The prevalence and influence of luteinizing hormone surges in stimulated cycles combined with intrauterine insemination during a prospective cohort study

Cantineau, Astrid E. P.; Cohlen, Bernard J.

doi:10.1016/j.fertnstert.2006.11.136

Cited by 48 publications

(32 citation statements)

References 23 publications

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“…Previous studies have reported elevated LH levels in patients undergoing IVF/ICSI treatment; however, the observed effect of these increases on pregnancy rates has differed between studies. Cantineau and Cohlen (25) observed an incidence of spontaneously elevated LH levels of 35% without a significant alteration in pregnancy rates. However, Huirne et al (26) observed reduced pregnancy rates in the presence of elevated LH levels at the time of hCG administration in patients undergoing IVF/ICSI treatment.…”

Section: Discussionmentioning

confidence: 97%

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Yin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the association between follicular fluid (FF) levels of high-mobility group box 1 (HMGB1) protein and the reproductive outcome in patients undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). FF samples were collected from the ovarian follicles (≥14 mm) of 143 infertile patients that had undergone IVF/ICSI, and the HMGB1 expression levels were determined using ELISA. Spearman's correlation and receiver operating characteristic (ROC) curve analysis were applied to analyze the results. Significantly increased levels of HMGB1 protein (7.38±2.02 vs. 6.14±2.52 ng/ml; P<0.01), endometrial thickness on the day of human chorionic gonadotropin (hCG) administration (10.3±1.3 vs. 9.7±1.7 mm; P<0.01) and retrieved oocyte counts (11.68±6.51 vs. 11.00±6.34; P<0.01) were observed in the pregnant group when compared with the non-pregnant group. Conversely, the level of luteinizing hormone on the day of hCG administration was significantly reduced in the pregnant group compared with the non-pregnant group (0.92±1.78 vs. 1.78±2.03 pmol/l, P<0.01). The ROC curve indicated a significant association between the FF level of HMGB1 protein and the pregnancy rate, with an area under the ROC curve of 0.673 (0.581-0.765; P<0.01). In addition, the HMGB1 protein level was shown to have a significant positive correlation with the endometrial thickness (r=0.170; P<0.05). Therefore, the present study indicated that the FF levels of HMGB1 protein are increased in pregnant patients and are positively correlated with endometrial thickness. Thus, FF levels of HMGB1 may be a useful factor for predicting the outcome of IVF/ICSI treatments.

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Section: Discussionmentioning

confidence: 97%

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Yin

et al. 2015

Experimental and Therapeutic Medicine

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“…Premature LH has also been linked with lower pregnancy rates compared with cycles without a premature LH surge. (8) The role of GnRH antagonist in prevention of premature LH surge is well-established. (9) Our study could not confirm the effect of GnRH antagonist on improving clinical pregnancy rate in COS-IUI cycles.…”

Section: Discussionmentioning

confidence: 99%

Effect of GNRH Antagonists on Clinical Pregnancy Rates in Controlled Ovarian Stimulation and Intrauterine Insemination

Ray¹,

Samal²

2017

jemds

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BACKGROUNDControlled Ovarian Stimulation (COS) with Intrauterine Insemination (IUI) is widely used in the treatment of unexplained infertility, mild and moderate endometriosis or male factor infertility to achieve a higher pregnancy rate. Several studies have reported conflicting results regarding the outcome of COS-IUI cycles using GnRH antagonists in terms of clinical pregnancy rate.The aim of the study is to study whether use of GnRH antagonist in IUI cycles where HMG was used for ovulation induction improved clinical pregnancy rates.

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“…Antral follicle count may be helpful in determining stimulation protocol, as it is the most reliable determinant of oocytes retrieved per starting FSH dose. Antral follicle count predicts ovarian response, not embryo quality or pregnancy [ 13 ].…”

Section: Induction Of Ovulationmentioning

confidence: 94%

“…Cantineau et al [ 13 ] studied the prevalence of premature LH surges in an IUI program. It has been concluded that 24 % of IUI cycles suffer from premature LH surge and this can result in IUI procedure cancellation.…”

Section: Ovulation Induction and Intrauterine Insemination (Iui)mentioning

confidence: 99%

Ultrasound in Follicle Monitoring for Ovulation Induction/IUI

Blankstein

Malepati

Brasch

2013

Ultrasound Imaging in Reproductive Medicine

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The prevalence and influence of luteinizing hormone surges in stimulated cycles combined with intrauterine insemination during a prospective cohort study

Cited by 48 publications

References 23 publications

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Effect of GNRH Antagonists on Clinical Pregnancy Rates in Controlled Ovarian Stimulation and Intrauterine Insemination

Ultrasound in Follicle Monitoring for Ovulation Induction/IUI

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