The prescribed duration algorithm: utilising ‘free text’ from multiple primary care electronic systems

Brooks, Caroline; Lyons, Ronan A.; Jones, Kerina; Hutton, Andrew J.; Walker, Roger; Evans, Karen A.; Lloyd, Kenneth E.; Ford, David

doi:10.1002/pds.2012

Cited by 2 publications

(2 citation statements)

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“…The study was based on hospital inpatient data, from the Patient Episode Database for Wales (PEDW), with systematic record linkage to death certificate data from the National Health Service (NHS) Welsh Administrative Register, as part of the Secure Anonymised Information Linkage (SAIL) databank [21]–[23]. As described previously [17], [21], [22], PEDW covers inpatient and day case admissions to all NHS hospitals across 22 local health authorities and has been used as the basis of many previous published studies [17], [23]–[29]. The systematic record linkage of inpatient and mortality data enables deaths following discharge from hospital to be identified and included with in-hospital deaths.…”

Section: Methodsmentioning

confidence: 99%

“…The second control comparison was made by applying age and sex specific mortality rates, additionally matched for social deprivation and the six major co-morbidities, from the general population of adult patients in primary care data across Wales throughout the eight year study period (total n = 3.75 million), to the study patients. The primary care data was obtained through the SAIL databank [21]–[23], and covers one third of all general practices across Wales during the study period.…”

Section: Methodsmentioning

confidence: 99%

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Prognosis following Upper Gastrointestinal Bleeding

2012

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BackgroundUpper gastrointestinal (GI) bleeding is one of the most common, high risk emergency disorders in the western world. Almost nothing has been reported on longer term prognosis following upper GI bleeding. The aim of this study was to establish mortality up to three years following hospital admission with upper GI bleeding and its relationship with aetiology, co-morbidities and socio-demographic factors.MethodsSystematic record linkage of hospital inpatient and mortality data for 14 212 people in Wales, UK, hospitalised with upper GI bleeding between 1999 and 2004 with three year follow-up to 2007. The main outcome measures were mortality rates, standardised mortality ratios (SMRs) and relative survival.ResultsMortality at three years was 36.7% overall, based on 5215 fatalities. It was highest for upper GI malignancy (95% died within three years) and varices (52%). Compared with the general population, mortality was increased 27-fold during the first month after admission. It fell to 4.3 by month four, but remained significantly elevated during every month throughout the three years following admission.The most important independent prognostic predictors of mortality at three years were older age (mortality increased 53 fold for people aged 85 years and over compared with those under 40 years); oesophageal and gastric/duodenal malignancy (48 and 32 respectively) and gastric varices aetiologies (2.8) when compared with other bleeds; non-upper GI malignancy, liver disease and renal failure co-morbidities (15, 7.9 and 3.9); social deprivation (29% increase for quintile V vs I); incident bleeds as an inpatient (31% vs admitted with bleeding) and male patients (25% vs female).ConclusionOur study shows a high late as well as early mortality for upper GI bleeding, with very poor longer term prognosis following bleeding due to malignancies and varices. Aetiologies with the worst prognosis were often associated with high levels of social deprivation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Prognosis following Upper Gastrointestinal Bleeding

2012

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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The prescribed duration algorithm: utilising ‘free text’ from multiple primary care electronic systems

Abstract: The algorithm proved to be applicable and efficient for assessing prescribed duration, with sensitivity and specificity values close to the manual review, but with the added advantage that the computer can process large volume of scripts rapidly and automatically.

Cited by 2 publications

References 6 publications

Prognosis following Upper Gastrointestinal Bleeding

Prognosis following Upper Gastrointestinal Bleeding

Current awareness: Pharmacoepidemiology and drug safety

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