The cardio-respiratory effects of a thoracic epidural anaesthetic as is given for pain relief following upper abdominal surgery were examined in thirteen surgical patients studied in the immediate pre-operative period.following an overnight fast and without premedication.The focus of interest was on its effects on FRC and on gas exchange (measured as A-aD02 and OS/OT%), waich have not been previously reported. AlI subjects were given 10 ml/Kg glucose in saline I.V. during the pre-epidural periode Lidocaine 1.5% was used in aIl cases, plain lidocaine for the first eight and lidocaine with epinephrine 1/200,.000 in the other five subjects. This agent was given to achieve a sensory block to both pin-prick and ice up to T4. Neither FRC nor gas exchange showed any consistent changes following the epidural anaesthetic. These findings are in keeping with what was anticipated from a consideration of the basic physiology and pharmacology concerned and with a review of the pertinent literature. following an overnight fast and without premedication.The focus of interest was on its effects on FRC and on gas exChange (measured as A-aD02 and OS/OT%), which have not been previously reported. All subjects were given 10 ml/Kg glucose in saline I.V. during the ~re-epidural periode Lidocaine 1.5%was used in all cases, plain lidocaine for the first eight and lidocaine with epinephrine 1/200~OOO in the other five subjects. This agent was given to achieve a sensory block to both pin-prick and ice up to T4. Neither FRC nor gas exchange showed any consistent Changes following the epidural anaesthetic. These findings are in keeping with what was anticipated from a consideration of the basic physiology and pharmacology concerned and with a rev~ew of the pertinentliterature.w. MELEIKA~WAHBA' M.Sc. Exp. Red.