D Levels Assessment in Relation to Coronary MDCT Angiographic Findings

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

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