The prescription patterns of traditional Chinese medicine for women with polycystic ovary syndrome in Taiwan

Lin, Mei-Jiun; Chen, Hsiao‐Wei; Liu, Pi-Hua; Cheng, Wei-Jen; Kuo, Shun-Li; Kao, Ming-Chen

doi:10.1097/md.0000000000015890

Cited by 21 publications

(18 citation statements)

References 22 publications

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“…Herba Leonuri, also named Chinese Motherwort, has been widely used for the treatment of dysfunctional uterine bleeding, dysmenorrhea, polycystic ovary syndrome and other gynecological diseases for hundreds of years ( Lin et al, 2017 ; Lin et al, 2019 ). It has been reported that chemical components, including alkaloids, phenolic acids, flavonoids, as well as volatile oil and tannins, have been isolated and identified in Herba Leonuri (Wang et al, 2013; Wojtyniak et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Chemical Fingerprint Analysis and Ultra-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Study of the Protective Effect of Buxue Yimu Granule in Medical-Induced Incomplete Abortion Rats

Zhang

Chen

et al. 2020

Front. Pharmacol.

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Medical abortion is a common method to terminate an early pregnancy and often causes serious complications such as abnormal uterine bleeding and endometritis. Buxue Yimu granule (BYG) is a well-known traditional Chinese medicine prescription composed of five kinds of drugs and is widely used in gynecology and obstetrics. The aim of the present study was to establish the quality standard of BYG and investigate its protective effect on incomplete abortion. The chemical fingerprint of BYG was established by high performance liquid chromatography (HPLC). The major compounds of BYG were determined by ultra-performance liquid chromatography with triple quadrupole mass spectrometry. An incomplete abortion rat model was induced by intragastric administration of mifepristone (8.3 mg·kg−1) combined with misoprostol (100.0 μg·kg−1) during early pregnancy. The serum levels of human chorionic gonadotrophin (HCG), estradiol (E2), and progesterone (PG) were determined. The serum endogenous metabolites were analyzed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Multivariate analysis, including partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA), was employed to analyze the metabolic profiles, and MetaboAnalyst was used to investigate the metabolic pathways. Furthermore, hematoxylin-eosin staining (HE) was used to evaluate the histopathological changes in uterine tissue. The expression levels of VEGFA and NF-κB were detected by immunohistochemistry. The results indicated that HPLC fingerprint analysis can be successfully used to assess the quality of BYG. The medical-induced incomplete abortion rats were clearly separated from control rats, and the biochemical changes were gradually restored to normal after administration of BYG. Moreover, 19 potential biomarkers, including N-lactoylleucine, 2-piperidinone, isobutyryl-l-carnitine, eicosapentaenoylcholine, LysoPC(14:0), LysoPC(20:5), physagulin C, LysoPC(18:3), leukotriene D5, deoxycholic acid 3-glucuronide, glycine, pregnanediol 3-O-glucuronide, LysoPC(18:2), LysoPC(17:0/0:0), N-acetyl-leukotriene E4, LysoPC(18:0), platelet-activating factor, LysoPA(24:1), and LysoPC(18:1), which were mainly related to the amino acids metabolism, lipids metabolism, and bile acid biosynthesis, were identified. Consequently, BYG exerts a potential protective role in the intervention of incomplete abortion by anti-inflammatory, promote endometrial repair, and regulate the metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Chemical Fingerprint Analysis and Ultra-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Study of the Protective Effect of Buxue Yimu Granule in Medical-Induced Incomplete Abortion Rats

Zhang

Chen

et al. 2020

Front. Pharmacol.

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“…TCM has a long history in treating menstrual diseases and infertility related to PCOS and has achieved good effects 12 Evidence-Based Complementary and Alternative Medicine [56]. In this study, several network pharmacology-based methods were used to predict potential targets.…”

Section: Discussionmentioning

confidence: 99%

Identification of the Active Constituents and Significant Pathways of Cangfu Daotan Decoction for the Treatment of PCOS Based on Network Pharmacology

Tang

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Polycystic ovary syndrome (PCOS) is the most common female endocrine disease. Cangfu Daotan Decoction (CDD) can effectively relieve the clinical symptoms of PCOS patients. Methods. To explore the active ingredients and related pathways of CDD for treating PCOS, a network pharmacology-based analysis was carried out. The active ingredients of CDD and their potential targets were obtained from the TCM system pharmacology analysis platform. The obtained PCOS-related genes from OMIM and GeneCards were imported to establish protein-protein interaction networks in STRING. Finally, GO analysis and significant pathway analysis were conducted with the RStudio (Bioconductor) database. Results. A total of 111 active compounds were obtained from 1433 ingredients present in the CDD, related to 118 protein targets. In addition, 736 genes were found to be closely related to PCOS, of which 44 overlapped with CDD and were thus considered therapeutically relevant. Pathway enrichment analysis identified the AGE-RAGE signalling pathway in diabetic complications, endocrine resistance, the IL-17 signalling pathway, the prolactin signalling pathway, and the HIF-1 signalling pathway. Moreover, PI3K-Akt, insulin resistance, Toll-like receptor, MAPK, and AGE-RAGE were related to PCOS and treatment. Conclusions. CDD can effectively improve the symptoms of PCOS, and our network pharmacological analysis lays the foundation for future clinical research.

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“…45 Besides, PCOS patients were prescribed with the most popular JWXYS formula (38%) using an average daily dose of 6.1g. 46…”

Section: Jia-wei-xiao-yao-san Formula Indicationsmentioning

confidence: 99%

A network pharmacological approach to evaluate Jia-Wei-Xiao-Yao-san formula’s mechanistic pathways and its implication in the symptomatology of polycystic ovarian syndrome

Leclerc¹,

Wu²,

Wu³

2020

IJCAM

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Polycystic ovary syndrome (PCOS) is a disorder characterized mainly by a disruption of androgen secretion or endocrine feedback mechanism dysfunction occurring subtlety during adolescence and progressively impairing the ovarian folliculogenesis which affects preponderantly women of reproductively active age. Most of the reproductive active period of women is hampered by this condition, thereof reducing their fertility and causing metabolic disturbances. Traditional Chinese Medicine principles have been historically settled to develop Chinese Herbal Medicine formulas designed to treat various ailments including reproductive disorders. This study addresses the mechanisms of action of Jia-Wei-Xiao-Yao-San formula by examining the functional predicted PCOS-related targets networks first enriched by STITCH chemical interactions and then analyzed by STRING protein interactions database. Using the highest confidence interaction score as a screening binding parameter, we obtained a total of 274 PCOS-related targets interacting with 58 bioactive compounds from the formula and 22 PCOS-related drugs interacting with a total of 133 PCOS-related targets. Our analysis identified a total of 84 common PCOSrelated targets shared by both the formula and the PCOS-related drugs and demonstrate the predicted PCOS-related protein-protein interaction network resulting in various KEGG pathways. These findings indicated the formula functionality role preponderantly in cholesterol metabolism, ovarian steroidogenesis, peroxisome proliferator-activated receptors, and adipocytokine signaling pathway. Numerous compounds identified here are known to have high binding interactions with PCOS-related targets. Our methodological approach demonstrates that both the drugs-PCOS-related targets network support Jia-Wei-Xiao-Yao-San formula as an appropriate Traditional Chinese Medicine to treat at least the symptoms associated with PCOS manifestations.

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The prescription patterns of traditional Chinese medicine for women with polycystic ovary syndrome in Taiwan

Cited by 21 publications

References 22 publications

Chemical Fingerprint Analysis and Ultra-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Study of the Protective Effect of Buxue Yimu Granule in Medical-Induced Incomplete Abortion Rats

Chemical Fingerprint Analysis and Ultra-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Study of the Protective Effect of Buxue Yimu Granule in Medical-Induced Incomplete Abortion Rats

Identification of the Active Constituents and Significant Pathways of Cangfu Daotan Decoction for the Treatment of PCOS Based on Network Pharmacology

A network pharmacological approach to evaluate Jia-Wei-Xiao-Yao-san formula’s mechanistic pathways and its implication in the symptomatology of polycystic ovarian syndrome

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