The Presence of Vessel Co-option Determines Overall Survival in Patients with Colorectal Cancer Liver Metastasis

Krzywon, Lucyna; Zlotnik, Oran; Lazaris, Anthoula; Nawawi, Abrar; Balvardi, Saba; Kalil, J.; Masi, A.; Metrakos, Peter

doi:10.1016/j.hpb.2022.05.185

Cited by 1 publication

(2 citation statements)

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“…The location of the tumor was de ned according to the anatomopathological report, being dichotomized into right and left sides, when the tumor was located proximally or distally to the splenic angle, respectively [19]. The degree of differentiation was established according to the World Health Organization (WHO) Classi cation as well-differentiated (G1) to undifferentiated (G4) [20].…”

Section: Histological Studymentioning

confidence: 99%

“…A new easily evaluated prognostic factor was recently identi ed -the histological growth pattern of CRC liver metastases (CRCLM), and some studies demonstrate that different growth patterns in uence tumor progression/response [17,18]. The different growth patterns represent the complexity of the tumor/host interactions, translating probable responses of an angiogenic [19] or in ammatory nature, but they can also be a consequence of the biological characteristics of the primary CRC. However, the main disadvantage is that it is only possible to know the growth pattern of CRCLM after resection, that is, after surgery [20].…”

Section: Introductionmentioning

confidence: 99%

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Predicting colorectal cancer liver metastases histological growth patterns: inflammation on the primary tumor is associated with desmoplastic growth pattern

Abrantes,

Oliveira,

Oliveiros

et al. 2024

Preprint

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Background: More than 50% of patients diagnosed with colorectal cancer (CRC) will develop liver metastases (CRCLM), which is the main cause of death for more than 60% of these patients. The aim of this study was to correlate the clinical and pathological characteristics of the primary CRC and CRCLM, with emphasis in predicting the histological growth pattern of the CRCLM. Methods: Cohort of seventy-three patients with CRC. Analysis of clinical data and blinded pathological review was performed related with primary tumor and CRCLM features. The analysis was performed in SPSS (version 27) with a significance level of 5%. Results: A statistically significant association was found between tumor size and metastasis growth pattern (p=0.002), with larger tumors giving rise to metastases with a non-desmoplastic growth pattern. Lymphovascular invasion (LVI) was associated with metachronous CRCLM (p=0.043). In the absence of LVI, the time required for CRCLM to appear was significantly longer (p=0.011). The number of metastases was significantly higher (p=0.049) in tumors without LVI when compared to tumors with LVI. There was a statistically significant association between CRC high-grade inflammation and the desmoplastic metastases growth pattern of the CRCLM (p= 0.017). Conclusion: The possibility of predicting the CRCLM histological growth pattern resorting to primary CRC characteristics would be useful for proper patient selection for surgery and adapting biological therapies.

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Section: Histological Studymentioning

confidence: 99%