The prevalence and impact of brucellosis in patients with hepatitis delta virus infection: inside the  Brucella  outbreak with cirrhosis

Suvak, Burak; Dülger, Ahmet Cumhur; Suvak, Özlem; Yeşilyurt, Aysun Özel; Gültepe, Bilge; Güdücüoğlu, Hüseyin

doi:10.5114/aoms.2017.65317

Cited by 2 publications

(2 citation statements)

References 22 publications

(21 reference statements)

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“…Alcoholic cirrhosis (AC) is the most common indication for liver transplantation (LT), which accounts for approximately 33% of all primary transplants in Europe [7][8][9][10][11]. However, the molecular and cellular mechanisms underlying alcoholic liver fibrosis and its end-stage consequence, cirrhosis, are not completely understood [12][13][14][15], although it is generally believed that many factors and different types of cells interact in their development [16,17].…”

Section: Introductionmentioning

confidence: 99%

KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

et al. 2021

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Introduction: The molecular mechanisms underlying alcoholic liver fibrosis and cirrhosis are not completely understood. Hepatic fibrosis involves the interplay of diverse cells and factors, including hepatic stellate cells (HSCs), Kupffer, NK cells, and T-lymphocyte subsets. Killer-cell immunoglobulin-like receptors (KIR) are membrane receptors involved in mediation between NK and activated HSCs, regulating NK cell function through their interaction with HLA-I molecules. The aim of this study was to analyse the genetic association between KIR genes and the susceptibility to or protection from alcoholic cirrhosis (AC) in a cohort of male AC patients undergoing liver transplantation (LT) with and without concomitant viral infections. Material and methods: KIR genotyping was performed in nuclear DNA extracted from 281 AC patients and compared with 319 male controls. Results: Significant differences between total AC patients and healthy controls were only found in the case of KIR2DL2 and KIR2DS5. KIR2DL2 was significantly underrepresented in non-viral AC patients (52.6% vs. 63.3%; p = 0.015), while patients heterozygous for KIR2DL2 were also underrepresented in the non-viral AC group compared with controls (p = 0.034). KIR2DS5 was overrepresented in this group compared with healthy controls (p = 0.002). All these observations were only evident in AC patients older than 54 years old. Conclusions: Our data suggest a contrary effect of KIR2DL2 and KIR2DS5 in AC patients older than 54 years, in whom the presence of KIR2DL2 appears to be protective against AC, whereas the presence of KIR2DS5 seems to promote the fibrotic process, particularly in patients with no associated viral infection.

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Section: Introductionmentioning

confidence: 99%

KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

et al. 2021

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“…43 An intriguing combination of rare infections of the liver is exemplified by the association of hepatitis D and brucellosis. 44…”

Section: How Common Is Rare?mentioning

confidence: 99%

Access to care in rare liver diseases: New challenges and new opportunities

Jones

Sturm

Lohse

2018

Journal of Hepatology

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Patients with rare diseases are often disadvantaged, particularly those with rare liver diseases. Reasons for disadvantage include delayed or overlooked diagnosis, lack of local expertise and high-quality care, poor scientific understanding of the disease process and limited therapeutic options. In adult liver disease this can be compounded by prejudices towards patients with liver disease in general, because of a perception (incorrect for all rare liver diseases) that liver disease is lifestyle related and thus "self-inflicted". In paediatric rare liver diseases, such as biliary atresia, optimising outcomes requires a particularly timely diagnosis. Irrespective of patient age, the scientific and medical community must rise to the challenge of advancing our understanding of rare liver disease, searching for more effective and specific therapies, and providing the infrastructure to provide the best care for all patients, infants, children, young and older adults. The European Reference Network for Rare Liver Diseases is an important step in this direction.

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The prevalence and impact of brucellosis in patients with hepatitis delta virus infection: inside the Brucella outbreak with cirrhosis

Cited by 2 publications

References 22 publications

KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

Access to care in rare liver diseases: New challenges and new opportunities

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