The preproliferative stage in type 2 macular telangiectasia (MacTel type 2)

Venkatesh, Ramesh; Reddy, Nikitha Gurram; Mishra, Pranjal; Pereira, Arpitha; Mutalik, Deepashri; Agrawal, Sameeksha; Bhatt, Abhishek; Yadav, Naresh Kumar; Chhablani, Jay

doi:10.1007/s00417-021-05371-1

Cited by 4 publications

(5 citation statements)

References 25 publications

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“… 1 The characteristic FA findings include the visibility of late diffuse perifoveal hyperfluorescence in the absence of SRNVM and presence of diffuse and focal intense hyperfluorescence in the presence of SRNVM. 18 There is a small subset of eyes which do not show any biomicroscopic clinical features of type 2 MacTel. These eyes are usually fellow eyes of confirmed cases of type 2 MacTel.…”

Section: Discussionmentioning

confidence: 99%

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Is type 2 macular telangiectasia a bilateral and symmetrical disease entity?

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…16 OCTA images were analyzed where available to look for the features in type 2 MacTel. 17 18 All OCTA scans with signal strength index ≥60, with proper segmentation and with no artifacts were evaluated for the study.…”

Section: Ethodsmentioning

confidence: 99%

Is type 2 macular telangiectasia a bilateral and symmetrical disease entity?

et al. 2022

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“…Venkatesh et al proposed a preproliferative stage of MacTel that could help identify patients at risk of proliferative disease. 37 …”

Section: Introductionmentioning

confidence: 99%

“…This intense hyperfluorescence could be due to staining at the level of the outer retina or the development of intraretinal new vessels. 37 SNV usually develops near migrating intraretinal pigment epithelium, appears to originate from the deep retinal circulation, and is characterized by early and late fluorescein leakage. 52 …”

Section: Introductionmentioning

confidence: 99%

Macular Telangiectasia Type 2: A Comprehensive Review

Kedarisetti¹,

Narayanan²,

Stewart³

et al. 2022

OPTH

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Macular telangiectasia Type 2 (MacTel) is a gradually progressive disease that affects the quality of life by impairing both distant and near vision. It had previously been considered a vascular condition, but recent evidence suggests a neurodegenerative etiology, with primary involvement of Muller cells. Retinal pigment epithelium (RPE) hyperplasia and subretinal neovascularization (SNV) are responsible for most of the vision loss in advanced cases. Neurotrophic factors in the non-proliferative phase and intravitreal anti-Vascular Endothelial growth factor (VEGF) in the proliferative phase have shown to retard the progression of the disease. This review will discuss the pathophysiology, clinical features, important diagnostic imaging studies and available treatment options for MacTel.

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“…Idiopathic macular telangiectasia type 2 (IMT) is a vascular disease that presents with bilateral, idiopathic, and perifoveal retinal telangiectatic vessel formations. [ 1 ] Yannuzzi et al . [ 2 ] divided the IMT into two groups: type-1 IMT is characterized by cystic macular edema, retinal thickening, and exudations, whereas type-2 IMT is characterized by perifoveal telangiectasia.…”

mentioning

confidence: 99%

Proximal nailfold videocapillaroscopy findings of patients with idiopathic macular telangiectasia type 2

Gedik,

Erol,

Bulut

et al. 2023

Indian Journal of Ophthalmology

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Purpose: Idiopathic macular telangiectasia type 2 (IMT) is a neurodegenerative disease characterized by bilateral, idiopathic, and perifoveal retinal telangiectatic vessel formations. We aimed to compare proximal nailfold videocapillaroscopy (NV) findings between patients with IMT and healthy individuals and evaluate the optical coherence tomography angiography (OCTA) parameters of the patients with IMT according to their NV findings. Methods: The study included 43 patients with IMT and 92 healthy controls of similar age and gender without any additional diseases. The OCTA and NV findings of the patients and controls were examined. Results: The mean age was 59.76 ± 5.73 years in the IMT group and 58.23 ± 4.96 years in the control group. Of the 43 patients with IMT, 19 were found to have increased capillary tortuosity, six had microhemorrhage, and 18 had bizarre capillaries (P < 0.001). In the IMT group, the total vascular density value of the superficial capillary plexus was higher among the patients with capillary microhemorrhage (P = 0.001), and the subfoveal choroidal thickness was lower among those with increased capillary tortuosity and bizarre capillaries (P = 0.04 and P = 0.07, respectively). Conclusion: This is the first study in which the NV findings of patients with IMT were compared with those of a control group. We found higher rates of increased capillary tortuosity, microhemorrhage, and bizarre capillaries in the IMT group compared to the controls. We consider that this situation is caused by microvascular damage. We also think that IMT is a systemic disease that affects both proximal nailfold capillaries and eye vessels.

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The preproliferative stage in type 2 macular telangiectasia (MacTel type 2)

Cited by 4 publications

References 25 publications

Is type 2 macular telangiectasia a bilateral and symmetrical disease entity?

Is type 2 macular telangiectasia a bilateral and symmetrical disease entity?

Macular Telangiectasia Type 2: A Comprehensive Review

Proximal nailfold videocapillaroscopy findings of patients with idiopathic macular telangiectasia type 2

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