The present status of serodiagnosis and seroepidemiology of schistosomiasis

Maddison, Shirley E.

doi:10.1016/0732-8893(87)90026-5

Cited by 29 publications

(13 citation statements)

References 40 publications

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“…The use of serological screening methods in areas of low infection intensity after repeated rounds of chemotherapy has been advocated repeatedly (Maddison, 1987;Hoshino-Shimizu et al, 1992). Indeed, previous experiences from sero-epidemiological studies in areas of low endemicity highlight the advantages associated with the use of serological methods for surveillance, e.g.…”

Section: Discussionmentioning

confidence: 99%

Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China

et al. 2007

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Abstract. Bayesian spatial risk profiling holds promise to enhance our understanding of the epidemiology of parasitic diseases, and to target interventions in a cost-effective manner. Here, we present findings from a study using Bayesian variogram models to map and predict the seroprevalence of Schistosoma japonicum in Eryuan county, Yunnan province, China, including risk factor analysis. Questionnaire and serological data were obtained through a cross-sectional survey carried out in 35 randomly selected villages with 3,220 people enrolled. Remotely-sensed environmental data were derived from publicly available databases. Bivariate and non-spatial Bayesian multiple logistic regression models were used to identify associations between the local seroprevalence and demographic (i.e. age and sex), environmental (i.e. location of village, altitude, slope, land surface temperature and normalized difference vegetation index) and socio-economic factors. In the spatially-explicit Bayesian model, S. japonicum seroprevalence was significantly associated with sex, age and the location of the village. Males, those aged below 10 years and inhabitants of villages situated on steep slopes (inclination ≥20°) or on less precipitous slopes of >5°above 2,150 m were at lower risk of seroconversion than their respective counterparts. Our final prediction model revealed an elevated risk for seroconversion in the plains of the eastern parts of Eryuan county. In conclusion, the prediction map can be utilized for spatial targeting of schistosomiasis control interventions in Eryuan county. Moreover, S. japonicum seroprevalence studies might offer a convenient means to assess the infection pressure experienced by local communities, and to improve risk profiling in areas where the prevalence and infection intensities have come down following repeated rounds of praziquantel administration.

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Section: Discussionmentioning

confidence: 99%

Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China

et al. 2007

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“…Antibody-detecting assays with the proper antigens are highly specific and sensitive (Maddison et al 1985;Maddison 1987;Tsang et al 1983cTsang et al , 1984.…”

Section: Introductionmentioning

confidence: 98%

“…In Egypt, schistosomiasis, caused by S.mansoni and S.haematobium, is the most important endemic disease (Abdel-Wahab 1982;Abdel-Wahab and Mahmoud 1987) Estimation of the intensity of schistosomal infection is currently based on quantitative egg counts, which can be highly variable (Deelder et al 1989) and may depend on immune-response status of the host (Doenhoff et al 1978). Therefore, patient management, based solely on the presence of ova, is overly conservative and may result in patients with low egg count being undiagnosed and able to continue to transmit the disease (Maddison 1987).…”

Section: Introductionmentioning

confidence: 99%

Improving the detection limit of quantitative diagnosis of anti-S. haematobium antibodies using Falcon Assay Screening Test (FAST) ELISA by developing a new standard curve

Abdelfattah¹,

Al-Sherbiny

Osman

et al. 2010

Parasitol Res

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Immunodiagnosis of schistosomiasis are currently based on parasitological examinations of stool and urine for egg detection, which is laborious and lacks sensitivity. There are many assays that detect the anti-schistosomal antibodies in patient sera. One of these assays is the Falcon assay screening test (FAST) ELISA that uses adult worm microsomal antigen for Schistosoma haematobium and Schistosoma mansoni, HAMA, MAMA antigen, respectively. This assay depends on quantitative detection of anti-schistosome antibodies, using a standard curve, but the detection limit of FAST-HAMA assay is low due to the small range of the standard curve. In our study, a new wide range (0-80 μl/μl) of standard curve for FAST-HAMA assay was constructed, and the cut-off value of the assay, using the new curve, was determined to be 1.2 units/μl. Screening of 41 S. haematobium-infected sera with FAST-HAMA, using the new constructed curve, showed a sensitivity of 95%. The purity of HAMA antigen and highly specific Abs for S. haematobium lends the FAST-HAMA with the new constructed wide range standard curve as a diagnostic assay with high detection limit for S. haematobium infection.

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“…Also, it is not possible to distinguish previous exposure from current infections or reinfections. 45,[91][92][93] A PCR method has been developed as a highly sensitive and specific technique to detect Schistosoma sp. DNA.…”

Section: Diagnosismentioning

confidence: 99%

Schistosomiasis - An Unusual Cause of Ureteral Obstruction: A Case History and Perspective

Neal¹

2004

Clinical Medicine & Research

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The present status of serodiagnosis and seroepidemiology of schistosomiasis

Cited by 29 publications

References 40 publications

Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China

Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China

Improving the detection limit of quantitative diagnosis of anti-S. haematobium antibodies using Falcon Assay Screening Test (FAST) ELISA by developing a new standard curve

Schistosomiasis - An Unusual Cause of Ureteral Obstruction: A Case History and Perspective

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