The present and future for acyclovir

Brigden, D.; Keeney, Ronald E.; King, Dannie H.

doi:10.1093/jac/12.suppl_b.195

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Pharmacokinetics1

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“…4 Orally administered acyclovir is poorly absorbed from the gastrointestinal tract. 7 The peak plasma concentration is reached within 1.5 to 2 hours of administration; with continued administration, steady-state is reached within 1 to 2 days. 8 The bioavailability of orally administered acyclovir is about 20%.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Acyclovir

Zabrosky¹,

Milkovich²

1986

Infect. Control

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In recent years there have been great advances made in antiviral therapy. One of the most promising of the new agents to be introduced is acyclovir. This antiviral, which selectively inhibits the replication of particular DNA viruses, is being used clinically in the treatment and prevention of viral infections caused by several of the herpes viruses. Though not a cure, acyclovir can be effective for the management of symptoms associated with these infections. Since acyclovir acts only on replicating viral DNA, the drug has no effect on the latent virus which establishes itself in neural tissue. This makes eradication of the virus very difficult.

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Section: Pharmacokineticsmentioning

confidence: 99%