The prevalence and characteristics of coronary atherosclerosis in asymptomatic subjects classified as low risk based on traditional risk stratification algorithm: assessment with coronary CT angiography
Abstract:Although an asymptomatic population classified as low risk by the NCEP guideline has been regarded as a minimal risk group, the prevalence of atherosclerosis plaques and significant stenosis were not negligible. However, considering very low event rate for those patients, CCTA should not be performed in low-risk asymptomatic subjects, although CCTA might have the potential for identification of high-risk groups in the selected subjects regarded as a minimal-risk group by NCEP guideline.
“…In asymptomatic patients, however, the importance of the plaque subtype is uncertain. Recent studies based on an asymptomatic, Korean patient population undergoing health checkup showed no or very few clinical events in study subjects with noncalcified plaque and significant coronary stenosis (22,23). The clinical outcome of our study also showed a very low rate of revascularization and no cardiac death or myocardial infarction.…”
C-reactive protein is associated with noncalcified coronary arterial plaque, as seen at coronary CT angiography in asymptomatic patients after adjustment for traditional risk factors.
“…In asymptomatic patients, however, the importance of the plaque subtype is uncertain. Recent studies based on an asymptomatic, Korean patient population undergoing health checkup showed no or very few clinical events in study subjects with noncalcified plaque and significant coronary stenosis (22,23). The clinical outcome of our study also showed a very low rate of revascularization and no cardiac death or myocardial infarction.…”
C-reactive protein is associated with noncalcified coronary arterial plaque, as seen at coronary CT angiography in asymptomatic patients after adjustment for traditional risk factors.
“…Given the millions of these scans performed annually,28 the simple lobe-based visual grading system described may have great impact on healthcare expenditure. One caveat, though, is that lobe-based visual assessment of CT imaging findings is known to have lower inter-reader reliability than quantitative CT measurements in COPD 29. Despite this limitation, we favoured this method for various reasons.…”
Morphological correlates of COPD such as emphysema and airway thickening detected on CT scans obtained for other non-pulmonary indications are strong independent predictors of subsequent development of acute exacerbations of COPD resulting in hospitalisation or death.
“…CVD related to atherosclerosis, including ischemic heart disease and stroke, generally begins early in life but manifests clinically from middle age . Studies have shown that early life events including preterm birth are associated with increased cardiovascular mortality and with increased prevalence of HTN , impaired glucose metabolism , and adverse lipid profiles .…”
This study demonstrated that being born SGA and in particular preterm birth are associated with changes in retinal microvascular architecture. The prenatal and immediate postnatal environment may contribute to the mechanisms.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.