The prevalence and incidence of systemic lupus erythematosus in Taiwan: a nationwide population-based study

Abstract

To estimate the prevalence and incidence rate of systemic lupus erythematosus (SLE) in Taiwan by using a population-based longitudinal database from 2001 to 2011. We conducted a longitudinal Health Insurance Database (LHID) containing 1,000,000 beneficiaries’ records for calculation of prevalence and incidence rate of SLE from 2001–2011. The overall prevalence of SLE in Taiwan in 2011 is 8.11 per 10,000 people with 14.3 per 10,000 people in female and 1.62 per 10,000 people in male. The overall incidence rate of SLE is 0.74–1 per 10,000 person-years with 1.09–1.76 per 10,000 person-years in female and 0.12–0.25 per 10,000 person-years in male. The highest prevalence rate was observed at 40–49 age group in females. There were no significant differences in the overall prevalence among the urban, suburban and rural area in Taiwan while the relative risk is higher in male population living in rural area (RR 1.36, 95% C.I. 1.03–1.79, p = 0.0303). The highest income group has a lower relative risk for the prevalence of SLE (RR 0.83, 95% C.I. 0.71–0.97, p = 0.0197). The incidence rate of SLE in male in the rural area is also higher than the urban area (RR 2.34, 95% C.I. 1.3–4.22, p = 0.0046). Our study covers the longest period among the nation-wide population studies of SLE in Taiwan. The prevalence was increasing especially in the elderly.

Association of Clinical Manifestations of Systemic Lupus Erythematosus and Complementary Therapy Use in Taiwanese Female Patients: A Cross-Sectional Study

“…The worldwide prevalence of SLE varied considerably from 2 to 7 per 10,000 people [1]. In Taiwan, the reported incidence Medicina 2022, 58, 944. https://doi.org/10.3390/medicina58070944 https://www.mdpi.com/journal/medicina of SLE in 2011 was 8.1 per 10,000 people with 14.3 and 1.6 per 10,000 women and men, respectively [2]. Many organs or systems can be involved, leading to multiple clinical manifestations in patients with SLE.…”

Mycoplasma pneumonia Infection Is Associated With an Increased Risk of Systemic Lupus Erythematosus: A Nationwide, Retrospective Cohort Study

“…The incidence of SLE in adults ranges from 0.3 to 23.7 cases per 100,000 person-years around the world ( Fessel, 1988 ). In Taiwan, the annual incidence of SLE was estimated to be 4.87 per 100,000 person-years in 2003–2008 and 0.74–1 per 100,000 person-years in 2001–2011 ( Yeh et al, 2013 ; Leong et al, 2021 ). The etiology of SLE is still unclear, but infections can become environmental primers, inducing or promoting the onset and exacerbations of SLE in genetically susceptible individuals ( Esposito et al, 2014 ; Rigante et al, 2014 ; Jung and Suh, 2017 ).…”

Complex Inheritance of Rare Missense Variants in PAK2, TAP2, and PLCL1 Genes in a Consanguineous Arab Family With Multiple Autoimmune Diseases Including Celiac Disease

“…In Celiac disease (CeD), exposure to gluten, a small peptide found in barley, wheat, and rye, results in autoantibodies resulting in intestinal damage ( 5 ). The prevalence rate of the autoimmune diseases varies from 1.5 to 11 per 100,000 person-years for SLE ( 6 ), 7.3 per 100,000 person-years for T1DM ( 7 ), 27 to 273 per 100,000 for AiT ( 8 ), and 3.4% for CeD ( 9 ).…”