Introduction: Violence against women particularly that is commited by an intimate partner is becoming a social and public health problem across the world. Studies from different countries shows that the spatial variation in distribution of domestic violence was commonly attributed by neighborhood level predictors. Despite the importance of spatial techniques, studies that employ it in Ethiopia are limited. Therefore, the aim of this study is to determine the spatial distribution and predictors of domestic violence among women aged 15-49 in Ethiopia by using EDHS 2016 dataset. Methods: Secondary data from EDHS 2016 was used to determine the spatial distribution of domestic violence in Ethiopia. Spatial auto-correlation statistics (both Global and Local Moran’s I) was used to assess the spatial distribution of domestic violence cases in Ethiopia. Spatial locations of significant clusters were identified by using Kuldorff’s Sat Scan version 9.4 software. Finally, binary logistic regression and generalized linear mixed model were fitted to identify predictors of domestic violence. Result: The study found that spatial clustering of domestic violence cases in Ethiopia with Moran’s I value of 0.26, Z score of 8.26, and P-value < 0.01. The Sat Scan analysis find out 24 significant locations of domestic violence clusters. Among this, 10 are primary clusters with RR 2.18, LLR of 39.55, and P-value < 0.01. The output from regression analysis identifies low economic status, husband/partner alcohol use, witnessing family violence as a child, marital controlling behaviors, and community acceptance of wife-beating as significant predictors of domestic violence.Conclusion and Recommendation: There is spatial clustering of d domestic violence cases in Ethiopia. Areas with a high burden of the problem should get priority for intervention. Comprehensive and collaborative action should be taken by involving stakeholders at different levels. Specific activities may include Organizing media on awareness creation and continuous education on how to maintain a stable relationship between couples and employing long term and intensive effort for transforming culture and social norms that encourage violence against woman are among the major ones.