This paper aims to settle the continuous prescribed-time stabilization problem of second-order nonlinear systems with mismatched disturbances. A continuous prescribed-time sliding mode control (CPTSMC) method with a prescribed-time extended state observer (PTESO) is proposed. The PTESO can precisely estimate the unknown states and disturbances, with its upper bound for the settling time (UBST) prescribed by only one parameter more tightly than existing finite-time or fixed-time ESOs. Furthermore, as a common concern for ESOs, the peaking value problem is well addressed. Then, a novel prescribed-time convergent form with little conservatism and simple tuning procedures is designed, and the internal mechanism in acquiring higher transient performance is explicitly researched. By using the estimated states and disturbances, the CPTSMC makes system states converge in a chattering-alleviated manner following the novel prescribed-time form. In addition to proving that the UBST of the whole system is tightly prescribed by only one design parameter, we show the continuity of the CPTSMC and the boundedness of all system signals, which are vital for practical applications. Ultimately, numerical simulations on the second-order system and a DC motor servo verify the efficiency of the proposed control system.