The presence of tri-allelic TPOX genotypes in Dominican Population

Díaz, Vilma; Rivas, Patria; Carracedo, Ángel

doi:10.1016/j.fsigss.2009.09.021

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…This is possible through the visualization of the amplified DNA fragments that vary in size depending on the carried genotype (Diaz V et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

TPOX Triallelic Genotype: An Interesting Pattern to Be Noted in Bone Marrow Transplantation Monitoring

HoteitRouba

Abdul²,

AntarAhmad³

et al. 2015

Genetic Testing and Molecular Biomarkers

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“…This is possible through the visualization of the amplified DNA fragments that vary in size depending on the carried genotype (Diaz V et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

TPOX Triallelic Genotype: An Interesting Pattern to Be Noted in Bone Marrow Transplantation Monitoring

HoteitRouba

Abdul²,

AntarAhmad³

et al. 2015

Genetic Testing and Molecular Biomarkers

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“…In the present study TPOX showed heterozygosity values higher than those for CSF1PO (Table 5). Tri allelic pattern frequently observed for TPOX (Butler, 2005, Lane, 2008Diaz, Rivas, & Carracedo, 2009) was not observed across the five subpopulations of Pakistan. Results emphasized that the STR loci should be investigated extensively for their efficiency as human identification markers across the populations and subpopulations of the Indian subcontinent.…”

Section: Discussionmentioning

confidence: 76%

Inferring Human Phylogenies Using Three CODIS STR Markers (CSF1PO, TPOX and TH01)

Akram¹

2014

IJB

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Over the past several decades polymorphic genetic loci have been discussed for their utility in human phylogenetic inferences. Short Tandem Repeat (STR) loci have shown promising results for this purpose. Unfortunately, allele frequency data of polymorphic loci are largely confined to few populations. Therefore, the number of shared loci declines as the number of population increases. We hypothesize that even a smaller number of STR loci can be used efficiently for phylogenetic purposes if an appropriate theoretical and statistical strategy is employed. This strategy provides a feasible and cost effective method to choose appropriate STR loci for phylogenetic studies. For this purpose, an empirical study was conducted using allele frequency data of three STR loci CSF1PO, TPOX, and TH01 across 98 human populations from the literature (references are available at http://dnaa.bravehost.com/ index.html and http://www.cstl.nist.gov/strbase/population/Omnipop). The choice of markers was based on locus polymorphism, high heterozygosity, low mutation rate, less artifacts and independence between the loci. Three methods were used to measure genetic distances between the populations; Cavalli Sforza's chord distance (D C ), Nei's genetic (D A ) and Nei's standard genetic distances (D ST ). Coefficient of variation (CV) was calculated across hundred (100) datasets obtained by re-sampling of the original dataset for each of the genetic distance methods. CV was in order of D ST >D A >D C . Therefore, a consensus tree based on D C was constructed using Neighbour Joining (NJ), Unweighted Pair Group Method with Arithmatic mean (UPGMA) and Maximum Likelihood (ML) methods. NJ and UPGMA methods got more statistical support that is higher bootstrap values than ML (NJ> UPGMA> ML). Validation study was performed using (A) Principal Component Analysis (B) Comparison with trees reported for other molecular markers (C) STR genotyping of five Pakistani subpopulations. Results strongly supported our hypothesis that the three STR markers CSF1PO, TPOX, and TH01 are successful in delineating ethnic, geographic and linguistic differentiation between the populations.

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“…(3) Frequency of biological 'artifacts' for the three STR loci is low (Appendix C). The tri-allelic pattern of TPOX was mostly observed for the populations of Africa (Lane, 2008;Diaz et al, 2009). The microvariant allele of TH01 locus, 9.3, is common among Western Eurasian populations.…”

Section: Choice Of Str Markersmentioning

confidence: 96%