The Preterm Labor Syndrome

Romero, Roberto; Mazor, Moshe; Muñoz, H.; Gomez, Ricardo; Galasso, Maurizio; Sherer, David M.

doi:10.1111/j.1749-6632.1994.tb21771.x

Cited by 391 publications

(292 citation statements)

References 122 publications

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“…The increase of FW in the upright position may be caused by an interaction of uterine contractility, overdistension, downward pressure and mechanical or biochemical processes of the tissue and membranes at the internal os 5 .…”

Section: Discussionmentioning

confidence: 99%

“…During dilatation, digestion of denatured collagen leads to further loss of collagen and, consequently, of firmness 4 . Local or ascending intrauterine infections are thought to lead to activation of all the components of the preterm labor syndrome, whereby functional loss of cervical integrity is the common terminal pathway 5 . Conversely, cervical shortening and opening of the internal os may facilitate the ascension of microorganisms, injuries to the decidua-chorioamnion interface and, finally, membrane activation and amnionitis 5 .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of transvaginal sonography in recumbent and standing maternal positions to predict spontaneous preterm birth in singleton and twin pregnancies

Arabin

Roos

Kollen

et al. 2006

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of transvaginal sonography in recumbent and standing maternal positions to predict spontaneous preterm birth in singleton and twin pregnancies

Arabin

Roos

Kollen

et al. 2006

Ultrasound in Obstet & Gyne

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“…1 The chorioamniotic membranes undergo complex anatomical and biochemical events that lead to membrane rupture. 2,3 Morphological, biochemical and biophysical studies suggest that rupture of membranes results from the application of acute or chronic stress on localized areas of the membranes that are weaker.…”

Section: Introductionmentioning

confidence: 99%

Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature

Haddad

Tromp²,

Kuivaniemi³

et al. 2006

American Journal of Obstetrics and Gynecology

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195

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“…Among all premature births, about 30-40% are due to maternal infections, while among twin premature births the lack of space is the major cause of prematurity (Goldenberg et al, 2008;Romero et al, 2008).…”

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confidence: 99%

Hospitalization in Adolescence and Young Adulthood Among Twins and Singletons: A Swedish Cohort Study of Subjects Born Between 1973 and 1983

et al. 2013

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Children born with non-optimal birth characteristics -that is, are small for gestational age and/or preterm -have an increased risk for several long-term effects such as neurological sequelae and chronic disease. The purpose of this study was to examine whether twins exhibited a different outcome, compared with singletons, in terms of hospitalization during adolescence and early adulthood, and to what extent differences remain when considering the divergence in birth characteristics between singletons and twins. Persons born between 1973 and 1983 in Sweden and surviving until age 13 were included and followed until the end of 2006. Data on birth characteristics, parental socio-demographic factors, and hospitalizations were collected from national registers. Adjusting for parental socio-demographic factors, twins had a higher risk of being hospitalized than singletons (odds ratio, OR = 1.17, 95% confidence interval, CI = 1.10-1.25) and more often due to 'Congenital anomalies' (OR = 1.18, 95% CI = 1.06-1.28), 'Infections' (OR = 1.14; 95% CI = 1.08-1.20), 'External causes of illness' (OR = 1.10, 95% CI = 1.06-1.15), and 'Diseases of the nervous system' (OR = 1.18, 95% CI = 1.10-1.26). Stratifying for birth characteristics, this difference diminishes, and for some diagnoses non-optimal twins seem to do slightly better than non-optimal singletons. Thus, twins with non-optimal birth characteristics had a lower risk of hospitalization than non-optimal singletons on, for example, 'Congenital anomalies' and 'Diseases of the nervous system' (OR = 0.86, 95% CI = 0.77-0.96; OR = 0.88, 95% CI = 0.81-0.97, respectively) and Total (any) hospitalization (OR = 0.87, 95% CI = 0.83-0.92). Among those with optimal birth characteristics, twins had an increased hospitalization due to 'External causes of illness' (OR = 1.07, 95% CI = 1.02-1.13) compared with optimal singletons. Twins have higher hospitalization rates than singletons. In stratifying for birth characteristics, this difference diminishes, and for some diagnoses, non-optimal twins seem to do less poorly than non-optimal singletons.

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The Preterm Labor Syndrome

Cited by 391 publications

References 122 publications

Comparison of transvaginal sonography in recumbent and standing maternal positions to predict spontaneous preterm birth in singleton and twin pregnancies

Comparison of transvaginal sonography in recumbent and standing maternal positions to predict spontaneous preterm birth in singleton and twin pregnancies

Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature

Hospitalization in Adolescence and Young Adulthood Among Twins and Singletons: A Swedish Cohort Study of Subjects Born Between 1973 and 1983

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