The Presence of the Intrinsic Factor of Castle in the Gastric Juice of Patients With Pernicious Anemia

Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia. Vii. Resemblances Between the Proteolytic Activity of Normal Human Gastric Juice on Casein in Neutral Solution and the Activity of the Intrinsic Factor 1

“…Likewise, boiling for 5 minutes destroyed the in vitro activity of gastric juice on casein, as shown in Table III Since the administration of beef muscle alone to patients with addisonian pernicious anemia does not produce hematopoietic effects, it has been inferred that intrinsic factor is diminished (7,16) or is absent (1) in the gastric secretion in addisonian pernicious anemia. From each of two patients with pernicious anemia 50 ml.…”

Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia. Viii. Further Studies of the Proteolytic Activity of Normal Human Gastric Juice in Vitro; And the Limitations of the Method in Pernicious Anemia 1

“…in an hour, was unusually great for the average patient with pernicious anemia (see Table IV (10). When, however, presumably larger amounts (7,11) (12) has demonstrated that when 150 ml. of gastric contents derived from pernicious anemia patients were given daily with 200 grams of beef muscle, moderate effects on blood production in another patient with pernicious anemia were observed.…”

Yeast as an Extrinsic Factor in Relation to Pernicious Anemia

“…Previous work (5,6) has demonstrated that the intrinsic factor deficiency in pernicious anemia is quantitative rather than qualitative and that the gastric juice of patients with pernicious anemia, even in relapse, contains intrinsic factor, but in such small amounts that it will not prevent anemia in the patient. Thus, if an excess of extrinsic factor is supplied to such patients, it is conceivable that enough hematopoietic substance will be formed in zivo to prevent anemia or, at least, reduce the requirement for preformed hematopoietic substance.…”