The Pressure-Volume Relationship of the Normal Pulmonary Capillary Bed*

Daly, Walter J.; Giammona, Samuel T.; Ross, Jennifer Gunberg

doi:10.1172/jci105232

Cited by 18 publications

(4 citation statements)

References 24 publications

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“…The pulmonary veins account for most of the lung blood volume and the total compliance of the pulmonary circuit. The CHAPTER 28: RESPONSE TO STRESS: GRAVITY 1031 pulmonary capillaries are relatively noncompliant (72,86,360). Total pulmonary vascular compliance in the rabbit is -0.1 ml.mmHg-1.kg-1 body wt (86).…”

Section: Blood Volume and Distributionmentioning

confidence: 99%

Cardiovascular Adjustments to Gravitational Stress

Blomqvist

Stone

1983

Comprehensive Physiology

191

163

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Section: Blood Volume and Distributionmentioning

confidence: 99%

Cardiovascular Adjustments to Gravitational Stress

Blomqvist

Stone

1983

Comprehensive Physiology

191

163

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“…It is generally agreed that the size of the pulmonary capillary bed, as measured with the technic of Roughton and Forster (63), is directly dependent on the level of the transmural pulmonary vascular pressure (15,64,65). In particular, it has recently been reported that elevation of the transmural pressure by infusion of dextran and epinephrine to anesthetized dogs raises the pulmonary capillary blood volume (66).…”

Section: Fig 3 A) the Pressure-volume Relationship In The Pulmonarymentioning

confidence: 99%

Pulmonary vascular distensibility and lung compliance as modified by dextran infusion and subsequent atropine injection in normal subjects.

Giuntini¹,

Maseri²,

Bianchi³

1966

J. Clin. Invest.

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Little information is available on the pressurevolume relationship of the human pulmonary circulation. Observations have been almost exclusively confined to limited groups of cardiac patients (1-6) in whom coexistence of extravascular alterations, such as interstitial perivascular edema (7, 8), may hinder the interpretation of the results. On the other hand, extrapolation to man of animal studies on the pressure-volume characteristics of the whole pulmonary vascular bed or part of it is not always warranted because of species variation and wide experimental differences. Finally, the combined evaluation of pulmonary vascular resistance and transmural pressure may provide information on the distensibility of resistive vessels but does not allow deductions on the distensibility of the pulmonary circulation as a whole, since the distribution of volume does not parallel that of resistance.Previous reports have shown that the infusion of a plasma expander raised the pulmonary arterial and wedge pressures to the same extent (9); if the change in pressure was assumed to be practically uniform throughout the bed, such an infusion seemed to provide an opportunity to assess the compliance of the pulmonary vascular bed by determining the ratio of the change in volume to the change in pressure.The values of the distensibility of the pulmonary circulation obtained with dextran infusion during the first studies were thought to be exceedingly low. We then decided to test some drug that could enhance the distensibility of the pulmonary vascular bed. Atropine sulfate, which was

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“…This hypothesis is supported by the suggestion of DALY et al (1965) that the increasing rate of DL induced by an increase in capillary blood volume is decreased more upon pulmonary capillary dilation than upon pulmonary capillary recruitment.…”

Section: Discussionmentioning

confidence: 59%

Changes in Pulmonary Diffusing Capacity at Rest under Various Conditions of Posture and Temperature in Male and Female

Yasukouchi

1985

Journal of Anthropological Society of Nippon

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Changes in pulmonary diffusing capacity for carbon monoxide (DL), the diffusing capacity of the pulmonary capillary membrane (DM) and pulmonary capillary blood volume (Vc) at rest were examined in eight adult subjects of both sexes by the breath-holding method under different posture and temperature conditions ; i. e., in a supine position and a head-up position (45°) by the use of a tilting bed at three ambient temperatures of 15, 25 and 35*. Under all these conditions, DL was closely related to changes in Vc. Posture significantly affected DL and Vc in both males and females, the degree of difference due to each posture in males being similar to that in females. Although the influence of temperature on DL and Vc was significant in males, it was somewhat vague in females. The following causes of this phenomenon were suggested : the range of variation in the pulmonary arterial pressure due to thermal stimulation is narrow and the size of the lung is smaller in females than in males. The relation of DL to wide-spread changes in Vc in both sexes showed the form of a curve, probably because the increase in Vc mainly reflects the process of transformation of the pulmonary capillary from recruitment to dilation.

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The Pressure-Volume Relationship of the Normal Pulmonary Capillary Bed*

Cited by 18 publications

References 24 publications

Cardiovascular Adjustments to Gravitational Stress

Cardiovascular Adjustments to Gravitational Stress

Pulmonary vascular distensibility and lung compliance as modified by dextran infusion and subsequent atropine injection in normal subjects.

Changes in Pulmonary Diffusing Capacity at Rest under Various Conditions of Posture and Temperature in Male and Female

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