The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes

Abstract

The preterm labor index was similar to the fetal fibronectin assay in its ability to predict preterm delivery.

Prediction of exact delivery time in patients with preterm labor and intact membranes at admission by amniotic fluid interleukin‐8 level and preterm labor index

“…On the other hand, a clinical marker for predicting preterm delivery was also reported. We reported on the PLI based on clinical findings (uterine contraction, genital bleeding and cervical dilation 17,18 ), and indicated that the likelihood of preterm delivery within one week in patients with a PLI score of ≥4 (50.7%) is significantly higher than that in patients with a PLI of ≤3 (10.3%) 6 . Another clinical marker, shorter cervical length in mid‐gestation, was reported by Iams et al .…”

“…Several biochemical markers associated with ascending inflammation (vaginitis, cervicitis and chorioamnionitis) and clinical markers such as the preterm labor index (PLI) 6 in preterm labor were reported to predict preterm delivery. In 1991, Lockwood et al .…”

“…Many studies have reported on risk factors such as clinical symptoms, short cervix, fFN in vaginal secretions or amniotic fluid cytokine levels for delivery within 48 h or 7 days, 6,19–21 which were especially important in short‐term tocolysis; however, studies have not been performed to evaluate the estimated delivery time. If the remaining gestational period could be predicted using an equation, perinatal management – such as the timing of maternal transport to a perinatal center with a NICU, the proper timing of steroid therapy and NICU bed control – could occur more efficiently and advantageously.…”

17OHP‐C in patients with spontaneous preterm labor and intact membranes: is there an effect according to the presence of intra‐amniotic inflammation?

“…Demographic and clinical data [maternal age, parity, history of PTB, pre-pregnancy body mass index, smoking during pregnancy, gestational weeks on admission, maternal body temperature, white blood cell (WBC) count, C-reactive protein, PLI, 20 At first, interval from admission to delivery (days) was compared between the 17OHP-C and no-treatment groups. Then, the interval from admission to delivery and perinatal factors was compared between the 17OHP-C and no-treatment groups in accordance with the severity of intra-amniotic inflammation (subgroups A, B, and C).…”

“…The timing of birth is strongly correlated with the severity of clinical symptoms [18][19][20] and intra-amniotic inflammation and/or infection [21][22][23] in PTL cases. Furthermore, it is possible to predict the timing of birth (interval from admission to delivery) using markers such as clinical symptoms and intra-amniotic inflammation.…”