The Presence of a Virulence Factor in M Protein Extracts of Group A Streptococci: 1. The Enhancement of Virulence of Homologous Streptococci by these Extracts

Krasner, Robert I.; Young, G.; Heitmann, R.

doi:10.1093/infdis/114.5.401

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that streptococcal strains virulent for mice and resistant to phagocytosis generally contain large amounts of M protein located at the surface of the bacterial cell [13]. In such strains M protein may be the chief inhibitor against phagocytosis.…”

Section: Discussionmentioning

confidence: 99%

The Role of Complement in Immune Phagocytosis of Group A Streptococci by Mouse Peritoneal Phagocytic Cells

Saito

Horikawa

Kondo

1973

Japanese Journal of Microbiology

View full text Add to dashboard Cite

The role of complement in ingestion of nonencapsulated virulent group A streptococci by mouse peritoneal phagocytic cells was studied in vitro in the presence of type‐specific IgG or IgM anti‐M antibody. Type‐specific IgG anti‐M antibody significantly enhanced the phagocytosis, whereas IgM antibody was less effective in opsonization of the virulent group A streptococci. The extent of phagocytosis of streptococci sensitized with IgG or IgM anti‐M antibody was not influenced by the presence of complement. These results suggested that complement was not an essential factor for efficient phagocytosis of virulent group A streptococci.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of Complement in Immune Phagocytosis of Group A Streptococci by Mouse Peritoneal Phagocytic Cells

Saito

Horikawa

Kondo

1973

Japanese Journal of Microbiology

View full text Add to dashboard Cite

show abstract

“…The hemolytic moiety can be transferred from one carrier to the other ( 1343). A factor enhancing virulence of streptococci was demonstrated in M-contaiiiing extracts (681 ). A hemagglutination test may be inore sensitive than the classic bactericidal test in detecting anti-M antih d i c s and rnay be specific if suitable absorptions arc carried out (1012).…”

Section: Biology Of Group a Streptococcimentioning

confidence: 99%

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

1966

Arthritis & Rheumatism

View full text Add to dashboard Cite

“…Conversely, the cell wall or outer envelope would be a most advantageous location for bacterial factors that could thwart host defense systems. Antiphagocytic materials are often located on or incorporated in the outer envelopes of bacteria (5,12,15). The chemical composition of some bacteria may make them resistant to killing by normal phagocytes (6,11), and some pathogens may contain substances in or on their outer envelopes that inhibit phagosome-lysosome fusion (7,11).…”

mentioning

confidence: 99%

Listeria monocytogenes Cell Walls Induce Decreased Resistance to Infection

Baker

Campbell

1978

Infect Immun

View full text Add to dashboard Cite

A significant decrease in murine resistance to Listeria monocytogenes was induced by using crude Listeria cell wall fraction (LCWF) and purified Listeria cell walls (PF). When equal amounts of these materials were injected, PF was more effective than LCWF in decreasing resistance. The PF effect was dose dependent when measured either as a decrease in 50% lethal dose of the Listeria challenge or as a decrease in survival time of the infected mice. PF apparently does not act directly on the Listeria since it (i) did not cause a change in in vitro growth of Listeria and (ii) did not increase the virulence of Listeria passaged in vivo or in vitro. The greatest decrease in resistance was observed when both PF and the Listeria challenge were injected intraperitoneally, which may suggest a localized effect. A decrease in resistance was seen when PF was given as early as 3 days before challenge. There was little or no decrease in resistance when PF was given 2 days after the Listeria challenge. Mice previously immunized with live Listeria were immune to Listeria challenge. However, after PF injection the immune mice showed a decreased resistance which was of the same order of magnitude as that seen in unimmunized mice. The effect of PF seems to be at least partially nonspecific, since a decrease in resistance to Salmonella typhimurium could also be demonstrated in PF-treated mice. Phagocytosis of Listeria both in vivo and in vitro did not appear to be inhibited by PF, although the ability of PF-treated mice to kill Listeria in the peritoneal cavity was inhibited.

show abstract

The Presence of a Virulence Factor in M Protein Extracts of Group A Streptococci: 1. The Enhancement of Virulence of Homologous Streptococci by these Extracts

Cited by 5 publications

References 0 publications

The Role of Complement in Immune Phagocytosis of Group A Streptococci by Mouse Peritoneal Phagocytic Cells

The Role of Complement in Immune Phagocytosis of Group A Streptococci by Mouse Peritoneal Phagocytic Cells

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

Listeria monocytogenes Cell Walls Induce Decreased Resistance to Infection

Contact Info

Product

Resources

About