The Pressure-Volume Curve of the Cerebrospinal Fluid Space in Dogs

Löfgren, Jan; Essen, Claes von; Zwetnow, N. N.

doi:10.1111/j.1600-0404.1973.tb01330.x

Cited by 201 publications

(54 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three parts of the ICP-volume curve (Lofgren et al, 1973;Marmarou et al, 1991Marmarou et al, , 1975 were established (Fig. 3) by fitting a fourth-order polynomial trendline to the data points over the complete time course of injury observation for each animal.…”

Section: Resultsmentioning

confidence: 99%

Quantitative MRI Analysis of Brain Volume Changes due to Controlled Cortical Impact

Colgan

Cronin

Gobbo

et al. 2010

Journal of Neurotrauma

View full text Add to dashboard Cite

More than 85% of reported brain traumas are classified clinically as ''mild'' using the Glasgow Coma Scale (GCS); qualitative MRI findings are scarce and provide little correspondence to clinical symptoms. Our goal, therefore, was to establish in vivo sequelae of traumatic brain injury (TBI) following lower and higher levels of impact to the frontal lobe using quantitative MRI analysis and a mechanical model of penetrating impact injury. To investigate time-based morphological and physiological changes of living tissue requires a surrogate for the human central nervous system. The present model for TBI was a systematically varied and controlled cortical impact on deeply-anaesthetized Sprague-Dawley rats, that was designed to mimic different injury severities. Whole-brain MRI scans were performed on each rat prior to either a lower-or a higher-level of impact, and then at hourly intervals for 5 h post-impact. Both brain volume and specific anatomical structures were segmented from MR images for inter-subject comparisons post-registration. Animals subjected to lower and higher impact levels exhibited elevated intracranial pressure (ICP) in the low compensatory reserve (i.e., nearly exhausted), and terminal disturbance (i.e., exhausted) ranges, respectively. There was a statistically significant drop in cerebrospinal fluid (CSF) of 35% in the lower impacts, and 65% in the higher impacts, at 5 h compared to sham controls. There was a corresponding increase in corpus callosum volume starting at 1 h, of 60-110% and 30-40% following the lower-and higher-impact levels, respectively. A statistically significant change in the abnormal tissue from 2 h to 5 h was observed for both impact levels, with greater significance for higher impacts. Furthermore, a statistically significant difference between the lower impacts and the sham controls occurred at 3 h. These results are statistically substantiated by a fluctuation in the physical size of the corpus callosum, a decrease in the volume of CSF, and elevated levels of atrophy in the cerebral cortex.

show abstract

Section: Resultsmentioning

confidence: 99%

Quantitative MRI Analysis of Brain Volume Changes due to Controlled Cortical Impact

Colgan

Cronin

Gobbo

et al. 2010

Journal of Neurotrauma

View full text Add to dashboard Cite

show abstract

“…The pulse waves consist of multiple harmonics, with the fundamental harmonic amplitude of ISP at the heart rate frequency being proportional to the changes in the mean ISP value. This proportionality may suggest that the spinal pressurevolume relationship is exponential 2,17 -similar to the cranial compartment-and a characterization of both the elastance of the cerebrospinal space and the transmission of arterial pulsations to the CSF compartment. 4 The sRAP index, as an equivalent of RAP, denotes the degree of correlation between mean ISP and its amplitude in short periods of time and can indicate the working point in the exponential pressure-volume curve.…”

Section: Fig 4 Example Of a Long-term Recording Of Isp And Its Fundmentioning

confidence: 99%

Intraspinal pressure and spinal cord perfusion pressure after spinal cord injury: an observational study

Varsos

Werndle

Czosnyka

et al. 2015

SPI

View full text Add to dashboard Cite

OBJECT In contrast to intracranial pressure (ICP) in traumatic brain injury (TBI), intraspinal pressure (ISP) after traumatic spinal cord injury (TSCI) has not received the same attention in terms of waveform analysis. Based on a recently introduced technique for continuous monitoring of ISP, here the morphological characteristics of ISP are observationally described. It was hypothesized that the waveform analysis method used to assess ICP could be similarly applied to ISP. METHODS Data included continuous recordings of ISP and arterial blood pressure (ABP) in 18 patients with severe TSCI. RESULTS The morphology of the ISP pulse waveform resembled the ICP waveform shape and was composed of 3 peaks representing percussion, tidal, and dicrotic waves. Spectral analysis demonstrated the presence of slow, respiratory, and pulse waves at different frequencies. The pulse amplitude of ISP was proportional to the mean ISP, suggesting a similar exponential pressure-volume relationship as in the intracerebral space. The interaction between the slow waves of ISP and ABP is capable of characterizing the spinal autoregulatory capacity. CONCLUSIONS This preliminary observational study confirms morphological and spectral similarities between ISP in TSCI and ICP. Therefore, the known methods used for ICP waveform analysis could be transferred to ISP analysis and, upon verification, potentially used for monitoring TSCI patients.

show abstract

“…As a consequence, vasoconstriction produces a decrease in cerebral arterial blood volume and the opposite with vasodilatation. When the pressure-volume curve is steep (at higher ICP values with low intracranial compliance), changes in arterial blood volume produce significant changes in ICP in the same direction [4,5,21]. In this situation, AMP changes in the same direction with mean ICP changes (linear behavior) [4,5].…”

Section: Theoretical Background Of Paxmentioning

confidence: 89%

Pulsatile Intracranial Pressure and Cerebral Autoregulation After Traumatic Brain Injury

et al. 2011

View full text Add to dashboard Cite

show abstract

The Pressure-Volume Curve of the Cerebrospinal Fluid Space in Dogs

Cited by 201 publications

References 11 publications

Quantitative MRI Analysis of Brain Volume Changes due to Controlled Cortical Impact

Quantitative MRI Analysis of Brain Volume Changes due to Controlled Cortical Impact

Intraspinal pressure and spinal cord perfusion pressure after spinal cord injury: an observational study

Pulsatile Intracranial Pressure and Cerebral Autoregulation After Traumatic Brain Injury

Contact Info

Product

Resources

About