The prevalence and economic burden of pain on middle-aged and elderly Chinese people: results from the China health and retirement longitudinal study

Qiu, Yudian; Li, Hu; Yang, Ziyi; Liu, Qiang; Wang, Kai; Li, Rujun; Xing, Dan; Hou, Yunfei; Lin, Jianhao

doi:10.1186/s12913-020-05461-6

Cited by 29 publications

(26 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The somatosensory dysfunction, especially itch and pain, among the aged population burdens public health (Berger et al, 2013;Blyth and Noguchi, 2017;Qiu et al, 2020). Our findings illuminated that spinal NPY deficiency induced the loss of mechanical itch gating in aged mice, which shed new light on therapeutic strategies for the treatment of senile pruritus.…”

Section: Discussionmentioning

confidence: 55%

Lack of Spinal Neuropeptide Y Is Involved in Mechanical Itch in Aged Mice

Cui

Cao

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Neuropeptide Y (NPY) signaling plays an essential role in gating the pruritic afferent information in the spinal cord. Recent studies revealed that the aging process down-regulated the expression of NPY in the central nervous system. We propose that the lack of spinal NPY may be involved in certain types of pruritus in the elderly population. This study was designed to investigate the role of NPY in aging-induced itch using the senile mouse model. The expression of NPY in the spinal dorsal horn was compared between young (2 months old) and aged (24 months old) mice. Western blotting and immunohistochemistry showed that the expression of NPY was significantly reduced in the spinal dorsal horn in aged mice. In addition, a neuronal maker of apoptosis, TUNEL, was detected in the NPY positive neurons only in the aged spinal cord. Behavioral assay indicated that light mechanical stimulus evoked significantly more scratching in the aged than in the young mice, whereas chemical-evoked itch and pain-related behaviors were not altered. Intrathecal injection of either NPY or LP-NPY, a NPY receptor 1 (NPY1R) agonist, significantly alleviated the mechanically evoked itch in aged mice without altering the responses to chemical pruritogens. Our study suggested that downregulation of spinal NPY in the aged mice might play a role in the higher incidence of the mechanically evoked itch than that in the young mice. Therapies targeting the NPY system might serve as a potential strategy for alleviating the pruritic symptoms among the elderly population.

show abstract

Section: Discussionmentioning

confidence: 55%

Lack of Spinal Neuropeptide Y Is Involved in Mechanical Itch in Aged Mice

Cui

Cao

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…The expenditure consisted of outpatient costs, inpatient costs, and self-medication costs, but not including non-medical costs (such as transportation, nursing, and accommodation costs) [ 33 ]. Self-medication costs referred to the expenses of self-seeking healthcare of hypertensive patients, mainly consisting of the cost of purchasing drugs at pharmacies [ 34 ]. The visit and cost of outpatient care and self-medication for hypertensive patients in a year were measured by the amount self-reported in the latest month, multiplied by 12.…”

Section: Methodsmentioning

confidence: 99%

Economic Burden of Depressive Symptoms Conditions among Middle-Aged and Elderly People with Hypertension in China

Zhao

Guo

et al. 2021

IJERPH

View full text Add to dashboard Cite

People with hypertension are more prone to incur depressive symptoms, while depressive symptoms have an obvious influence on the healthy functioning, treatment, and management of hypertensive patients. However, there have been limited studies on the association between depression and the economic burden of hypertension. We used data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) to estimate the additional annual direct and indirect economic burden of depressive symptoms among middle-aged and elderly hypertensive patients with a multivariable regression model. The depressive symptoms were associated with substantial additional direct and indirect economic burden. Compared with non-co-MHDS (non-co-morbid hypertension and depressive symptoms) patients, the direct economic burden of lower co-MHDS (co-morbid hypertension and depressive symptoms) patients and higher co-MHDS patients increased 1887.4 CNY and 5508.4 CNY, respectively. For indirect economic burden, the lower co-MHDS patients increased 331.2 CNY and the higher co-MHDS patients increased 636.8 CNY. Both direct and indirect economic burden were incremental with the aggravation of depressive symptoms. The results showed depressive symptoms increased total healthcare costs by increasing the utilization and expenditure of primary healthcare services. Depressive symptoms also led to economic loss of productivity, especially for agricultural workers. This study highlights the importance of mental healthcare for hypertensive patients.

show abstract

“…CHARLS was a longitudinal survey that aimed to be representative of the residents in mainland China aged 45 and older, with no upper age limit [30]. Multi-stage stratified probability-proportional-to-size sampling was used to conduct the survey, which randomly selected 150 counties/districts and 450 villages/resident committees, thereby covering 19,000 individuals living in 12,400 households [31] from 28 provinces (data from Hainan, Ningxia, and Tibet were missing), thus collecting a high-quality nationally representative sample [31][32][33][34]. The CHARLS database includes a series of topics, such as demographics, family structure/transfer, health status and functioning, health care and insurance, work, retirement and pension, income and consumption, and community-level information [33].…”

Section: Data Collectionmentioning

confidence: 99%

The Impacts of Regional Regulatory Policies on the Prevention and Control of Chronic Diseases in China: A Mediation Analysis

Huangfu

Shi

et al. 2021

Healthcare

View full text Add to dashboard Cite

Regional regulatory policies (RPs) are a major factor in the prevention and control of chronic diseases (PCCDs) through the implementation of various measures. This study aimed to explore the impacts of RPs on PCCDs, with a focus on the mediating roles of community service. The soundness of the regulatory mechanism (SORM) was used to measure the soundness of RPs based on 1095 policy documents (updated as of 2015). Coverage provided by community service institutions (CSIs) and community health centres (CHCs) was used to represent community service coverage derived from the China Statistical Yearbook (2015), while the number of chronic diseases (NCDs) was used to measure the effects of PCCDs based on data taken from the 2015 China Health and Retirement Longitudinal Study survey. To assess the relationship between SORM, NCDs and community service, a negative binomial regression model and mediation analysis with bootstrapping were conducted. Results revealed that there was a negative correlation between SORM and NCDs. CSIs had a major effect on the relationship between RPs and PCCDs, while CHCs had a partial mediating effect. RPs can effectively prevent and control chronic diseases. Increased effort should also be aimed at strengthening the roles of CSIs and CHCs.

show abstract

The prevalence and economic burden of pain on middle-aged and elderly Chinese people: results from the China health and retirement longitudinal study

Cited by 29 publications

References 44 publications

Lack of Spinal Neuropeptide Y Is Involved in Mechanical Itch in Aged Mice

Lack of Spinal Neuropeptide Y Is Involved in Mechanical Itch in Aged Mice

Economic Burden of Depressive Symptoms Conditions among Middle-Aged and Elderly People with Hypertension in China

The Impacts of Regional Regulatory Policies on the Prevention and Control of Chronic Diseases in China: A Mediation Analysis

Contact Info

Product

Resources

About