The Prevalence and Determinants of Nutritional Changes in Chronic Obstructive Pulmonary Disease

Braun, Sheldon R.; Keim, Nancy L.; Dixon, Russell M.; Clagnaz, Peter; Anderegg, A; Shrago, Earl

doi:10.1378/chest.86.4.558

Cited by 116 publications

(52 citation statements)

References 18 publications

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“…Stratification by KCO, which may discriminate between emphysematous and bronchitic patients [16,20], also appeared to be a discriminant for the prevalence of tissue depletion. The relationship between emphysema (based on measurements of diffusion capacity) and nutritional depletion has been reported by some authors, but disputed by others [4,5]. This controversy may be explained by the patient groups studied and the criteria to define emphysema [20].…”

Section: Discussionmentioning

confidence: 99%

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Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD

Engelen¹,

Schols²,

Baken³

et al. 1994

Eur Respir J

328

199

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Although increasing attention has been paid to nutritional aspects in chronic obstructive pulmonary disease (COPD), limited information is available regarding the prevalence and consequences of nutritional depletion in a random out-patient COPD population. We studied body composition in relation to respiratory and peripheral skeletal muscle function in 72 COPD patients (mean (SD) forced expiratory volume in one second (FEV1) 53 (15) % predicted), who came to the lung function laboratory for routine lung function measurements. Patients were characterized by the degree of body weight loss and fat-free mass depletion. According to this definition, 14% of the group suffered from both loss of body weight and depletion of fat-free mass, whereas 7% had one of these conditions. We found that tissue depletion was concomitant with lower values for respiratory and peripheral skeletal muscle strength (46.0 (27.2) vs 77.1 (29.8) kg), and a significantly lower transfer coefficient for carbon monoxide (KCO 64.9 (16.2) vs 81.9 (24.5) % pred). Stratification by KCO (< 60% vs > 80%) also revealed significantly lower values for fat-free mass and higher values for intrathoracic gas volumes, total lung capacity (TLC) and residual volume (RV) in the group with a KCO < 60% pred. Analysis of covariance, taking fat-free mass as covariate, indicated an independent contribution of KCO on maximal inspiratory mouth pressure (PImax) but not on peripheral skeletal muscle strength. It is concluded that a substantial number of COPD out-patients suffer from nutritional depletion, preferentially affecting peripheral skeletal muscle function.

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Section: Discussionmentioning

confidence: 99%

“…Depending on the patient population analysed, 20-70% of the COPD patients were found to be underweight [3][4][5][6][7][8]. All the reported studies were performed in selected populations, such as hospitalized patients, patients entering rehabilitation programmes or taking part in clinical trials.…”

mentioning

confidence: 99%

Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD

Engelen¹,

Schols²,

Baken³

et al. 1994

Eur Respir J

328

199

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“…Muscle mass loss is present in 18-36% of patients with COPD [228,229], while weight loss is evident in 17-35% of COPD patients depending on the population studied [228][229][230][231][232]. Muscle wasting can occur in patients with preserved weight [229].…”

Section: Skeletal Musclementioning

confidence: 99%

Ageing and the border between health and disease

2014

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Ageing is associated with a progressive degeneration of the tissues, which has a negative impact on the structure and function of vital organs and is among the most important known risk factors for most chronic diseases. Since the proportion of the world's population aged .60 years will double in the next four decades, this will be accompanied by an increased incidence of chronic age-related diseases that will place a huge burden on healthcare resources.There is increasing evidence that many chronic inflammatory diseases represent an acceleration of the ageing process. Chronic pulmonary diseases represents an important component of the increasingly prevalent multiple chronic debilitating diseases, which are a major cause of morbidity and mortality, particularly in the elderly. The lungs age and it has been suggested that chronic obstructive pulmonary disease (COPD) is a condition of accelerated lung ageing and that ageing may provide a mechanistic link between COPD and many of its extrapulmonary effects and comorbidities. In this article we will describe the physiological changes and mechanisms of ageing, with particular focus on the pulmonary effects of ageing and how these may be relevant to the development of COPD and its major extrapulmonary manifestations. @ERSpublications Premature ageing of the lung may constitute pathogenetic mechanisms contributing to COPD

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“…The incidence depends largely upon disease severity. As many as 25% of out-patients with COPD may be malnourished while almost 50% of patients admitted to hospital have evidence of malnutrition [1,2]. Critically ill COPD patients with acute respiratory failure (ARF) have a 60% incidence of malnutrition [3].…”

Section: Adverse Effects Of Malnutritionmentioning

confidence: 99%

Enteral nutrition in patients with respiratory disease

Pingleton¹

1996

Eur Respir J

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The Prevalence and Determinants of Nutritional Changes in Chronic Obstructive Pulmonary Disease

Cited by 116 publications

References 18 publications

Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD

Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD

Ageing and the border between health and disease

Enteral nutrition in patients with respiratory disease

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