The Preparation of Some Derivatives of β-(10-Phenothiazinyl)propionic Acid and β-(2-Chloro-10-phenothiazinyl)propionic Acid

Synthesis and Characterization of Phenothiazine Labeled Oligodeoxynucleotides: Novel 2‘-Deoxyadenosine and Thymidine Probes for Labeling DNA

“…The 3-phenothiazin-10-ylpropionic acid, 3, was prepared by first reacting PTZ with acrylonitrile in the presence of tetrabutylammonium hydroxide (87% yield), followed by hydrolysis with sodium hydroxide in aqueous methanol to afford the product in 56% yield (32). As shown in Scheme 2, the 5′-position of thymidine was converted from a hydroxyl to an amine in three consecutive steps.…”

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds

“…Starting acids 6-8 were obtained by Michael addition reaction of carbazole 12, phenothiazine 13 or 2-chlorophenothiazine 14 with acrylonitrile in the presence of Triton B, 16,17 followed by hydrolysis of nitrile 9-11 with aqueous sodium hydroxide in methanol. 16,17 The key intermediates, activated esters 3, 4, 2,13 5, were then prepared by reaction between carboxylic acids 6, 7 and 8 with N-hydroxysuccinimide in the presence of EDCI [1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride]. 18 Furthermore, coupling reactions of activated esters 3 and 4 with L-cysteinyl, methionyl, serinyl or valinyl esters provided the corresponding esters 2a-h (Scheme 1).…”

Chemistry and heterocyclization of carbohydrazides

“…Reaction between an isothiocyanates 44 and carbohydrazides 1 in benzene gave acylthiosemicarbazides 45 in yields ranging from 88 to 95% [47–52]. …”