The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy; A comparison with the fatigue experienced by healthy individuals

Irvine, D.; Vincent, Leslie; Graydon, Jane E.; Bubela, Natalie; Thompson, Leslee

doi:10.1097/00002820-199410000-00001

Cited by 361 publications

(243 citation statements)

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“…1,16,38 Estimates of cancer-related fatigue during initial treatment range from approximately 60% to 90%, 2,39-42 with the highest reported frequency in patients undergoing chemotherapy (80% to 96%) 40,43 compared with those treated with radiation (60% to 93%). 16,39,44 For example, in the study by Andrykowski et al, patients undergoing adjuvant chemotherapy were more than two-times as likely to report cancer-related fatigue during treatment compared with patients who were receiving adjuvant radiation therapy. 26 Bower has suggested that a key mechanism in the fatigue experienced during adjuvant radiation treatment may be the activation of proinflammatory cytokines.…”

Section: Fatigue During Treatmentmentioning

confidence: 99%

Breast Cancer and Fatigue

Bardwell

Ancoli‐Israel

2008

Sleep Medicine Clinics

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SynopsisFatigue is a common and disabling symptom in breast cancer patients and survivors. A rather nebulous concept, fatigue overlaps with sleepiness and depressed mood. In this chapter, we cover methods for assessing fatigue; describe the occurrence of fatigue before, during and after initial treatment; present possible underlying mechanisms of fatigue; and, enumerate approaches to its treatment. KeywordsFatigue; breast cancer; sleep; mood; fatigue assessment Fatigue is a common and frequently disabling symptom in cancer patients and cancer survivors. 1,2 Fatigue is also often a presenting symptom at cancer diagnosis. 3-5 Cancer fatigue differs from other manifestations of fatigue in that it is generally not alleviated by sleep or rest, is typically of greater duration and severity, is often associated with high levels of distress, and is disproportionate to the level of exertion. 6-11 Cancer-related fatigue often co-occurs with other troublesome symptoms such as pain, sleep disturbance, and depression. 12-14 Thus, the impact of cancer fatigue on health-related quality of life can be substantial, reducing the patient's engagement in work, personal and social activity. 2,15-17 Some studies have reported that fatigue in cancer patients has a greater negative impact on quality of life than all other symptoms, including nausea, pain and depression. 2,18 Treatment of cancer-related fatigue has been recently identified as a priority by the National Institutes of Health. 19 Specific to breast cancer, fatigue is reported by a substantial majority of patients during their initial treatment (surgery, radiation, and/or chemotherapy). In addition, although estimates vary widely, approximately 33% of individuals with breast cancer report persistent fatigue up to ten years into survivorship. 6,20,21 Fatigue is a rather nebulous symptom; hence, numerous definitions of this construct are found in the literature. 6,22 Complicating this situation is the fact that breast cancer patients and survivors commonly complain of both sleepiness and fatigue. 23 These terms are often used interchangeably, and both have been linked to decrements in various aspects of health-related Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. As is the case with pain, fatigue is a complaint that is almost always evaluated using self-report scales. 6,24 Therefore, by default, fatigue is ultimately defined by the instruments employed for its measurement. In the next section we provide an overview of several types of scales for assessing fatigue. NIH Public Access Assessment of FatigueThere are numerous self-r...

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Section: Fatigue During Treatmentmentioning

confidence: 99%

Breast Cancer and Fatigue

Bardwell

Ancoli‐Israel

2008

Sleep Medicine Clinics

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“…Depending on the patient sample and methodology employed, it is estimated that approximately 60 -96% of cancer patients who are undergoing cancer treatments experience fatigue (Cella, 1998). Fatigue is extremely common among cancer patients undergoing cytotoxic chemotherapy, radiation therapy, bone marrow transplant or treatment with biological response modifiers (Irvine et al, 1994;Dean et al, 1995;Hann et al, 1999;Jacobsen et al, 1999). For a significant number of patients, fatigue persists after treatment is completed.…”

Section: Prevalence Of Cancer-related Fatiguementioning

confidence: 99%

Fatigue and cancer: causes, prevalence and treatment approaches

2004

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Fatigue is the most prevalent cancer-related symptom and has a significant adverse impact on patients' functional ability and quality of life. Hypotheses regarding the aetiology of cancer-related fatigue are discussed, and clinical practice guidelines for the evaluation and management of oncology patients with fatigue are reviewed. Both nonpharmacologic and pharmacologic strategies for the management of fatigue are summarised.

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“…[9][10][11][12] In an early cross-sectional investigation, Wolcott et al 13 (1986) evaluated the physical symptomatology of young adult ABMT patients (n = 26), assessed at a mean of 42 months post-treatment. Approximately 25% reported frequent, ongoing physical symptoms including diarrhea, dry mouth and abdominal cramps, and one-third described having a high number of infections within the past year.…”

Section: Physical Symptomatology and Fatiguementioning

confidence: 99%

“…[9][10][11][15][16][17][18][19] For BMT patients, fatigue appears to be an especially significant and impairing problem. For example, a cross-sectional, descriptive study, conducted by Whedon et al 20 (1995), indicated that among 29 patients assessed, fatigue was the most frequently reported symptom, with 50% endorsing moderate to severe levels as many as 3 or more years after autologous transplant.…”

Section: Physical Symptomatology and Fatiguementioning

confidence: 99%

The psychosocial impact of bone marrow transplantation: a review of the literature

Neitzert

Ritvo

Dancey

et al. 1998

Bone Marrow Transplant

112

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Summary:Bone marrow transplant (BMT) is a procedure used for the treatment of a variety of cancers and malignant diseases. Recovery from this intensive process requires a long-term course, often accompanied by acute morbidity which includes various distressing physical symptoms. Recent literature has begun to explore the impact of this procedure on quality of life and psychosocial issues. While survivorship is often associated with a highly rated global quality of life, recovery from BMT is accompanied by several psychosocial difficulties which negatively impact patients. Fatigue is a common complaint, often hindering recipients for several years following their transplant. As well, reports of psychological distress, psychiatric symptoms, and/or mood disturbances such as anxiety or depression are not uncommon. Many patients also indicate interruption of sexual activity and increased sexual difficulty for several months following BMT. While some investigators have begun to examine hormone replacement therapy (HRT) as a treatment option for reducing sexual dysfunction, there is a general paucity of literature evaluating interventions for BMT survivors. This article reviews the literature examining various quality of life aspects including fatigue, psychosocial difficulties, and sexual functioning of patients during recovery from BMT. Limitations of past research are discussed and directions for future research suggested. Keywords: bone marrow transplantation; review; fatigue; sexual functioning; psychological distress Bone marrow transplantation (BMT) is an innovative procedure developed for treating malignant disease. The most common indications for BMT are Hodgkin's disease, nonHodgkin's lymphoma, leukemia, metastatic breast cancer, and its use is increased as treatment technology improves, particularly with respect to reduced morbidity and increased life expectancy. Two types of BMT are currently most Correspondence: CS Neitzert,

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The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy; A comparison with the fatigue experienced by healthy individuals

Cited by 361 publications

References 0 publications

Breast Cancer and Fatigue

Breast Cancer and Fatigue

Fatigue and cancer: causes, prevalence and treatment approaches

The psychosocial impact of bone marrow transplantation: a review of the literature

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