The Presence of Cytokines and Growth Factors in Hydrosalpingeal Fluid

Strandell, Annika; Thorburn, Jane; Wallin, Ann

doi:10.1023/b:jarg.0000042009.93520.15

Cited by 34 publications

(22 citation statements)

References 30 publications

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“…Uterine macrophages and natural killer (NK) cells are a primary source of TNF in the reproductive tract, as well as oviductal epithelial cells of mice and women Bedaiwy et al 2005;Strandell et al 2004). TNF stimulates translocation of the nuclear factor kappa B (NFκB) transcription factors to the nucleus, subsequently triggering transcription of various inflammatory mediators such as IL6 and IL1α (Iwamoto and Konicek 1997;Malinin et al 1997).…”

Section: Tumour Necrosis Factor Alpha (Tnf)mentioning

confidence: 99%

Female Tract Cytokines and Developmental Programming in Embryos

Robertson

Chin

Schjenken

et al. 2015

Advances in Experimental Medicine and Biology

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In the physiological situation, cytokines are pivotal mediators of communication between the maternal tract and the embryo. Compelling evidence shows that cytokines emanating from the oviduct and uterus confer a sophisticated mechanism for 'fine-tuning' of embryo development, influencing a range of cellular events from cell survival and metabolism, through division and differentiation, and potentially exerting long-term impact through epigenetic remodelling. The balance between survival agents, including GM-CSF, CSF1, LIF, HB-EGF and IGFII, against apoptosis-inducing factors such as TNFα, TRAIL and IFNg, influence the course of preimplantation development, causing embryos to develop normally, adapt to varying maternal environments, or in some cases to arrest and undergo demise. Maternal cytokine-mediated pathways help mediate the biological effects of embryo programming, embryo plasticity and adaptation, and maternal tract quality control. Thus maternal cytokines exert influence not only on fertility and pregnancy progression but on the developmental trajectory and health of offspring. Defining a clear understanding of the biology of cytokine networks influencing the embryo is essential to support optimal outcomes in natural and assisted conception.

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Section: Tumour Necrosis Factor Alpha (Tnf)mentioning

confidence: 99%

Female Tract Cytokines and Developmental Programming in Embryos

Robertson

Chin

Schjenken

et al. 2015

Advances in Experimental Medicine and Biology

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“…Each of these are elevated in ovarian carcinomas (Strandell et al 2004). It is well established that a combination of tubal ligation and hysterectomy is protective against ovarian cancer (Green et al 1997, Seidman et al 2002.…”

Section: Inflammation and The Ovarian Surface Epitheliummentioning

confidence: 99%

The emerging role of CXC chemokines in epithelial ovarian cancer

et al. 2012

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In recent years, chemokines have generated intense investigations due to their involvement in both physiological and pathological processes of inflammation, particularly in ovarian biology. The physiological process of ovulation in the normal ovary involves various chemokines that mediate the healing of the ruptured endometrium. It is now being reported that many of these chemokines are also associated with the cancer of the ovary. Chronic inflammation underlies the progression of ovarian cancer; therefore, it raises the possibility that chemokines are involved in the inflammatory process and mediate immune responses that may favour or inhibit tumour progression. Ovarian cancer is a gynaecological cancer responsible for highest rate of mortality in women. Although there have been several investigations and advances in surgery and chemotherapy, the survival rate for this disease remains low. This is mainly because of a lack of specific symptoms and biomarkers for detection. In this review, we have discussed the emerging role of the CXC chemokines in epithelial ovarian cancer (EOC). The CXC group of chemokines is gaining importance in the field of ovarian cancer for being angiostatic and angiogenic in function. While there have been several studies on the angiogenesis function, emerging research shows that ELR K CXC chemokines, CXCL9 and CXCL10, are angiostatic. Importantly, the angiostatic chemokines can inhibit the progression of EOC. Given that there are currently no biomarkers or specific therapeutic targets for the disease, these chemokines are emerging as promising targets for therapy.

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“…The development of the embryo before implantation is regulated by many embryotrophic molecules, growth factors, and cytokines produced in the lumen of the oviduct by maternal cells and the embryo itself. 24,25 Systemic infection or inflammation may disturb this network and induce infertility, even if the reproductive tract is not itself infected. T. cruzi is known to possess strong proinflammatory activities, 26 and the acute infection is associated with a strong inflammatory response, with systemic production of TNF-␣ 15 and interferon-␥ (IFN-␥).…”

Section: Discussionmentioning

confidence: 99%

Infertility in Murine Acute Trypanosoma cruzi Infection Is Associated with Inhibition of Pre-Implantation Embryo Development

Boufker

Alexandre

Carlier

et al. 2006

The American Journal of Pathology

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We previously showed that Trypanosoma cruzi acute infection induced infertility in a great proportion of female mice, which resulted from a defect taking place before implantation. In this study, we have analyzed every step of reproduction from mating to implantation to identify the most sensitive event. Our results show that mating, ovulation, fertilization, and first division of the zygote of infected mice take place normally compared with uninfected mice, indicating that the defect occurred after the two-cell stage. In vivo development of two-cell embryos to the blastocyst stage was indeed dramatically delayed; some embryos even arrested their development before having reached the eight-cell stage while others degenerated. The effect was less pronounced when embryos were allowed to develop in vitro, indicating that the infectious context of the mother plays a role in maintaining growth retardation. The delay of embryonic development was associated with insufficient divisions of the blastomeres and led to abnormal blastocyst outgrowth that may explain implantation failure. Inhibition of cell division was correlated with the maternal parasitemia. This work clearly shows that T. cruzi infection dramatically impedes embryonic development, offering a model for further in vivo studies of embryotrophic factors produced by the oviduct of infected females.

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The Presence of Cytokines and Growth Factors in Hydrosalpingeal Fluid

Cited by 34 publications

References 30 publications

Female Tract Cytokines and Developmental Programming in Embryos

Female Tract Cytokines and Developmental Programming in Embryos

The emerging role of CXC chemokines in epithelial ovarian cancer

Infertility in Murine Acute Trypanosoma cruzi Infection Is Associated with Inhibition of Pre-Implantation Embryo Development

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