The Prevalence and Correlation of Non-motor Symptoms in Adult Patients
                        with Idiopathic Focal or Segmental Dystonia

Novaretti, Nathália; Cunha, Ana Luiza Nunes; Bezerra, Torben C.; Pereira, Marcelo de Souza Fernandes; Oliveira, Daniel Sabino de; Brito, Manuelina Mariana Capellari Macruz; Pimentel, Angela Vieira; Brozinga, Tamara R.; Foss, Maria Paula; Tumas, Vítor

doi:10.5334/tohm.466

Cited by 53 publications

(53 citation statements)

References 36 publications

(47 reference statements)

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“…28 For comparison, patients with PD suffered from more severe apathy in both studies, 27,28 and apathy was linked with cognitive decline in PD. 22 A Brazilian study 29 Simultaneous screening for NMS by both approaches may increase the detection rate, however, at the cost of increased clinical effort.…”

Section: Ta B L E 5 Correlations Between the Domains Of Health-relatementioning

confidence: 99%

Prevalence of non‐motor symptoms and their association with quality of life in cervical dystonia

et al. 2020

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Despite the purely motor-related definition of cervical dystonia (CD), 1 evidence is growing that non-motor symptoms (NMS) are frequently present in CD patients and have a significant impact on the health-related quality of life (HRQoL) of these patients. 2 Depression and anxiety in particular were reported to be associated with CD and may be an intrinsic part of the CD phenotype. 3 Neuropsychiatric

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Section: Ta B L E 5 Correlations Between the Domains Of Health-relatementioning

confidence: 99%

Prevalence of non‐motor symptoms and their association with quality of life in cervical dystonia

et al. 2020

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“…Many people living with dystonia experience non-motor symptoms contributing to disability and reducing participation in daily activities (Smit et al 2017a;Stamelou et al 2012; Torres and Rosales 2017), leading to the development of non-motor symptom scales for dystonia (Smit et al 2017a;Klingelhoefer et al 2019). Non-motor symptoms featured strongly when people with CD were asked about their most burdensome symptoms (Smit et al 2017a) and the most prevalent experienced by people with idiopathic, isolated dystonia were pain, depression, anxiety, apathy, and impaired sleep (Smit et al 2017a;Novaretti et al 2019). Other non-motor symptoms such as fatigue, catastrophizing, sensorimotor disturbances, olfactory and visual problems have also been noted amongst others, and also impact negatively on quality of life (Zetterberg et al 2009).…”

Section: Non-motor Symptomsmentioning

confidence: 99%

Neurorehabilitation in dystonia: a holistic perspective

et al. 2020

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Rehabilitation for isolated forms of dystonia, such as cervical or focal hand dystonia, is usually targeted towards the affected body part and focuses on sensorimotor control and motor retraining of affected muscles. Recent evidence, has revealed people who live with dystonia experience a range of functional and non-motor deficits that reduce engagement in daily activities and health-related quality of life, which should be addressed with therapeutic interventions. These findings support the need for a holistic approach to the rehabilitation of dystonia, where assessment and treatments involve non-motor signs and symptoms, and not just the dystonic body part. Most studies have investigated Cervical Dystonia, and in this population, it is evident there is reduced postural control and walking speed, high fear of falling and actual falls, visual compensation for the impaired neck posture, and a myriad of non-motor symptoms including pain, fatigue, sleep disorders and anxiety and depression. In other populations of dystonia, there is also emerging evidence of falls and reduced vision-related quality of life, along with the inability to participate in physical activity due to worsening of dystonic symptoms during or after exercise. A holistic approach to dystonia would support the management of a wide range of symptoms and signs, that if properly addressed could meaningfully reduce disability and improve quality of life in people living with dystonia.

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“…disorder (35,36), other neuropsychiatric manifestations have been highlighted as features of dystonia, particularly in the past decade (10)(11)(12)(13)(14)(15). Furthermore, emerging evidence suggests that dystonia results from dysfunctional brain networks (37,38).…”

Section: Discussionmentioning

confidence: 99%

“…As the BG are connected to the limbic system, its dysfunction induces consequent non-motor neuropsychiatric symptoms in patients with dystonia (3)(4)(5). Indeed, recent studies have shown that such neuropsychiatric manifestations, including depression, anxiety, and obsessive-compulsive traits, are observed in patients with focal or segmental dystonia (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). The recent finding that patients with essential tremor (ET), a common motor characterized dysfunction of the cerebellum and consequent isolated tremor, also present with neuropsychiatric symptoms, may implicate psychiatric manifestations as part of the primary pathophysiology of movement disorders (3,(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor

2020

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Background: While idiopathic focal dystonia (IFD) and essential tremor (ET) have been considered pure movement disorders, they reportedly induce neuropsychiatric manifestations and may thus be more accurately described as network disorders. Methods: The present multi-center, cross-sectional, case-control study evaluated the severity of depression and anxiety with the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively; the frequency of neuropsychiatric disorders with the Korean-Mini International Neuropsychiatry Interview; and QoL with the Short-Form 36 (SF-36). Results: Seventy-four subjects participated in this study (IFD, 27; ET, 24; controls, 23). The BDI and BAI scores were higher in the IFD and ET groups than in the control group. Although the frequency of neuropsychiatric disorders diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Axis I was comparable among the groups, the prevalence of major depressive disorder tended to be high among patients with IFD. QoL was correlated with the severity of depression and anxiety across the groups. Conclusions: Depression and anxiety are more severe in patients with IFD and ET compared to healthy controls, while their severity is similar among patients with IFD and ET. Axis I major depressive disorder is relatively more prevalent in patients with IFD. Neuropsychiatric symptoms affect QoL regardless of the affected individual's condition, addressing neuropsychiatric symptoms in patients with movement disorders may be crucial to improving their QoL.

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The Prevalence and Correlation of Non-motor Symptoms in Adult Patients with Idiopathic Focal or Segmental Dystonia

Cited by 53 publications

References 36 publications

Prevalence of non‐motor symptoms and their association with quality of life in cervical dystonia

Prevalence of non‐motor symptoms and their association with quality of life in cervical dystonia

Neurorehabilitation in dystonia: a holistic perspective

Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor

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