The prevalence and factors associated with musculoskeletal disorders, in patients with sickle cell anaemia, at Mulago National Referral Hospital, Uganda

Akaro, Inyas L.; Madewo, Geoffrey; Orwotho, Norbert; Nankund, J; Byanyima, Rosemary; Samoyo, Ptk

doi:10.4314/ecajs.v21i1.139039

Cited by 3 publications

(7 citation statements)

References 19 publications

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“…This is similar to findings in the Mulago study. 11 In this study, the commonest stage of the chronic osteomyelitis was Beit Cure Classification type B3. It was also noted that the majority of cases were B-type (82.4%).…”

Section: Discussionmentioning

confidence: 64%

“…This was in concordance with the report from the Mulago study except for the lymphocyte count which was significant in their study. 11 In this study, the controls could have had other infective processes which could explain why there were no significant findings between the two groups. For the liver function test, only AST had a significant association (p = 0.01).…”

Section: Discussionmentioning

confidence: 70%

“…The Mulago study in Uganda revealed that the commonest MM was AVN of the femoral head. 11 The di erence here is that, in the Mulago study, the focus was on both paediatric and adult populations, whereas this study only focused on the paediatric population. Nevertheless, similar results were also noted in this study as all the children who presented with AVN of the femoral head were above the age of 11 years.…”

Section: Discussionmentioning

confidence: 95%

“…These findings are similar to the findings of the Mulago study in Uganda. 11 The treatment protocol for our patients to prevent VOC is hydroxyurea and long-term blood transfusion protocol. This is supported by a review done by Yawn et al, who reported that the use of hydroxyurea and transfusion protocol is highly recommended for patients who have SCD to prevent VOC.…”

Section: Discussionmentioning

confidence: 99%

“…In Uganda, a study revealed that increase in age, highly demanding physical activity status and an increased frequency of painful crises were associated factors of MM in SCD patients. 11 Zambia has a carrier rate of about 17.5% for SCD, 12 and the University Teaching Hospital currently follows up over 1050 children with SCD of whom the majority present very late with advanced MM. 13 However, no studies have been done on the potential predictors of MM of SCD patients in our setting.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

et al. 2020

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Aims Sickle cell disease (SCD) is an autosomal recessive inherited condition that presents with a number of clinical manifestations that include musculoskeletal manifestations (MM). MM may present differently in different individuals and settings and the predictors are not well known. Herein, we aimed at determining the predictors of MM in patients with SCD at the University Teaching Hospital, Lusaka, Zambia. Methods An unmatched case-control study was conducted between January and May 2019 in children below the age of 16 years. In all, 57 cases and 114 controls were obtained by systematic sampling method. A structured questionnaire was used to collect data. The different MM were identified, staged, and classified according to the Standard Orthopaedic Classification Systems using radiological and laboratory investigations. The data was entered in Epidata version 3.1 and exported to STATA 15 for analysis. Multiple logistic regression was used to determine predictors and predictive margins were used to determine the probability of MM. Results The cases were older median age 9.5 (interquartile range (IQR) 7 to 12) years compared to controls 7 (IQR 4 to 11) years; p = 0.003. After multivariate logistic regression, increase in age (adjusted odds ratio (AOR) = 1.2, 95% confidence interval (CI) 1.04 to 1.45; p = 0.043), increase in the frequency of vaso-occlusive crisis (VOC) (AOR = 1.3, 95% CI 1.09 to 1.52; p = 0.009) and increase in percentage of haemoglobin S (HbS) (AOR = 1.18, 95% CI 1.09 to 1.29; p < 0.001) were significant predictors of MM. Predictive margins showed that for a 16-year-old the average probability of having MM would be 51 percentage points higher than that of a two-year-old. Conclusion Increase in age, frequency of VOC, and an increase in the percentage of HbS were significant predictors of MM. These predictors maybe useful to clinicians in determining children who are at risk. Cite this article: Bone Joint Open 2020;1-6:175–181.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

et al. 2020

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Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

et al. 2020

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Testicular salvageability and its predictors among patients with testicular torsion in a resource limited setting; a multicentre longitudinal study

Mohamed,

Abraha,

Olasinde

et al. 2023

Preprint

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Introduction Testicular torsion refers to ischemia of the testicle due to twisting or rotation of the vessels supplying the testes. It is a urologic emergency requiring a high index of clinical suspicion and prompt surgical intervention with management aimed at avoiding testicular loss and resulting infertility. There is a paucity of data on this subject in low-income settings. This study was aimed at assessing testicular salvageability and its predictors among patients with testicular torsion at two tertiary African hospitals. Methods This was a hospital-based multicentre longitudinal study at two tertiary hospitals in western Uganda. Patients with acute scrotum were enrolled and assessed for testicular torsion. Those with torsion underwent surgery and salvageability was recorded as the primary outcome. Predictors were determined using backward binary logistic regression in SPSS version 22. Results During the study period, 232 patients with acute scrotum were enrolled. The mean age was 35.3 (SD=20.4) years. Forty-one (17.7%) patients had testicular torsion. Of the 41 diagnosed with torsion, only 16 (39.0%) had viable testis that were salvageable. Orchiectomy was done for 25 (61.0%). At multivariate analysis, a patient who presented after 48 hours from the onset of symptoms was 34.833 times more likely to have orchiectomy compared to one that presented within 12 hours [AOR=34.833, (95% CI=5.020-60.711), P<0.001]. Conclusion In this study, the testicular salvage rate was low. The only predictor of salvageability was the time from the onset of symptoms to presentation. All males should be sensitized about the clinical features of testicular torsion to ensure early presentation in to increase salvage rates.

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The prevalence and factors associated with musculoskeletal disorders, in patients with sickle cell anaemia, at Mulago National Referral Hospital, Uganda

Cited by 3 publications

References 19 publications

Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

Testicular salvageability and its predictors among patients with testicular torsion in a resource limited setting; a multicentre longitudinal study

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