The Prevalence and Predictors of Elevated Serum Aminotransferase Activity in the United States in 1999-2002

Ioannou, George N.; Lee, Sum P.

doi:10.1111/j.1572-0241.2005.00341.x

Cited by 293 publications

(246 citation statements)

References 11 publications

Supporting

Mentioning

211

Contrasting

Unclassified

Order By: Relevance

“…Cross-sectional studies from Western countries have reported alcohol intake to be strongly associated with increased ALT levels (Ruhl and Everhart, 2005;Ioannou et al, 2006). However, other studies did not confirm such a relationship between alcohol intake and ALT level (Nakamura et al, 1998;Adams et al, 2008).…”

Section: Introductionmentioning

confidence: 67%

Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Kim

2009

Eur J Clin Nutr

View full text Add to dashboard Cite

Background/Objectives: Obesity has been identified as an important factor of elevated alanine aminotransferase (ALT), a surrogate of non-alcoholic fatty liver disease. We investigated the relationship between obesity and elevated ALT in the general Korean population. Subjects/Methods: The study sample was comprised of 3098 Korean adults who had participated in the 2005 Korean National Health and Nutrition Examination Survey. Obesity was assessed using body mass index (BMI). Overweight (23pBMIo25) and obese (BMIX25) were defined by the International Obesity Task Force for Asian adults. ALT was measured by enzymatic methods. Elevated ALT was defined as an enzyme activity 440 IU/l for men and 431 IU/l for women. Results: Among participants, 246 (12.7%) men and 86 (7.4%) women displayed elevated ALT. BMI was significantly higher in men and women with elevated ALT than those with normal ALT (Po0.0001). The unadjusted odds ratio (OR) for elevated ALT increased according to the degree of BMI in men (OR: 1.9, 95% confidence interval (CI): 1.25-2.93 in overweight vs OR: 5.01, 95% CI: 3.49-7.21 in obese; Po0.0001) and women (OR: 2.44, 95% CI: 1.24-4.82 vs OR: 3.94, 95% CI: 2.18-7.13; Po0.0001). This trend did not differ after adjustment for putative risk factors including alcohol intake in men (OR: 1.56 vs OR: 3.47, Po0.0001) and women (OR: 1.55 vs OR: 3.10, P ¼ 0.0015). Conclusion: BMI is implicated as a strong risk factor of elevated ALT in non-diabetic Korean adults.

show abstract

Section: Introductionmentioning

confidence: 67%

Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Kim

2009

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…ALT is not an ideal marker for either the diagnosis of NAFLD or distinguishing simple steatosis from non-alcohol steatohepatitis (NASH) [13]. This was also verified in the NHANES survey where approximately 10 % of subjects have elevations of ALT and AST [14] with fatty liver being one of the most common causes [15].…”

Section: Transaminasesmentioning

confidence: 99%

Review and Recommendations for the Component Tests in the Liver Function Test Profile

Badrick

Turner

2015

Ind J Clin Biochem

View full text Add to dashboard Cite

Pathology laboratories group some tests that they perform on their high throughput biochemistry analysers into profiles of tests that are associated with different organs (e.g. liver function tests-LFT). The components of these profiles are historic and often vary between different laboratories. This can lead to confusion and begs the question of what should be in a particular profile. In community medicine profiles may be used as screening tests but some of the components of the profiles may have low sensitivity and specificity and may produce both false positives and negatives. The LFT may include components which are poor liver function tests but are sensitive to fatty liver and hence elevations may cause unnecessary concern. Harmonisation of clinical chemistry reference intervals and units is occurring now so it is time to consider a similar process for components of a profile. A proposed list of analytes to be performed in the LFT profile is given.

show abstract

“…NAFLD is now considered to be the most common cause of serum ALT elevations in the US population (9). Previous studies have shown that there is familial clustering of factors that may predispose to the development of NAFLD, NASH, and cryptogenic cirrhosis (18,19,26).…”

Section: In the Context Of Current Literaturementioning

confidence: 99%

“…In addition, there are strong ethnic associations to elevated serum ALT levels and NAFLD (12,15,16). Familial clustering of fatty liver, NASH and cryptogenic cirrhosis has been reported, further suggesting that genetic factors may play a role in the pathogenesis of NAFLD (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

“…Based on the National Health and Nutrition Examination Survey (NHANES) data, up to 7% of the adult US population has unexplained elevated ALT levels (9), most likely due to nonalcoholic fatty liver disease (NAFLD) (9). NAFLD is a spectrum of liver disease ranging from benign steatosis to nonalcoholic steatohepatitis (NASH), a progressive form of NAFLD that may lead to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) (10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parental Obesity and Offspring Serum Alanine and Aspartate Aminotransferase Levels: The Framingham Heart Study

et al. 2008

View full text Add to dashboard Cite

show abstract

The Prevalence and Predictors of Elevated Serum Aminotransferase Activity in the United States in 1999-2002

Cited by 293 publications

References 11 publications

Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Review and Recommendations for the Component Tests in the Liver Function Test Profile

Parental Obesity and Offspring Serum Alanine and Aspartate Aminotransferase Levels: The Framingham Heart Study

Contact Info

Product

Resources

About