Synthetic approaches towards two CF3O-containing building blocks 2-(trifluoromethoxy)ethan-1-ol and 3-(trifluorometho-xy)propan-1-ol were developed. The most convenient approach included synthesis of the corresponding esters - ethyl 2-(trifluoro-methoxy)acetate and methyl 3-(trifluoromethoxy)propanoate. Obtained alochols are of interest for further application in drug discovery projects