The Present State of Liver Transplantation and the Future Prospects for Intestinal Transplantation

Starzl, Thomas E.

doi:10.3109/08820138909112267

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…The initial limiting factor in survival posttransplantation was the availability of suitable immunosuppressive agents (Starzl 2000 ;Starzl and Barker 2009 ;Starzl et al 1987 ). The current use of FK506 has signifi cantly improved graft survival overall and decreased associated complications due to cyclosporin, especially renal disease (Todo et al 1991 ;Starzl 1989 ;Fung et al 1996 ). The cyclosporin era continued for over 20 years, and it was not until the 1990s that tacrolimus (FK506) was introduced (Randhawa et al 1992 ;Demetris et al 1987 ;Fung et al 1987 ).…”

Section: Pediatric Liver Transplant Pathologymentioning

confidence: 99%

Pathology of Pediatric Gastrointestinal and Liver Disease

2014

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Section: Pediatric Liver Transplant Pathologymentioning

confidence: 99%

Pathology of Pediatric Gastrointestinal and Liver Disease

2014

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“…Historically, one of the early animal models for liver transplantation was a canine auxiliary transplant done by Welch in 1955. Experimental orthotopic liver transplantation, however, was first described by Cannon in 1956 in an article published in Transplantation Bulletin [ 1 ]. Moore and Starzl simultaneously performed whole organ liver transplantation in dogs, utilizing two important prerequisites.…”

Section: Introductionmentioning

confidence: 99%

Sheep as a Model for Liver Transplantation

Al-Sebayel¹,

Elsheikh²,

Almohanna³

et al. 2023

Cureus

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Objective: Experimental animal liver transplantation is the initial step, before the application of the procedure on humans. Canine and swine transplantation were used to perfect the technical aspects of the procedure. Small animals such as rats were mainly utilized to study the metabolic and immunological aspects of liver transplantation. In this paper, we describe our experience with attempting liver transplantation in a sheep animal model. Material and method: The animal model used for both donor and recipient was outbred male weanling sheep of Naimi strain ( Ovis aries, Awassi). They weigh between 25 and 35 kg. They were put under general anesthesia. Harvested livers were kept in cold storage. Recipients underwent hepatectomy, after construction of an active portal systemic bypass using a Medtronic pump. The implantation was done with caval replacement and direct portal anastomosis. The hepatic artery with its attachments to the aortal was anastomosed directly to the recipient aorta. Result: Twelve pairs (24 sheep) were utilized for donor and recipient surgery. Donor surgery was completed successfully in all 12 cases. Recipient surgery was not completed in three cases, when animals were lost in the implantation phase, before reperfusion mainly due to uncontrolled bleeding, resulting in hemodynamic instability. We also lost five recipients immediately after reperfusion, mainly due to post-perfusion bleeding and hemodynamic instability. Four recipients stayed alive after the implantation. Conclusion: We demonstrated the feasibility of using sheep as an animal model for liver transplantation. We described the similarities of sheep liver to that of humans, as well as the technical difficulties. This model is suitable in situations where other well-established models are not available for cultural or religious reasons. Further refinement in the technical aspects will be needed, as well as investigation of the biochemical outcome and long-term survival.

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Liver Transplantation: Historical Perspective

Kang

2016

Anesthesia and Perioperative Care for Organ Transplantation

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The Present State of Liver Transplantation and the Future Prospects for Intestinal Transplantation

Cited by 9 publications

References 17 publications

Pathology of Pediatric Gastrointestinal and Liver Disease

Pathology of Pediatric Gastrointestinal and Liver Disease

Sheep as a Model for Liver Transplantation

Liver Transplantation: Historical Perspective

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